scholarly journals Ductal invasive carcinoma arising within atypical microglandular adenosis in a patient with BRCA-1 mutation: A case report

2017 ◽  
Vol 8 ◽  
pp. 41-45
Author(s):  
Costantino Ricci ◽  
Margherita Serra ◽  
Francesca Locatelli ◽  
Marco Di Laudo ◽  
Roberta Zuntini ◽  
...  
Keyword(s):  
Case Report ◽  
Invasive Carcinoma ◽  
Ductal Invasive Carcinoma ◽  
Brca 1 ◽  
Microglandular Adenosis

scholarly journals Schirrous invasive ductal carcinoma of the breast overexpress p53 oncoprotein

2001 ◽  
Vol 119 (1) ◽  
pp. 04-06 ◽  
Author(s):  
Flávia Silva Ferrini ◽  
Marcos Antonio Rossi ◽  
Mário Mourão Neto ◽  
Fernando Augusto Soares
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Biological Markers ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Progesterone Receptors ◽  
Adult Women ◽  
Estrogen And Progesterone Receptors ◽  
Desmoplastic Reaction ◽  
Ductal Invasive Carcinoma ◽  
The Relationship

CONTEXT: Breast cancer is the most important neoplasm in adult women, and its worldwide incidence is growing. The tumoral stroma is very important for modulating the growth and invasion of the tumor itself. The relationship between these two components is not completely understood. Schirrous carcinoma is a variant of ductal invasive carcinoma in which the stroma is very desmoplastic, and the importance of this finding still a motive for debate in the literature. OBJECTIVE: To compare the desmoplastic reactions against biological markers, such as estrogen and progesterone receptors, oncoprotein c-erbB-2 and oncoprotein p53, with the objective of studying the relationship between the tumoral stroma and epithelial cancer cells. TYPE OF STUDY: Retrospective study. SETTING: Cancer Hospital A C Camargo and Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. SAMPLE: 107 adult women operated because of ductal invasive carcinoma. The cases were separated into 4 groups according to the desmoplastic reaction -- less than 15%, between 15-50%, 51-85%, and more than 85% fibrosis. The grade of fibrosis was determined by picrus-sirius staining and quantified by using a microscope with a stereo-imaging grid. Immunohistochemical methods were used to determine the expression of the hormonal receptors and c-erbB-2/p53 oncoprotein. MAIN MEASUREMENTS: Extent of desmoplastic reaction versus expression of estrogen and progesterone receptors, oncoprotein c-erbB-2, and oncoprotein p53. RESULTS: The results showed that schirrous carcinoma expresses oncoprotein p53 more frequently than other carcinomas with less extensive desmoplastic reaction. There were no differences between the grade of fibrosis and the other biological markers. CONCLUSION: The intense stromatous reaction in invasive ductal carcinoma may modulate the expression of p53. Further investigations should be made with the aim of understanding how this expression determines the proliferative activity in schirrous carcinoma, and whether this overexpression is secondary to mutation of the p53 gene or due to modulation of other molecules of the stroma.

Invasive carcinoma ex pleomorphic adenoma of submandibular gland: A case report

2011 ◽  
Vol 23 (4) ◽  
pp. 207-209
Author(s):  
Doh Jeing Yong ◽  
Mahadzir Mazlinda ◽  
Alias Zanariah ◽  
Balwant S. Gendeh
Keyword(s):  
Case Report ◽  
Submandibular Gland ◽  
Pleomorphic Adenoma ◽  
Invasive Carcinoma ◽  
Carcinoma Ex Pleomorphic Adenoma

Microglandular Adenosis: A Possible Non-Obligate Precursor to Breast Carcinoma With Potential to Either Luminal-Type or Basal-Type Differentiation

2019 ◽  
Vol 27 (7) ◽  
pp. 781-787 ◽  
Author(s):  
Alexander T. Damron ◽  
Katrina Korhonen ◽  
Samantha Zuckerman ◽  
Julia Tchou ◽  
Kimberly L. Dumoff ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Carcinoma ◽  
Case Reports ◽  
Unique Case ◽  
Diagnostic Pitfall ◽  
In Situ Carcinoma ◽  
Luminal Type ◽  
Basal Type ◽  
Microglandular Adenosis

Microglandular adenosis (MGA) of the breast is exceedingly rare, with only a few case reports and series published to date. Previous studies have elegantly demonstrated the progression of benign MGA to atypical MGA to MGA-in situ carcinoma to invasive carcinoma and therefore suggest MGA as a possible non-obligate precursor lesion to a subset of breast carcinomas. Immunohistochemically, MGA is negative for estrogen receptor (ER), progesterone receptor (PR), and HER2-neu oncoprotein expression, and carcinomas arising in the setting of MGA are often reported to be triple negative. In this article, we present a unique case of an ER+/PR+/HER2− invasive carcinoma associated with MGA and atypical MGA. Our case highlights the diagnostic pitfall of MGA and suggests that MGA is a heterogeneous group of lesions with potential for either luminal-type or basal-type differentiation during progression to breast carcinoma.

Immune deficiency and invasive carcinoma of the vulva in a young woman: A case report

1987 ◽  
Vol 26 (1) ◽  
pp. 112-118 ◽  
Author(s):  
B.G. Lindeque ◽  
A.E. Nel ◽  
J.P. du Toit
Keyword(s):  
Immune Deficiency ◽  
Case Report ◽  
Young Woman ◽  
Invasive Carcinoma

410 Lobular and luminal ductal invasive carcinoma of the breast – comparative molecular analysis

2010 ◽  
Vol 8 (3) ◽  
pp. 176
Author(s):  
N. Gruel ◽  
C. Lucchesi ◽  
V. Raynal ◽  
G. Pierron ◽  
P. Cottu ◽  
...  
Keyword(s):  
Molecular Analysis ◽  
Invasive Carcinoma ◽  
Carcinoma Of The Breast ◽  
Ductal Invasive Carcinoma

scholarly journals Adenomyoepithelioma with Ductal Carcinoma In Situ: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Sanjay Warrier ◽  
Sang Hwang ◽  
Martha Ghaly ◽  
Alex Matthews
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Ductal Carcinoma In Situ ◽  
Growth Pattern ◽  
Carcinoma In Situ ◽  
Breast Screening ◽  
Ductal Carcinoma ◽  
Review Of The Literature ◽  
Microglandular Adenosis

Adenomyoepithelioma (AME) with microglandular adenosis-like growth pattern and superimposed ductal carcinoma in situ (DCIS) was identified in a 55-year-old female after biopsy of an atypical lesion identified through routine breast screening. A literature review reveals that this association has rarely been described.

Sign in / Sign up

Export Citation Format

Share Document