Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer

2011 ◽  
Vol 47 (10) ◽  
pp. 1578-1584 ◽  
Author(s):  
Laszlo Otvos ◽  
Ilona Kovalszky ◽  
Mirko Riolfi ◽  
Rita Ferla ◽  
Julia Olah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Receptor Antagonist ◽  
Triple Negative Breast Cancer ◽  
Leptin Receptor ◽  
Triple Negative

scholarly journals Tobacco mosaic virus delivery of mitoxantrone for cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (34) ◽  
pp. 16307-16313 ◽  
Author(s):  
Richard D. Lin ◽  
Nicole F. Steinmetz
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Mouse Model ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Triple Negative Breast Cancer ◽  
Topoisomerase Ii ◽  
Triple Negative ◽  
Topoisomerase Ii Inhibitor ◽  
Virus Delivery

Tobacco mosaic virus-nanoparticle encapsulation of the topoisomerase II inhibitor mitoxantrone enables therapy in a mouse model of triple negative breast cancer.

scholarly journals Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 259
Author(s):  
Madhuchhanda Kundu ◽  
Sumita Raha ◽  
Avik Roy ◽  
Kalipada Pahan
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Transforming Growth Factor ◽  
Healthy Controls ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Patient Derived Xenograft

Although some therapies are available for regular breast cancers, there are very few options for triple-negative breast cancer (TNBC). Here, we demonstrated that serum level of IL-12p40 monomer (p40) was much higher in breast cancer patients than healthy controls. On the other hand, levels of IL-12, IL-23 and p40 homodimer (p402) were lower in serum of breast cancer patients as compared to healthy controls. Similarly, human TNBC cells produced greater level of p40 than p402. The level of p40 was also larger than p402 in serum of a patient-derived xenograft (PDX) mouse model. Accordingly, neutralization of p40 by p40 mAb induced death of human TNBC cells and tumor shrinkage in PDX mice. While investigating the mechanism, we found that neutralization of p40 led to upregulation of human CD4+IFNγ+ and CD8+IFNγ+ T cell populations, thereby increasing the level of human IFNγ and decreasing the level of human IL-10 in PDX mice. Finally, we demonstrated the infiltration of human cytotoxic T cells, switching of tumor-associated macrophage M2 (TAM2) to TAM1 and suppression of transforming growth factor β (TGFβ) in tumor tissues of p40 mAb-treated PDX mice. Our studies identify a possible new immunotherapy for TNBC in which p40 mAb inhibits tumor growth in PDX mice.

Abstract 20: Fluvastatin inhibits the development of breast cancer in SV40C3Tag mouse model of triple negative breast cancer

2020 ◽  
Author(s):  
Anjana Bhardwaj ◽  
Matthew D. Embury ◽  
Raniv D. Rojo ◽  
Constance Albarracin ◽  
Isabelle Bedrosian
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Triple Negative Breast Cancer ◽  
Triple Negative
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