scholarly journals Signet ring cell-rich microcystic stromal tumor of the ovary: A poorly recognized variant

2020 ◽  
Vol 22 ◽  
pp. 200451
Author(s):  
Yasuji Yoshikawa ◽  
Yuichi Nakazono ◽  
Kenichiro Hirotani ◽  
Hirofumi Kawanaka
2020 ◽  
Vol 7 (1) ◽  
pp. 30
Author(s):  
Maria Cecilia Vivar ◽  
Evelyn Carolina Polanco Jacome ◽  
Adam James Robin

A gastrointestinal stromal tumor (GIST) with signet ring cell features is a rare variant of epithelioid GIST. The current case demonstrates a 35-year-old woman with a 22.0 cm stomach mass. Tomography-guided core biopsy of the mass showed an undifferentiated tumor with abundant signet ring cells in a myxoid background. A preliminary diagnosis of adenocarcinoma was considered based on histomorphologic features; however, by immunohistochemistry studies the tumor cells were negative for cytokeratins and intensely positive for CD117/c-kit and CD34. Therefore a diagnosis of GIST with signet ring-like cells features was rendered. Making a diagnosis in a small biopsy specimen is always challenging, due to the variable histomorphological features of these tumors.


2018 ◽  
Vol 34 (3) ◽  
pp. 154-158
Author(s):  
Cihan Comba ◽  
Gokhan Demırayak ◽  
Sakir Volkan Erdogan ◽  
Zehra Sibel Kahraman ◽  
Isa Aykut Ozdemır

2017 ◽  
Vol 25 (8) ◽  
pp. 739-744
Author(s):  
Meral Uner ◽  
Alp Usubutun

Sclerosing stromal tumors of the ovary are very rare. We report the case of a 29-year-old pregnant woman who presented with a history of preterm labor and gestational hypertension. A huge mass measuring 30 cm in greatest dimension was recognized on the right ovary during cesarean section. Signet ring cell infiltration was seen during intraoperative frozen section consultation. She underwent a right salpingo-oophorectomy, and the permanent diagnosis was sclerosing stromal tumor infiltrated by signet ring cells. Pregnancy-related changes were seen in tumor morphology. Signet ring cells were immunoreactive with antibodies MUC5ac, MUC2, and EMA. Thus, stromal cells were immunoreactive with antibodies inhibin and calretinin. Endoscopic biopsy of the stomach showed a signet ring cell carcinoma, from which the metastasis had originated. This is the first reported case in the literature, and is notable for its challenging differential diagnosis, which included a pregnancy luteoma and primary signet ring stromal tumor of the ovary.


Author(s):  
Amanda Moyer ◽  
Jae Ro ◽  
Luan Truong ◽  
Diana Liang ◽  
Wade Rosenberg ◽  
...  

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