DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer

2011 ◽  
Vol 47 (12) ◽  
pp. 1817-1825 ◽  
Author(s):  
Kathrin Mutze ◽  
Rupert Langer ◽  
Felix Schumacher ◽  
Karen Becker ◽  
Katja Ott ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Dna Methyltransferase ◽  
Predictive Biomarker ◽  
Dna Methyltransferase 1 ◽  
Potential Therapeutic Target ◽  
Methyltransferase 1

MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer

2011 ◽  
Vol 29 (4) ◽  
pp. 2701-2709 ◽  
Author(s):  
Akao Zhu ◽  
Jiazeng Xia ◽  
Junbo Zuo ◽  
Shimao Jin ◽  
Hong Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Methyltransferase 1

scholarly journals Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zhifang Jia ◽  
Xing Wu ◽  
Donghui Cao ◽  
Chuan Wang ◽  
Lili You ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Dna Methyltransferase ◽  
Cox Regression ◽  
Methylation Status ◽  
Dna Methyltransferase 1 ◽  
Cox Regression Analysis ◽  
Independent Prognostic Marker ◽  
Gastric Cancer Patients ◽  
Methyltransferase 1

DNA methyltransferase 1 (DNMT1) plays a pivotal role in maintaining DNA methylation status. Polymorphisms ofDNMT1may modify the role of DNMT1 in prognosis of gastric cancer (GC). Our aim was to test whether polymorphisms ofDNMT1gene were associated with overall survival of GC. Four hundred and forty-seven GC patients who underwent radical tumorectomy were enrolled in the study. Five tagging SNPs (rs10420321, rs16999593, rs2228612, rs2228611, and rs2288349) of theDNMT1gene were genotyped by TaqMan assays. Kaplan-Meier survival plots and Cox proportional hazard regression were used to analyze the associations between SNPs ofDNMT1and survival of GC. Patients carrying rs2228611 GA/AA genotype tended to live longer than those bearing the GG genotype (HR 0.68, 95% CI: 0.51–0.91,P=0.007). Further multivariate Cox regression analysis showed that rs2228611 was an independent prognostic factor (GA/AA versus GG: OR 0.67, 95% CI 0.49–0.91,P=0.010). Nevertheless, other SNPs did not show any significant associations with survival of GC. Polymorphisms of theDNMT1gene may affect overall survival of GC. The SNP rs2228611 has the potentiality to serve as an independent prognostic marker for GC patients.

MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1

2014 ◽  
Vol 31 (3) ◽  
Author(s):  
Jiang Yan ◽  
Xiaoqiang Guo ◽  
Jiazeng Xia ◽  
Tin Shan ◽  
Chen Gu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Methyltransferase 1
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