scholarly journals Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells

2010 ◽  
Vol 46 (5) ◽  
pp. 954-965 ◽  
Author(s):  
Yuji Basaki ◽  
Ken-ichi Taguchi ◽  
Hiroto Izumi ◽  
Yuichi Murakami ◽  
Takuya Kubo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Cell Cycle Progression ◽  
Human Cancer ◽  
Binding Protein ◽  
Cycle Progression ◽  
Human Cancer Cells ◽  
Dependent Pathway

scholarly journals CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1

2013 ◽  
Vol 73 (22) ◽  
pp. 6667-6678 ◽  
Author(s):  
Jae-Sung Kim ◽  
Eun Ju Kim ◽  
Jeong Su Oh ◽  
In-Chul Park ◽  
Sang-Gu Hwang
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Cell Cycle Progression ◽  
Human Cancer ◽  
Cycle Progression ◽  
Human Cancer Cells ◽  
The Stability

scholarly journals DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells

2012 ◽  
Vol 122 (3) ◽  
pp. 859-872 ◽  
Author(s):  
Naoe Taira ◽  
Rei Mimoto ◽  
Morito Kurata ◽  
Tomoko Yamaguchi ◽  
Masanobu Kitagawa ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Cell Cycle Progression ◽  
Human Cancer ◽  
Cycle Progression ◽  
Human Cancer Cells

scholarly journals Oncogenic role of ALX3 in cervical cancer cells through KDM2B-mediated histone demethylation of CDC25A

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jinhong Qi ◽  
Li Zhou ◽  
Dongqing Li ◽  
Jingyuan Yang ◽  
He Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Cycle Progression ◽  
Cervical Squamous Cell Carcinoma ◽  
Cycle Progression ◽  
Normal Tissues ◽  
Positive Regulator ◽  
Cervical Cancer Cells

Abstract Background Cell division cycle 25A (CDC25A) is a well-recognized regulator of cell cycle progression and is involved in cancer development. This work focused on the function of CDC25A in cervical cancer cell growth and the molecules involved. Methods A GEO dataset GSE63514 comprising data of cervical squamous cell carcinoma (CSCC) tissues was used to screen the aberrantly expressed genes in cervical cancer. The CDC25A expression in cancer and normal tissues was predicted in the GEPIA database and that in CSCC and normal cells was determined by RT-qPCR and western blot assays. Downregulation of CDC25A was introduced in CSCC cells to explore its function in cell growth and the cell cycle progression. The potential regulators of CDC25A activity and the possible involved signaling were explored. Results CDC25A was predicted to be overexpressed in CSCC, and high expression of CDC25A was observed in CSCC cells. Downregulation of CDC25A in ME180 and C33A cells reduced cell proliferation and blocked cell cycle progression, and it increased cell apoptosis. ALX3 was a positive regulator of CDC25A through transcription promotion. It recruited a histone demethylase, lysine demethylase 2B (KDM2B), to the CDC25A promoter, which enhanced CDC25A expression through demethylation of H3k4me3. Overexpression of ALX3 in cells blocked the inhibitory effects of CDC25A silencing. CDC25A was found as a positive regulator of the PI3K/Akt signaling pathway. Conclusion This study suggested that the ALX3 increased CDC25A expression through KDM2B-mediated demethylation of H3K4me3, which induced proliferation and cell cycle progression of cervical cancer cells.

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