The doxorubicin-streptozotocin combination for the treatment of advanced well-differentiated pancreatic endocrine carcinoma

2004 ◽  
Vol 40 (4) ◽  
pp. 515-520 ◽  
Author(s):  
Th. Delaunoit ◽  
M. Ducreux ◽  
V. Boige ◽  
C. Dromain ◽  
J.-C. Sabourin ◽  
...  
Keyword(s):  
Endocrine Carcinoma ◽  
Well Differentiated ◽  
Pancreatic Endocrine Carcinoma

Phase II study of first-line FOLFIRI for progressive metastatic well-differentiated pancreatic endocrine carcinoma

2011 ◽  
Vol 43 (11) ◽  
pp. 912-916 ◽  
Author(s):  
Hedia Brixi-Benmansour ◽  
Jean-Louis Jouve ◽  
Emmanuel Mitry ◽  
Franck Bonnetain ◽  
Bruno Landi ◽  
...  
Keyword(s):  
Phase Ii ◽  
Phase Ii Study ◽  
First Line ◽  
Endocrine Carcinoma ◽  
Well Differentiated ◽  
Pancreatic Endocrine Carcinoma

Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia

1986 ◽  
Vol 408 (5) ◽  
pp. 497-503 ◽  
Author(s):  
Hartmut Arps ◽  
Manfred Dietel ◽  
Andreas Schulz ◽  
Hilde Janzarik ◽  
G�nther Kl�ppel
Keyword(s):  
Endocrine Carcinoma ◽  
Pancreatic Endocrine Carcinoma

Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis — A case report

Pancreatology ◽  
2005 ◽  
Vol 5 (2-3) ◽  
pp. 295-299 ◽  
Author(s):  
George Marakis ◽  
Konstantinos Ballas ◽  
Savas Rafailidis ◽  
Michael Alatsakis ◽  
Kalliopi Patsiaoura ◽  
...  
Keyword(s):  
Case Report ◽  
Endocrine Carcinoma ◽  
Pancreatic Endocrine Carcinoma

scholarly journals Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma

2009 ◽  
Vol 16 (2) ◽  
pp. 585-597 ◽  
Author(s):  
Cosimo Durante ◽  
Houda Boukheris ◽  
Clarisse Dromain ◽  
Pierre Duvillard ◽  
Sophie Leboulleux ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Metastatic Disease ◽  
Somatostatin Receptor ◽  
Stage Iv ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Prognostic Features ◽  
Endocrine Carcinoma ◽  
Initial Surgery ◽  
Well Differentiated

Survival of metastatic gastroenteropancreatic well-differentiated endocrine carcinoma (GEP WDEC) is not well characterized. We evaluated the long-term outcome and prognostic factors for survival in 118 patients with distant metastases from GEP WDEC. Inclusion criteria were 1) pathological review by a single pathologist according to the present WHO criteria, 2) absence of previous therapy apart from surgery, 3) complete morphological evaluation within 3 months including somatostatin receptor scintigraphy, and 4) follow-up at Gustave-Roussy Institute until death or study's end. Clinical, biological marker, and pathological parameters were analyzed in univariate and multivariate statistical models. Survival after the first complete imaging work-up of the metastatic disease was determined using Kaplan–Meier method. Overall, survival for 5 years after the diagnosis of metastatic disease was 54%. In multivariate analysis, age (hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.01–1.08, P=0.01), the number of liver metastases (HR: 3.4, 95% CI: 1.4–8.3, P=0.01), tumor slope (HR: 1.1, 95% CI: 1.0–1.1, P=0.001), and initial surgery (HR: 0.3, 95% CI: 0.1–0.8, P=0.01) were predictive of survival. Five-year survival was 100%, 91% (95% CI, 51–98%), 62% (95% CI, 37–83%), and 9% (95% CI, 6–32%) when patients had 0, 1, 2, 3 or more poor prognostic features respectively. This study enables the stratification of metastatic GEP WDEC patients into distinct risk groups. These risk categories can be used to tailor therapeutic approaches and also to design and interpret clinical trials.

scholarly journals Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst

2013 ◽  
Vol 97 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Kazuhiro Takahashi ◽  
Ryoko Sasaki ◽  
Yukio Oshiro ◽  
Kiyoshi Fukunaga ◽  
Tatsuya Oda ◽  
...  
Keyword(s):  
Bile Duct ◽  
Choledochal Cyst ◽  
Extrahepatic Bile Duct ◽  
Laboratory Data ◽  
World Health ◽  
Congenital Choledochal Cyst ◽  
Endocrine Carcinoma ◽  
Intrahepatic Bile Ducts ◽  
Extrahepatic Bile Duct Resection ◽  
Well Differentiated

Abstract We encountered a rare case of a well-differentiated endocrine carcinoma originating from the bile duct in association with a congenital choledochal cyst (CCC). The patient is a 28-year-old woman referred to our clinic for pruritus. Laboratory data showed mild elevation of serum hepatobiliary enzymes. Computed tomography and magnetic resonance imaging demonstrated pancreatobiliary maljunction and a Todani type IV-A CCC from the inferior bile duct to the bilateral intrahepatic bile ducts. A solid tumor was detected in the middle portion of the common bile duct. Pancreatoduodenectomy and total extrahepatic bile duct resection was performed. Based on pathologic and immunohistochemical examinations, a diagnosis of well-differentiated endocrine carcinoma was made according to the World Health Organization criteria. To our knowledge, this is the third report of a neuroendocrine tumor originating from the bile duct in association with a CCC.

scholarly journals A CASE OF PANCREATIC ENDOCRINE CARCINOMA CAUSING CHEST WALL METASTASIS

2011 ◽  
Vol 72 (2) ◽  
pp. 478-482
Author(s):  
Shuichi FUKUDA ◽  
Hidenori TAKAHASHI ◽  
Hiroaki OHIGASHI ◽  
Osamu ISHIKAWA ◽  
Jiro OKAMI ◽  
...  
Keyword(s):  
Chest Wall ◽  
Endocrine Carcinoma ◽  
Pancreatic Endocrine Carcinoma
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