Adverse effects to quality of life arising from treatment can recover with intermittent androgen suppression in men with prostate cancer

2006 ◽  
Vol 42 (8) ◽  
pp. 1083-1092 ◽  
Author(s):  
N.A. Spry ◽  
L. Kristjanson ◽  
B. Hooton ◽  
L. Hayden ◽  
G. Neerhut ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Adverse Effects ◽  
Intermittent Androgen Suppression ◽  
Androgen Suppression

scholarly journals Quality-of-Life Impact of Primary Treatments for Localized Prostate Cancer in Patients Without Hormonal Treatment

2010 ◽  
Vol 28 (31) ◽  
pp. 4687-4696 ◽  
Author(s):  
Yolanda Pardo ◽  
Ferran Guedea ◽  
Ferrán Aguiló ◽  
Pablo Fernández ◽  
Víctor Macías ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Urinary Incontinence ◽  
Sexual Dysfunction ◽  
Radical Prostatectomy ◽  
Adverse Effects ◽  
Hormonal Treatment ◽  
External Radiotherapy

Purpose Earlier studies evaluating the effect on quality of life (QoL) of localized prostate cancer interventions included patients receiving adjuvant hormone therapy, which could have affected their outcomes. Our objective was to compare the QoL impact of the three most common primary treatments on patients who were not receiving adjuvant hormonal treatment. Patients and Methods This was a prospective study of 435 patients treated with radical prostatectomy, external-beam radiotherapy, or brachytherapy. QoL was assessed before and after treatment with the Short Form-36 and the Expanded Prostate Cancer Index Composite. Differences between groups were tested by analysis of variance. Distribution of outcome at 3 years was examined by stratifying according to baseline status. Generalized estimating equation models were constructed to assess the effect of treatment over time. Results Compared with the brachytherapy group, the prostatectomy group showed greater deterioration on urinary incontinence and sexual scores but better urinary irritative-obstructive results (−18.22, −13.19, and +6.38, respectively, at 3 years; P < .001). In patients with urinary irritative-obstructive symptoms at baseline, improvement was observed in 64% of those treated with nerve-sparing radical prostatectomy. Higher bowel worsening (−2.87, P = .04) was observed in the external radiotherapy group, with 20% of patients reporting bowel symptoms. Conclusion Radical prostatectomy caused urinary incontinence and sexual dysfunction but improved pre-existing urinary irritative-obstructive symptoms. External radiotherapy and brachytherapy caused urinary irritative-obstructive adverse effects and some sexual dysfunction. External radiotherapy also caused bowel adverse effects. Relevant differences between treatment groups persisted for up to 3 years of follow-up, although the difference in sexual adverse effects between brachytherapy and prostatectomy tended to decline over long-term follow-up. These results provide valuable information for clinical decision making.

Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review

2014 ◽  
Vol 32 (4) ◽  
pp. 335-346 ◽  
Author(s):  
Jason R. Gardner ◽  
Patricia M. Livingston ◽  
Steve F. Fraser
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Systematic Review ◽  
Adverse Effects ◽  
Androgen Deprivation Therapy ◽  
Bone Health ◽  
Cardiometabolic Risk ◽  
Androgen Deprivation ◽  
Cochrane Library

Purpose Androgen-deprivation therapy is a commonly used treatment for men with prostate cancer; however, the adverse effects can be detrimental to patient health and quality of life. Exercise has been proposed as a strategy for ameliorating a range of these treatment-related adverse effects. We conducted a systematic review of the literature regarding the effects of exercise on treatment-related adverse effects in men receiving androgen-deprivation therapy for prostate cancer. Methods An online electronic search of the Cochrane Library, EMBASE, MEDLINE, CINAHL, SPORTDiscus, and Health Source databases was performed to identify relevant peer-reviewed articles published between January 1980 and June 2013. Eligible study designs included randomized controlled trials as well as uncontrolled trials with pre- and postintervention data. Information was extracted regarding participant and exercise intervention characteristics as well as the effects of exercise on bone health, body composition, physical performance, cardiometabolic risk, fatigue, and quality of life. Results Ten studies were included, with exercise interventions involving aerobic and/or resistance training. Exercise training demonstrated benefits in muscular strength, cardiorespiratory fitness, functional task performance, lean body mass, and fatigue, with inconsistent effects observed for adiposity. The impact of exercise on bone health, cardiometabolic risk markers, and quality of life are currently unclear. Conclusion Among patients with prostate cancer treated with androgen-deprivation therapy, appropriately prescribed exercise is safe and may ameliorate a range of treatment-induced adverse effects. Ongoing research of high methodologic quality is required to consolidate and expand on current knowledge and to allow the development of specific evidence-based exercise prescription recommendations.

scholarly journals Combined Resistance and Aerobic Exercise Program Reverses Muscle Loss in Men Undergoing Androgen Suppression Therapy for Prostate Cancer Without Bone Metastases: A Randomized Controlled Trial

2010 ◽  
Vol 28 (2) ◽  
pp. 340-347 ◽  
Author(s):  
Daniel A. Galvão ◽  
Dennis R. Taaffe ◽  
Nigel Spry ◽  
David Joseph ◽  
Robert U. Newton
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Muscle Strength ◽  
Aerobic Exercise ◽  
Usual Care ◽  
Physical Function ◽  
Lean Mass ◽  
Exercise Program ◽  
Androgen Suppression

Purpose Androgen suppression therapy (AST) results in musculoskeletal toxicity that reduces physical function and quality of life. This study examined the impact of a combined resistance and aerobic exercise program as a countermeasure to these AST-related toxicities. Patients and Methods Between 2007 and 2008, 57 patients with prostate cancer undergoing AST (commenced > 2 months prior) were randomly assigned to a program of resistance and aerobic exercise (n = 29) or usual care (n = 28) for 12 weeks. Primary end points were whole body and regional lean mass. Secondary end points were muscle strength and function, cardiorespiratory capacity, blood biomarkers, and quality of life. Results Analysis of covariance was used to compare outcomes for groups at 12 weeks adjusted for baseline values and potential confounders. Patients undergoing exercise showed an increase in lean mass compared with usual care (total body, P = .047; upper limb, P < .001; lower limb, P = .019) and similarly better muscle strength (P < .01), 6-meter walk time (P = .024), and 6-meter backward walk time (P = .039). Exercise also improved several aspects of quality of life including general health (P = .022) and reduced fatigue (P = .021) and decreased levels of C-reactive protein (P = .008). There were no adverse events during the testing or exercise intervention program. Conclusion A relatively brief exposure to exercise significantly improved muscle mass, strength, physical function, and balance in hypogonadal men compared with normal care. The exercise regimen was well tolerated and could be recommended for patients undergoing AST as an effective countermeasure to these common treatment-related adverse effects.

A national study of adverse effects and global quality of life among candidates for curative treatment for prostate cancer

2012 ◽  
Vol 111 (2) ◽  
pp. 221-232 ◽  
Author(s):  
Anne E. Kyrdalen ◽  
Alv A. Dahl ◽  
Eivor Hernes ◽  
Milada Cvancarova Småstuen ◽  
Sophie D. Fosså
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Adverse Effects ◽  
Curative Treatment ◽  
National Study ◽  
Global Quality ◽  
Global Quality Of Life
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