Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: Quantitative immunohistochemistry in tissue microarrays

2011 ◽  
Vol 47 (5) ◽  
pp. 792-801 ◽  
Author(s):  
Sophie Giusiano ◽  
Claude Cochet ◽  
Odile Filhol ◽  
Eve Duchemin-Pelletier ◽  
Véronique Secq ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tissue Microarrays ◽  
Breast Carcinomas ◽  
Over Expression ◽  
Quantitative Immunohistochemistry ◽  
Metastatic Risk

scholarly journals c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays

2007 ◽  
Vol 96 (2) ◽  
pp. 329-335 ◽  
Author(s):  
S Garcia ◽  
J-P Dalès ◽  
J Jacquemier ◽  
E Charafe-Jauffret ◽  
D Birnbaum ◽  
...  
Keyword(s):  
Tissue Microarrays ◽  
Breast Carcinomas ◽  
Automated Quantification

Abstract 3063: Over expression of protein kinase Nek1 and its modulation by Thioridazine in prostate cancer

2019 ◽  
Author(s):  
Vibha Singh ◽  
Praveen K. Jaiswal ◽  
Hari K. Koul ◽  
Xiuping Yu ◽  
Arrigo Benedetti
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Over Expression

scholarly journals Over-expression of a protein kinase gene enhances the defense of tobacco against Rhizoctonia solani

Gene ◽  
2010 ◽  
Vol 452 (2) ◽  
pp. 54-62 ◽  
Author(s):  
Osmany Chacón ◽  
Marleny González ◽  
Yunior López ◽  
Roxana Portieles ◽  
Merardo Pujol ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Rhizoctonia Solani ◽  
Kinase Gene ◽  
Over Expression ◽  
Protein Kinase Gene

scholarly journals Negation of the cancer-preventive actions of selenium by over-expression of protein kinase C  and selenoprotein thioredoxin reductase

2009 ◽  
Vol 30 (9) ◽  
pp. 1553-1561 ◽  
Author(s):  
U. Gundimeda ◽  
J. E. Schiffman ◽  
S. N. Gottlieb ◽  
B. I. Roth ◽  
R. Gopalakrishna
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Thioredoxin Reductase ◽  
Over Expression ◽  
Kinase C ◽  
Preventive Actions

scholarly journals Over-expression of a single Ca2+-dependent protein kinase confers both cold and salt/drought tolerance on rice plants

2000 ◽  
Vol 23 (3) ◽  
pp. 319-327 ◽  
Author(s):  
Yusuke Saijo ◽  
Shingo Hata ◽  
Junko Kyozuka ◽  
Ko Shimamoto ◽  
Katsura Izui
Keyword(s):  
Protein Kinase ◽  
Drought Tolerance ◽  
Dependent Protein Kinase ◽  
Over Expression ◽  
Rice Plants ◽  
Dependent Protein

scholarly journals Recent Advances in Protein Kinase Activity Analysis Based on Nanomaterials

2019 ◽  
Vol 20 (6) ◽  
pp. 1440 ◽  
Author(s):  
Zhiyong Yan ◽  
Pingye Deng ◽  
Yang Liu
Keyword(s):  
Protein Kinase ◽  
Protein Kinases ◽  
Protein Kinase Activity ◽  
Signal Transducer ◽  
Post Translational Modifications ◽  
Over Expression ◽  
Surface Areas ◽  
Sensing Platforms ◽  
Proliferation And Apoptosis ◽  
Biochemical Research

Protein phosphorylation regulated by protein kinases, as well as their dephosphorylation, is one of the most common post-translational modifications, and plays important roles in physiological activities, such as intracellular signal communications, gene transcription, cell proliferation and apoptosis. Over-expression of protein kinases is closely associated with various diseases. Consequently, accurate detection of protein kinases activities and their relevant inhibitors screening is critically important, not only to the biochemical research, but also to the clinical diagnosis and therapy. Nanomaterials, taking advantage of large surface areas, as well as excellent electrical, catalytic, magnetic and optical properties, have been utilized as target concentrators, recognition components, signal transducer or amplification elements in protein kinase related assays. This review summarizes the recent representative works to highlight the applications of nanomaterials in different biosensor technologies for protein kinases activities detection and their inhibitors screening. First, different nanomaterials developed for phosphoprotein/phosphopeptide enrichment and phosphate recognition are introduced. Next, representative works are selected that mainly focus on the utilization of nanomaterials as signal transducer or amplification elements in various protein kinases sensing platforms, such as electrochemical, colorimetric, fluorescent, and mass spectroscopy-based approaches. Finally, the major challenges and perspectives of nanomaterials being applied in protein kinases related assays are discussed.

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