Health related quality of life in the first year after diagnosis in children with brain tumours compared with matched healthy controls; a prospective longitudinal study

2008 ◽  
Vol 44 (9) ◽  
pp. 1243-1252 ◽  
Author(s):  
Anthony Penn ◽  
Stephen P. Lowis ◽  
Linda P. Hunt ◽  
Robert I. Shortman ◽  
Michael C.G. Stevens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumours ◽  
First Year ◽  
Healthy Controls ◽  
Health Related Quality ◽  
Prospective Longitudinal Study ◽  
Related Quality ◽  
Health Related ◽  
Prospective Longitudinal

scholarly journals Voice Quality, Function, and Quality of Life for Laryngeal Cancer: A Prospective Longitudinal Study Up to 24 Months Following Radiotherapy

2020 ◽  
pp. 014556132092994
Author(s):  
Lisa Tuomi ◽  
Therese Karlsson
Keyword(s):  
Quality Of Life ◽  
Laryngeal Cancer ◽  
Normal Population ◽  
Voice Quality ◽  
Healthy Controls ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Prospective Longitudinal

Objective: To study the potential changes of health-related quality of life (HRQL), voice quality, and communicative function up to 24 months following radiotherapy for patients with laryngeal cancer. Methods: A total of 28 patients with laryngeal cancer, treated by curatively intended radiotherapy were included in this prospective longitudinal descriptive study. Patients were followed pre-radiotherapy, 12 months, and 24 months post-radiotherapy. At each time point, voice recordings and patient-reported outcome instruments (European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core30, Head and Neck35, Swedish Self-Evaluation of Communication Experiences after Laryngeal Cancer) were completed. Perceptual analysis using the Grade-Roughness-Breathiness-Asthenia-Strain was performed using the voice recordings. Results: Voice quality remains inferior to the voices of healthy controls both before and up to 24 months post-radiotherapy, demonstrating no statistically significant changes during the study period. Self-perceived communicative function revealed a trend toward improvement. Health-related quality of life remains mostly at stable levels, however, with statistically significant deterioration regarding dry mouth and sticky saliva. Generally, patients reported inferior scores compared to a normal population. Conclusion: This study demonstrated no statistically significant changes over time in HRQL and perceptual voice quality at pre-radiotherapy compared to 24 months post-radiotherapy. However, the values remain inferior to the voices of healthy controls or a normal population.

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