A review of the literature on post-operative pain in older cancer patients

2007 ◽  
Vol 43 (15) ◽  
pp. 2222-2230 ◽  
Author(s):  
Y.C. Looi ◽  
R.A. Audisio
Keyword(s):  
Cancer Patients ◽  
Review Of The Literature ◽  
Post Operative Pain ◽  
Older Cancer Patients

scholarly journals Cancer Pain and Depression: A Systematic Review of Age-Related Patterns

2007 ◽  
Vol 12 (3) ◽  
pp. 205-211 ◽  
Author(s):  
Lucia Gagliese ◽  
Lynn R Gauthier ◽  
Gary Rodin
Keyword(s):  
Systematic Review ◽  
Cancer Pain ◽  
Cancer Patients ◽  
Review Of The Literature ◽  
Exclusion Criteria ◽  
Age Related ◽  
Background Pain ◽  
Prevalence Of Depression ◽  
Older Cancer Patients ◽  
Quality And Outcomes

BACKGROUND: Pain is a common and debilitating symptom experienced by cancer patients of all ages. Cancer pain is associated with elevated levels of depression; however, age-related patterns in this relationship remain unclear. This information is important to provide effective palliation of pain and depression to the growing numbers of older cancer patients.OBJECTIVE: To provide a systematic review of the literature regarding age-related patterns in the intensity or prevalence of depression among cancer patients with pain.METHODS: Medical and psychological literature databases were searched to identify eligible studies. The methodological quality and outcomes of the studies were compiled and systematically reviewed.RESULTS: Five articles, describing four studies, met the inclusion and exclusion criteria. Due to high levels of cross-study methodological variability, a qualitative review was undertaken. Three of the four studies did not find evidence for age-related patterns in depression. The fourth study found that depression increased with age.CONCLUSION: The weight of the evidence suggests that younger and older cancer patients with pain report comparable levels of depression. However, this conclusion remains preliminary due to the methodological limitations of the available studies. Research is needed to more adequately address this important issue.

Educating older cancer patients about chemotherapy: What they want is what they get?

2006 ◽  
Author(s):  
J. Jansen ◽  
J. van Weert ◽  
S. van Dulmen ◽  
T. Heeren ◽  
J. M. Bensing
Keyword(s):  
Cancer Patients ◽  
Older Cancer Patients

Radiation therapy for older cancer patients

Aging Health ◽  
2006 ◽  
Vol 2 (6) ◽  
pp. 919-930 ◽  
Author(s):  
Ajay Sandhu ◽  
Arno J Mundt
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Older Cancer Patients

The burden of polypharmacy and drug–drug interactions in older cancer patients treated with immunotherapy

2021 ◽  
pp. 107815522110120
Author(s):  
Deniz C Guven ◽  
Gozde Kavgaci ◽  
Oktay H Aktepe ◽  
Hasan C Yildirim ◽  
Taha K Sahin ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Cancer Patients ◽  
Injury Risk ◽  
Checkpoint Inhibitors ◽  
High Rate ◽  
Potentially Inappropriate Medications ◽  
Inappropriate Prescription ◽  
Prescription Practices ◽  
Increased Risk ◽  
Older Cancer Patients

Introduction Polypharmacy is a common problem in older cancer patients, although the data about polypharmacy and potentially inappropriate prescription practices is limited in patients treated with immune checkpoint inhibitors (ICIs). Therefore, we aimed to evaluate the polypharmacy frequency and drug-drug interactions in older cancer patients (≥65 years) treated with ICIs. Methods A total of 70 geriatric patients with advanced cancer were included. The polypharmacy was defined as regular use of 5 or more drugs. The START/STOPP Criteria Version 2 was used for the potentially inappropriate medications (PIM) and potential prescription omissions (PPO). The Medscape Drug Interaction Checker was used for potential drug-drug interactions. Results The patients had a median of 6 regular drugs, and polypharmacy was present in 77.1%. The polypharmacy risk was significantly increased in patients over 75 years of age (p = 0.028) and with opioid use (p = 0.048). The 50% of patients had category D or X interactions. Patients with higher Charlson Comorbidity Index had significantly increased risk for drug interactions (CCI ≤10 vs. >10, p = 0.017). The PIMs were present in 44.3% and the PPOs in 68.6% of the patients. While the overall survival and immune related adverse events were similar according to polypharmacy, in patients using seven or more drugs, the acute kidney injury risk was increased (HR: 4.667, p = 0.038). Conclusion In this study, we observed a high rate of polypharmacy and inappropriate prescription practices in ICI-treated patients. These issues pointed out the need for improved general medical care and attention for better comedication management in ICI-treated patients.

Sign in / Sign up

Export Citation Format

Share Document