Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression

2013 ◽  
Vol 49 (7) ◽  
pp. 1715-1724 ◽  
Author(s):  
Toshiki Oguro ◽  
Kei Ishibashi ◽  
Takashi Sugino ◽  
Koichi Hashimoto ◽  
Shintaro Tomita ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Renal Cell Carcinoma Cell ◽  
Socs3 Expression

scholarly journals Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172555 ◽  
Author(s):  
Xiao-dong Pan ◽  
Dong-hua Gu ◽  
Jia-Hui Mao ◽  
Hua Zhu ◽  
Xinfeng Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Renal Cell Carcinoma Cell

scholarly journals PI3K-Akt-mTOR inhibition by GNE-477 inhibits renal cell carcinoma cell growth in vitro and in vivo

Aging ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 9489-9499
Author(s):  
Xueting Ye ◽  
Jian-Wei Ruan ◽  
Hang Huang ◽  
Wei-Ping Huang ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Mtor Inhibition ◽  
Renal Cell Carcinoma Cell

scholarly journals Bromodomain-Containing Protein 4 (BRD4) Inhibition Sensitizes Palomid 529-Induced Anti-Renal Cell Carcinoma Cell Activity in Vitro and in Vivo

2018 ◽  
Vol 50 (2) ◽  
pp. 640-653 ◽  
Author(s):  
Zhao-yu Xing ◽  
Yin Wang ◽  
Long Cheng ◽  
Jie Chen ◽  
Xiao-zhou He ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Cell Apoptosis ◽  
Renal Cell ◽  
Elisa Assay ◽  
Dual Inhibitor ◽  
Brd4 Inhibition

Background/Aims: Mammalian target of rapamycin (mTOR) is a valuable treatment target of renal cell carcinoma (RCC). Palomid 529 is a novel mTORC1/2 dual inhibitor. Methods: RCC cells were treated with different concentrations of Palomid 529. Cell survival was tested by MTT assay and clonogenicity assay. Cell proliferation was tested by BrdU ELISA assay. Cell apoptosis was tested by the Hoechst-33342 nuclei staining assay and Histone DNA ELISA assay. mTOR signaling was tested by Western blotting assay and co-immunoprecipitation (IP) assay. The SCID mouse 786-O xenograft model was established to test RCC cell growth in vivo. Results: Palomid 529 exerted cytotoxic, anti-proliferative and pro-apoptotic activities in 786-O RCC cells. Palomid 529 disassembled mTORC1/2, causing de-phosphorylation of mTORC1/2 substrates. Bromodomain-containing protein 4 (BRD4) is a primary resistant factor of Palomid 529. Palomid 529-induced 786-O cell apoptosis was sensitized by BRD4 inhibitors or BRD4 silencing, but inhibited with BRD4 over-expression. Palomid 529-induced cytotoxicity in the primary human RCC cells was negatively correlated with BRD4 expression level. In vivo, Palomid 529 i.p. administration inhibited 786-O xenograft tumor growth in SCID mice. Its anti-tumor activity was further sensitized by co-administration of the BRD4 inhibitor JQ1. Cconclusion: Palomid 529 inhibits RCC cell growth in vitro and in vivo. BRD4 inhibition could further sensitize Palomid 529 against RCC cells.

scholarly journals MP72-13 EFFECT OF A KETOGENIC DIET ON THE CLEAR CELL RENAL CELL CARCINOMA CELL GROWTH

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Maxime Benoit ◽  
Edouard Fortier ◽  
Magalie Barth ◽  
Vincent Procaccio ◽  
Jennifer Bourreau ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Ketogenic Diet ◽  
Renal Cell ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Cell Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell

Effect of a ketogenic diet on the clear cell renal cell carcinoma cell growth

2018 ◽  
Vol 17 (2) ◽  
pp. e57-e59
Author(s):  
M. Benoit ◽  
E. Fortier ◽  
M. Barth ◽  
V. Procaccio ◽  
J. Bourreau ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Ketogenic Diet ◽  
Renal Cell ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Cell Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell

Characterization of a Renal Cell Carcinoma Cell Line Suitable as a Target for Immunological Studies in Vitro and in the NU/NU Mouse

1985 ◽  
Vol 134 (6) ◽  
pp. 1271-1275 ◽  
Author(s):  
Martin H. Goldrosen ◽  
Robert Huben ◽  
Glenn A. Miller ◽  
David A. Lewis ◽  
Hisako Ochi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Renal Cell Carcinoma Cell
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