De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis of current clinical trials

2014 ◽  
Vol 50 (15) ◽  
pp. 2636-2648 ◽  
Author(s):  
Liam Masterson ◽  
Daniel Moualed ◽  
Zi Wei Liu ◽  
James E.F. Howard ◽  
Raghav C. Dwivedi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Clinical Trials ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Treatment Protocols

Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis

2020 ◽  
Vol 156 ◽  
pp. 103116
Author(s):  
Bruno Augusto Linhares Almeida Mariz ◽  
Luiz Paulo Kowalski ◽  
William Nassib William ◽  
Gilberto de Castro ◽  
Aline Lauda Freitas Chaves ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Global Prevalence

Current status of human papillomavirus positivity in oropharyngeal squamous cell carcinoma in Europe: a systematic review

2019 ◽  
Vol 139 (12) ◽  
pp. 1112-1116 ◽  
Author(s):  
Karoline Dyrberg Stjernstrøm ◽  
Jakob Schmidt Jensen ◽  
Kathrine Kronberg Jakobsen ◽  
Christian Grønhøj ◽  
Christian von Buchwald
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Current Status

Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis

Oral Oncology ◽  
2016 ◽  
Vol 54 ◽  
pp. 15-27 ◽  
Author(s):  
Parish P. Sedghizadeh ◽  
William D. Billington ◽  
Dain Paxton ◽  
Rabeh Ebeed ◽  
Susan Mahabady ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Favorable Prognosis

Survival-related epithelial-mesenchymal transition proteins in oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis

2021 ◽  
pp. 105267
Author(s):  
Glória Maria de França ◽  
Ana Claudia de Macedo Andrade ◽  
Fernanda Aragão Felix ◽  
Weslay Rodrigues da Silva ◽  
Dennys Ramon de Melo Fernandes Almeida ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Meta Analysis ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Mesenchymal Transition

scholarly journals Human Papillomavirus and Survival of Sinonasal Squamous Cell Carcinoma Patients: A Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3677
Author(s):  
Anish Sharma ◽  
Alice L. Tang ◽  
Vinita Takiar ◽  
Trisha M. Wise-Draper ◽  
Scott M. Langevin
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Statistical Power ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Hpv Status ◽  
The Impact

Human papillomavirus (HPV) is detectable in a subset of sinonasal squamous cell carcinoma (SNSCC), but the impact on patient outcomes is presently unclear due to a modest number of studies with limited statistical power. Therefore, we conducted a systematic review and meta-analysis to better clarify this relationship. A PubMed search was conducted to identify all studies reporting on overall (OS) or disease-free survival (DFS) for SNSCC by HPV status. Hazard ratios (HR) and corresponding 95% confidence intervals (CI) were extracted or, when not provided, indirectly estimated from each manuscript. Summary survival curves for 5-year OS and estimating survival probability by HPV status at pre-specified time intervals from study-specific Kaplan-Meier curves generated 2-year DFS. Log HRs and log CIs were combined across studies to generate summary estimates and a corresponding 95% CIs for OS and DFS. We identified ten unique studies reporting on OS and four for DFS. We observed a significant association between HPV and OS (summary HR = 0.51, 95% CI: 0.38–0.70) with relatively low heterogeneity between studies. These results indicate that HPV is a significant predictor of more favorable survival for SNSCC, and thus may be a useful biomarker for prognostication and, potentially, treatment modulation.

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