Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

2010 ◽  
Vol 46 (12) ◽  
pp. 2206-2215 ◽  
Author(s):  
Patrick Schöffski ◽  
Jean-Yves Blay ◽  
Jacques De Greve ◽  
Etienne Brain ◽  
Jean-Pascal Machiels ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Head And Neck Cancer ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Phase Ii Trial ◽  
Advanced Head ◽  
European Organization ◽  
Cancer Breast ◽  
Bi 2536

scholarly journals Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2)

2018 ◽  
Vol 49 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Takashi Matsuzuka ◽  
Naomi Kiyota ◽  
Junki Mizusawa ◽  
Tetsuo Akimoto ◽  
Masato Fujii ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Trial ◽  
Locally Advanced ◽  
Clinical Impact ◽  
Advanced Head

scholarly journals Qualidade de Vida Relacionada à Saúde de Pacientes com Câncer de Mama: Revisão Integrativa da Literatura

2020 ◽  
Vol 66 (1) ◽  
Author(s):  
Monique Binotto ◽  
Gilberto Schwartsmann
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cáncer De Mama ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Breast ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Introdução: O câncer de mama pode alterar a qualidade de vida relacionada à saúde das pacientes. Objetivo: Compreender o impacto da quimioterapia para câncer de mama na qualidade de vida relacionada à saúde de pacientes. Método: Trata-se de uma revisão integrativa da literatura, compreendendo artigos publicados entre 2007 e 2019, disponíveis nas bases de dados PubMed, LILACS e SciELO. Analisaram-se 25 artigos na íntegra. Resultados: Os questionários mais frequentemente utilizados nos estudos foram o European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) e o módulo complementar European Organization for Research and Treatment of Cancer Breast Cancer-specific Quality of Life Questionnaire (EORTC QLQ-BR23). Em relação às alterações da qualidade de vida, a saúde global diminui durante a quimioterapia, mas pode melhorar após o término do tratamento. O aumento dos sintomas é relatado em diversos estudos e prejudicou a qualidade de vida relacionada à saúde das pacientes. Entretanto, os sintomas diminuem após o término da quimioterapia, exceto para algumas escalas. As escalas de imagem corporal, função sexual e funcionamento físico pioram ao longo do tratamento. A qualidade de vida mental/psicológica tem oscilações durante o tratamento, assim como a escala sobre as relações sociais. Conclusão: A qualidade de vida relacionada à saúde de mulheres com câncer de mama é afetada negativamente pelo tratamento quimioterápico, expressando maior impacto nas escalas de sintomas.

Identification of factors associated with high breast cancer risk in the mothers of children with soft tissue sarcoma.

1990 ◽  
Vol 8 (4) ◽  
pp. 583-590 ◽  
Author(s):  
J M Birch ◽  
A L Hartley ◽  
V Blair ◽  
A M Kelsey ◽  
M Harris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Soft Tissue ◽  
Breast Cancer Risk ◽  
Soft Tissue Sarcoma ◽  
Cancer Risk ◽  
Cancer Genetics ◽  
Age At First Birth ◽  
Index Child ◽  
High Breast Cancer Risk ◽  
Age At Birth

Information on the past medical history of the mothers of a population-based series of 177 children with soft tissue sarcoma was obtained by interview and from medical records. Eight mothers developed breast cancer, six premenopausally, compared with 3.26 expected (P = .04), but no excess of other types of cancers was detected. High breast cancer risk was associated with the following factors in the index child: age at diagnosis less than 24 months (relative risk [RR], 7.84), embryonal rhabdomyosarcoma (RR, 3.74), and male sex (RR, 3.02). Characteristics in the mother associated with high breast cancer risk were the following: late age at first birth (RR, 5.13), late age at birth of index child (RR, 5.69), and high birth-rank order of index child (RR, 4.08). The results suggest there may be a subset of childhood soft tissue sarcoma with a predominantly genetic etiology. The association between premenopausal breast cancer in the mother, late age at birth of index child, and early onset of soft tissue sarcoma in the index child suggests that these three events are not independent and that interactions between genetic and other factors may be important. The identification of a group of women at high risk for breast cancer affords an opportunity for screening and early detection. The study of cancer family syndromes may provide insights into underlying mechanisms in cancer genetics.

Phase II Trial of Hyperfractionated Accelerated Split-Course Radiochemotherapy with 5-FU and Cis-DDP in Advanced Head and Neck Cancer

2004 ◽  
Vol 180 (12) ◽  
pp. 805-810 ◽  
Author(s):  
Antje Ernst-Stecken ◽  
Gerhard Grabenbauer ◽  
Heinrich Iro ◽  
Ludwig Plasswilm ◽  
Rolf Sauer
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Trial ◽  
Advanced Head
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