New insights of mitochondria reactive oxygen species generation and cell apoptosis induced by low dose photodynamic therapy

2011 ◽  
Vol 47 (18) ◽  
pp. 2750-2761 ◽  
Author(s):  
Hongyou Zhao ◽  
Da Xing ◽  
Qun Chen
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cell Apoptosis ◽  
Low Dose ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species

Cascade of reactive oxygen species generation by polyprodrug for combinational photodynamic therapy

Biomaterials ◽  
2020 ◽  
Vol 255 ◽  
pp. 120210 ◽  
Author(s):  
Zujian Feng ◽  
Jinxuan Guo ◽  
Xiang Liu ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals PHOTODYNAMIC THERAPY: NEW LIGHT IN MEDICINE WORLD

2010 ◽  
Vol 8 (2) ◽  
pp. 279-291 ◽  
Author(s):  
Venny Santosa ◽  
Leenawaty Limantara
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Type I ◽  
Oxygen Species ◽  
Type Ii ◽  
Light Spectrum ◽  
Medical Field

Photodynamic therapy (PDT) is a considerably new kind of photochemotherapeutic treatment in medical field. It combines the use of three components, which are a photosensitizer, light and oxygen. Photosensitizer is a compound activated by light. The application can be oral, topical or intravenous. It usually member of porphyrin group with ampiphilic characteristics. Photosensitizer can be of generation I, II or III, each generation step develops more specificity, selectivity and deeper tissue application. This review will discuss photosensitizer development consecutively, with its benefit and lackness. The light used is usually on red region, while the oxygen is involved in reactive oxygen species generation. Its mechanism action can go through either in type I or type II reaction. This kind of therapy is usually being used in oncology, especially in superficial and in-lining cancers, dermatology and ophthalmology field. This therapy can be safely given to patients with complication and has distinct advantages compare with other treatment such as chemotherapy and surgery. It also considerably has lesser side effects and risks. Broader application is being developed through various experiments and photosensitizer modification.   Keywords: light spectrum, photoactivation, photodynamic therapy, photosensitizer

scholarly journals Binary organic nanoparticles with enhanced reactive oxygen species generation capability for photodynamic therapy

2021 ◽  
pp. 2150009
Author(s):  
Xiaofu Weng ◽  
Zhouzhou Bao ◽  
Xunbin Wei
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Enhanced Fluorescence ◽  
New Strategy ◽  
Biological Environment

Photodynamic therapy (PDT) takes advantage of photosensitizers (PSs) to generate reactive oxygen species (ROS) for cell killing when excited by light. It has been widely used in clinic for therapy of multiple cancers. Currently, all the FDA-approved PSs, including porphyrin, are all small organic molecules, suffering from aggregation-caused quenching (ACQ) issues in biological environment and lacking tumor targeting capability. Nanoparticles (NPs) with size between 20[Formula: see text]nm and 200[Formula: see text]nm possess tumor targeting capability due to the enhanced permeability and retention (EPR) effect. It is urgent to develop a new strategy to form clinical-approved-PSs-based NPs with improved ROS generation capability. In this study, we report a strategy to overwhelm the ACQ of porphyrin by doping it with a type of aggregation-induced emission (AIE) luminogen to produce a binary NPs with high biocompatibility, and enhanced fluorescence and ROS generation capability. Such NPs can be readily synthesized by mixing a porphyrin derivative, Ce6 with a typical AIE luminogen, TPE-Br. Here, our experimental results have demonstrated the feasibility and effectiveness of this strategy, endowing it a great potential in clinical applications.

scholarly journals Catha edulis extract induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of mitochondrial proteins

2016 ◽  
Vol 12 (46) ◽  
pp. 321 ◽  
Author(s):  
Syam Mohan ◽  
SiddigIbrahim Abdelwahab ◽  
YahyaHasan Hobani ◽  
Suvitha Syam ◽  
AdelS Al-Zubairi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Apoptosis ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Mitochondrial Proteins ◽  
H9c2 Cell ◽  
Oxygen Species ◽  
Catha Edulis

scholarly journals Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress

2020 ◽  
Vol 11 (13) ◽  
pp. 3405-3417 ◽  
Author(s):  
Zeyan Zhuang ◽  
Jun Dai ◽  
Maoxing Yu ◽  
Jianqing Li ◽  
Pingchuan Shen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endoplasmic Reticulum ◽  
Photodynamic Therapy ◽  
Endoplasmic Reticulum Stress ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Type I ◽  
Oxygen Species

Phosphindole oxide-based photosensitizers with Type I reactive oxygen species generation ability are developed and used for endoplasmic reticulum stress-mediated photodynamic therapy of tumors.

Sign in / Sign up

Export Citation Format

Share Document