scholarly journals Determining circulating endothelial cells using CellSearch system during preoperative systemic chemotherapy in breast cancer patients

2011 ◽  
Vol 47 (15) ◽  
pp. 2265-2272 ◽  
Author(s):  
Arwa M. Ali ◽  
Takayuki Ueno ◽  
Sunao Tanaka ◽  
Masahiro Takada ◽  
Hiroshi Ishiguro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Patients ◽  
Systemic Chemotherapy ◽  
Circulating Endothelial Cells ◽  
Breast Cancer Patients ◽  
Cellsearch System

Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

Blood ◽  
2001 ◽  
Vol 97 (11) ◽  
pp. 3658-3661 ◽  
Author(s):  
Patrizia Mancuso ◽  
Alessandra Burlini ◽  
Giancarlo Pruneri ◽  
Aron Goldhirsch ◽  
Giovanni Martinelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Patients ◽  
Circulating Endothelial Cells ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Color Flow ◽  
Cell Adhesion Molecule 1 ◽  
Endothelial Growth Factor

Circulating endothelial cells (CECs) were enumerated in 20 healthy controls and 76 newly diagnosed cancer patients by means of 4-color flow cytometry. In breast cancer (n = 46) and lymphoma (n = 30) patients, both resting and activated CECs were increased by 5-fold (P < .0008 vs control). CECs significantly correlated with plasma levels of vascular cell adhesion molecule-1 and vascular endothelial growth factor. Resting and activated CECs were similar to healthy controls in 7 lymphoma patients achieving complete remission after chemotherapy, and activated CECs were found to decrease in 13 breast cancer patients evaluated before and 24 hours after quadrantectomy.

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