Acute neurotoxicity in children with advanced stage B-non-Hodgkin's lymphoma and B-acute lymphoblastic leukaemia treated with the United Kingdom children cancer study group 9002/9003 protocols

2004 ◽  
Vol 40 (9) ◽  
pp. 1346-1350 ◽  
Author(s):  
A. Atra ◽  
C.R. Pinkerton ◽  
E. Bouffet ◽  
A. Norton ◽  
R. Hobson ◽  
...  
Keyword(s):  
United Kingdom ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Hodgkin's Lymphoma ◽  
Study Group ◽  
Advanced Stage ◽  
Cancer Study ◽  
The United Kingdom ◽  
Cancer Study Group ◽  
Acute Neurotoxicity

Long-term outcome in children with Hodgkin’s lymphoma: The United Kingdom Children’s Cancer Study Group HD82 trial

2007 ◽  
Vol 43 (7) ◽  
pp. 1171-1179 ◽  
Author(s):  
Michael Capra ◽  
Martin Hewitt ◽  
Martin Radford ◽  
Janis Hayward ◽  
Claire L. Weston ◽  
...  
Keyword(s):  
United Kingdom ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Study Group ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cancer Study ◽  
The United Kingdom ◽  
Cancer Study Group

scholarly journals Does histology influence outcome in childhood Hodgkin's disease? Results from the United Kingdom Children's Cancer Study Group.

1997 ◽  
Vol 15 (7) ◽  
pp. 2622-2630 ◽  
Author(s):  
A G Shankar ◽  
S Ashley ◽  
M Radford ◽  
A Barrett ◽  
D Wright ◽  
...  
Keyword(s):  
United Kingdom ◽  
Prognostic Factor ◽  
Relapse Rate ◽  
Stage I ◽  
Study Group ◽  
Local Irradiation ◽  
Histologic Subtype ◽  
Cancer Study ◽  
The United Kingdom ◽  
Cancer Study Group

PURPOSE Histology has been identified as an important prognostic factor in Hodgkin's disease (HD) in adults. Information regarding the impact of histology on outcome in childhood HD is scarce. This study determines the effect of histology on the overall survival (OS) or progression-free survival (PFS) in a national series of children treated in a standardized manner. PATIENTS AND METHODS The results of treatment of 331 assessable patients, treated between January 1, 1982 and June 30, 1992, in the United Kingdom Children's Cancer Study Group (UKCCSG) Hodgkin's study I were reviewed to evaluate OS, PFS, and deaths according to stage and histology. Treatment was either involved-field radiation alone (stage IA) or chlorambucil, vinblastine, procarbazine, and prednisolone (ChlVPP) chemotherapy with or without mediastinal radiation. All were clinically staged at diagnosis. RESULTS Nodular sclerosing (NS) HD was the most common histologic subtype (155 of 331 patients [47%]) and was uniformly distributed through all stages. Lymphocyte-depletion (LD) HD was extremely uncommon (< 1%). Mixed-cellularity (MC) HD had the highest relapse rate, but this was only significant (P < .05) in stage I patients who received local irradiation alone. There was no other statistically significant difference in OS and PFS between the various histologic subtypes. Multivariate analysis for PFS and OS confirmed that stage was the most important prognostic factor and that histology did not have an effect after stratification by stage. CONCLUSION This study demonstrates that with effective multiagent chemotherapy, histologic subtype does not influence outcome. The high relapse rates in stage I MC subtype indicates that MC HD is biologically aggressive and systemic treatment with or without local irradiation may be indicated. The high relapse rate in stage IV patients appeared to be independent of histology.

Sign in / Sign up

Export Citation Format

Share Document