scholarly journals Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study

2013 ◽  
Vol 49 (12) ◽  
pp. 2621-2632 ◽  
Author(s):  
Mario Campone ◽  
Thomas Bachelot ◽  
Michael Gnant ◽  
Ines Deleu ◽  
Hope S. Rugo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Postmenopausal Women ◽  
Subgroup Analysis ◽  
Advanced Breast ◽  
Efficacy And Safety ◽  
Breast Cancer Subgroup ◽  
Visceral Metastases

scholarly journals 10 years of success achieved by eribulin while treating HER2-negative mBC: from randomized studies to routine practice

2021 ◽  
Vol 17 (3) ◽  
pp. 59-68
Author(s):  
I. V. Kolyadina
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Brain Lesion ◽  
Advanced Breast ◽  
Routine Practice ◽  
Clinical Settings ◽  
Efficacy And Safety ◽  
Randomized Studies ◽  
Visceral Metastases

The article reviews studies evaluating the efficacy and safety of eribulin chemotherapy in patients with HER2-negative advanced breast cancer. It analyzes the results derived from large randomized studies, highlights the main advantages peculiar to eribulin, and describes the key mechanisms of the antitumor activity displayed by the drug. Among those presented, there are significant retrospective studies evaluating the role of eribulin chemotherapy in late and early advanced breast cancer treatment lines, as well as an analysis of surveys aimed to evaluate the efficacy of the drug in various clinical settings (for visceral metastases, brain lesion, and in elderly patients). This article reflects the main results of Russian population analyses evaluating the efficacy and safety of eribulin chemotherapy in routine clinical practice.

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