Modeling of polychlorinated biphenyls (PCBs) in the Baltimore Harbor

2012 ◽  
Vol 242 ◽  
pp. 54-68 ◽  
Author(s):  
Jian Shen ◽  
Bo Hong ◽  
Leonard Schugam ◽  
Yuan Zhao ◽  
Jeff White
Keyword(s):  
Polychlorinated Biphenyls ◽  
Baltimore Harbor

Pesticide and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) residues in foodstuffs from Ismailia city, Egypt

2008 ◽  
pp. 1-9 ◽  
Author(s):  
N. Loutfy ◽  
M. Fuerhacker ◽  
C. Lesueur ◽  
M. Gartner ◽  
M. Tawfic Ahmed ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls

Fatty Liver and Impaired Hepatic Metabolism Alters the Congener-Specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

2020 ◽  
Author(s):  
Xueshu Li ◽  
Chun-Yun Zhang ◽  
Hans-Joachim Lehmler
Keyword(s):  
Cytochrome P450 ◽  
Polychlorinated Biphenyls ◽  
Fatty Liver ◽  
Partition Coefficients ◽  
Hepatic Metabolism ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Specific Distribution ◽  
Specific Deletion

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that are linked to adverse health outcomes. PCB tissue levels are determinants of PCB toxicity; however, it is unclear how factors, such as an altered metabolism and/or a fatty liver, affect PCB distribution in vivo. We determined the congener-specific disposition of PCBs in mice with a liver specific deletion of cytochrome P450 reductase (KO), a model of fatty liver with impaired hepatic metabolism, and wildtype (WT) mice. Male and female KO and WT mice were exposed orally to Aroclor 1254, a technical PCB mixture. PCBs were quantified in adipose, blood, brain and liver tissues by gas chromatography-mass spectrometry. PCB profiles and levels in tissues were genotype and sex dependent. PCB levels were higher in the liver from KO compared to WT mice. PCB profiles showed clear differences between tissues from the same exposure group. While experimental tissue : blood partition coefficients in KO and WT mice did not follow the trends predicted using a composition-based model, the agreement between experimental and calculated partition coefficients was still reasonable. Thus, a fatty liver and/or an impaired hepatic metabolism alter the distribution of PCBs in mice and the magnitude of the partitioning of PCBs from blood into tissues can be approximated using composition-based models.<br>

Determination of Polychlorinated Biphenyls (PCB) in Insulating Fluids

2017 ◽  
Vol 83 (11) ◽  
pp. 15-20
Author(s):  
E. S. Brodskii ◽  
◽  
A. A. Shelepchikov ◽  
G. A. Kalinkevich ◽  
E. Ya. Mir-Kadyrova ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls
Sign in / Sign up

Export Citation Format

Share Document