Prognostic significance of oestrogen receptor alpha (ERα) and beta (ERβ), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas

2007 ◽  
Vol 43 (16) ◽  
pp. 2434-2444 ◽  
Author(s):  
Naim Shabani ◽  
Christina Kuhn ◽  
Susanne Kunze ◽  
Sandra Schulze ◽  
Doris Mayr ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
Prognostic Significance ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Endometrial Carcinomas

Oestrogen and progesterone receptor binding capacity and oestrogen receptor alpha expression (ERα mRNA) along the cervix of cycling ewes

2008 ◽  
Vol 20 (3) ◽  
pp. 350 ◽  
Author(s):  
M. Rodríguez-Piñón ◽  
C. Tasende ◽  
P. Puime ◽  
E. G. Garófalo
Keyword(s):  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
Binding Assay ◽  
Binding Capacity ◽  
Longitudinal Axis ◽  
Oestrous Cycle ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Functional Differences ◽  
Mrna Concentration

The aim of the present work was to study the oestrogen receptor (ER) and progesterone receptor (PR) binding capacity and the oestrogen receptor alpha (ERα) mRNA concentration in cranial and caudal cervix during the ovine oestrous cycle. Cervical samples of synchronised Corriedale ewes were obtained on Day 1 (n = 7), 6 (n = 6) or 13 (n = 7) after oestrus detection (Day 0). The ER and PR binding capacity by ligand-binding assay and the ERα mRNA concentration by solution hybridisation in both cranial and caudal zones of the cervix were determined. The ER and PR binding capacity were higher (P < 0.005) on Day 1 than on Days 6 and 13 in both cranial and caudal zones. The ERα mRNA concentrations were higher (P < 0.0001) on Day 1 than on Days 6 and 13 only in the caudal zone. The PR binding capacity and ERα mRNA concentration were higher (P < 0.005) in the caudal than in the cranial zone on Day 1. The ER and PR expression in the ovine cervix varied during the oestrous cycle in agreement with the known upregulation exerted by oestrogen and downregulation exerted by progesterone. Differences in ER and PR expression along the longitudinal axis of the ovine cervix were found, reflecting histological and functional differences between the cranial and caudal zones.

scholarly journals Oestrogen Receptor Alpha and Progesterone Receptor in Uterus and Ovaries on Different Days of The Oestrus Cycle in Hyperthyroid Rats

2014 ◽  
Vol 6 (4) ◽  
pp. 14-20
Author(s):  
Halil Bozoglu ◽  
Turan Karaca
Keyword(s):  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
Control Group ◽  
Albino Rats ◽  
Luminal Epithelium ◽  
Free T4 ◽  
Receptor Alpha ◽  
Oestrus Cycle ◽  
Oestrogen Receptor Alpha ◽  
Wistar Albino Rats

Background: The present study evaluated, in different oestrus cycle phases, the oestrogen receptor alpha (ERα) and progesterone receptor (PgR) in rates with hyperthyroid ovaries and uterus.Materials and Methods: Sixty-four adult female wistar albino rats were used. Animals were randomly separated into eight different groups, four of which constituted the control group and the other four of which were the actual experimental group. Hyperthyroidism was induced by daily s.c. injection of L-thyroxine (L-T4, 250 µg/kg) for 21 days.Results: Hyperthyroidism induced decreased plasma TSH levels and increased plasma free T4 levels (P < 0.001). In addition, it increased plasma oestrogen levels in all cycle phases, and plasma progesterone levels increased in different cycle phases, excluding the oestrus phase, in rats (P < 0.01). By the end of the experiment, ERα percentages were decreased in oestrus days in uterine luminal epithelium; however, ERα percentages were increased in metoestrus phases in hyperthyroid rats. ERα was elevated in proestrus, metoestrus and dioestrus phases in the corpus luteum, and hyperthyroidism also increased ERα percentages in theca folliculi. In uterine luminal epithelium, the hyperthyroidism group showed higher expressions of PgR (P < 0.05) in oestrus and metoestrus phases and decreased oestrus phase compared to control rats.Conclusions: As a result, we conclude that both the levels of plasma estrogen and progesterone as well as the differences in the distributions of relevant receptors in ovarian and uterus tissues have an impact on female infertility due to hyperthyroidism.  DOI: http://dx.doi.org/10.3126/ajms.v6i4.11816 Asian Journal of Medical Sciences Vol.6(4) 2015 14-20

scholarly journals Expression of oxytocin, oestrogen and progesterone receptors in uterine biopsy samples throughout the oestrous cycle and early pregnancy in cows

Reproduction ◽  
2001 ◽  
pp. 965-979 ◽  
Author(s):  
RS Robinson ◽  
GE Mann ◽  
GE Lamming ◽  
DC Wathes
Keyword(s):  
Progesterone Receptor ◽  
Early Pregnancy ◽  
Oestrogen Receptor ◽  
Expression Patterns ◽  
Oestrous Cycle ◽  
Receptor Expression ◽  
Luminal Epithelium ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Oxytocin Receptors

This study examined the expression patterns of oxytocin and steroid receptors in the bovine endometrium during the oestrous cycle and early pregnancy to elucidate their respective roles in the regulation of luteolysis and the maternal recognition of pregnancy. In Expt 1, uterine biopsies were collected from four cows throughout three oestrous cycles each, to provide daily samples. In Expt 2, uterine tissue was collected on days 12, 14, 16 and 18 of the oestrous cycle (n = 20) or early pregnancy (n = 16). Oxytocin receptor, oestrogen receptor alpha and progesterone receptor mRNAs were localized by in situ hybridization, and localization of oestrogen receptor and progesterone receptor was confirmed by immunocytochemistry. All three receptors showed time- and cell-specific expression patterns. Oestrogen receptor alpha increased in all regions at oestrus but high concentrations were also found in the luminal epithelium during the mid-luteal phase and in the deep glands throughout the oestrous cycle. Progesterone receptor expression was higher in the stroma than it was in the types of epithelial cell, and increased expression was observed at oestrus and during the early luteal phase. The cyclical upregulation of oxytocin receptors in the luminal epithelium on about day 16 was not related to preceding changes in the endometrial expression of either oestradiol alpha or progesterone receptors. During early pregnancy, oxytocin receptor expression was suppressed. Oestrogen receptor a concentrations increased in the non-pregnant cows and decreased in the pregnant cows between days 16 and 18, but these changes followed rather than preceded the upregulation of oxytocin receptors in the non-pregnant cows. It is concluded that the initial upregulation of oxytocin receptors in the luminal epithelium, which triggers luteolysis, is not associated directly with changes in expression of oestrogen receptor alpha.

A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer

2000 ◽  
Vol 89 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Janice M. Knowlden ◽  
Julia M.W. Gee ◽  
John F.R. Robertson ◽  
Ian O. Ellis ◽  
Robert I. Nicholson
Keyword(s):  
Breast Cancer ◽  
Oestrogen Receptor ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Clinical Breast

Oestrogen receptor alpha expression in neovaginal tissue of women following modified Abbé-McIndoe technique and in premenopausal women

2015 ◽  
Vol 31 (4) ◽  
pp. 327-331
Author(s):  
Marcio Masashi Kajikawa ◽  
Zsuzsanna Ilona Katalin Jármy-Di Bella ◽  
Juliane Dornelas ◽  
Luciana Campanatti Crema ◽  
Cláudia Cristina Takano ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Premenopausal Women ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha
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