Natural history of moderate aortic stenosis with preserved and low ejection fraction

2021 ◽  
Author(s):  
Tomer D. Mann ◽  
Itamar Loewenstein ◽  
Eyal Ben Assa ◽  
Yan Topilsky
Keyword(s):  
Natural History ◽  
Aortic Stenosis ◽  
Ejection Fraction ◽  
History Of ◽  
Low Ejection Fraction

scholarly journals NATURAL HISTORY OF SEVERE AORTIC STENOSIS WITH PRESERVED EJECTION FRACTION: IMPACT OF TRANSVALVULAR GRADIENTS AND FLOW

2013 ◽  
Vol 61 (10) ◽  
pp. E1979
Author(s):  
Frédéric Maes ◽  
Jamila Boulif ◽  
Christophe De Meester ◽  
Julie Melchior ◽  
Bernhard Gerber ◽  
...  
Keyword(s):  
Natural History ◽  
Aortic Stenosis ◽  
Ejection Fraction ◽  
Severe Aortic Stenosis ◽  
Preserved Ejection Fraction ◽  
History Of

Abstract 15365: Natural History of Immune Checkpoint Inhibitor Associated Myocarditis With Preserved Ejection Fraction

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Joseph Nowatzke ◽  
John R Power ◽  
Wouter C Meijers ◽  
Olusola Orimoloye ◽  
Charlotte Fenioux ◽  
...  
Keyword(s):  
Natural History ◽  
Ejection Fraction ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor ◽  
Fulminant Myocarditis ◽  
Circulatory Support ◽  
Preserved Ejection Fraction ◽  
History Of ◽  
Electrical Pacing

Introduction: Immune Checkpoint Inhibitor (ICI)-associated myocarditis can be fatal, and is often characterized by arrhythmogenicity, although > 50% present with preserved ejection fraction (pEF). The natural history of ICI-myocarditis with pEF is unknown. Methods: We utilized a multicenter network of ICI-myocarditis cases spanning 12 countries to identify 83 cases of definite or probable myocarditis presenting with an EF above 50% on initial echocardiography. We further stratified patients based on continued pEF or worsening EF (rEF) during hospitalization. We compared independent variables, vital signs on presentation, and laboratory values between the two groups. Mortality was defined as those who died or were discharged to hospice within 90 days from admission. Fulminant myocarditis was defined as need for circulatory support, atrioventricular block requiring electrical pacing, ventricular tachycardia or fibrillation, or cardiac arrest while in the hospital. Results: Of the 83 patients, 15 developed a rEF; 68 maintained pEF during hospitalization. Although no significant change in heart rate was noted on presentation, systolic blood pressure was lower in the rEF group (111 vs 129, p=0.010). The rEF cohort were more prone to have a peak troponin elevation (432 vs 41, p=0.021), and to develop fulminant myocarditis (73% vs 26%, p=<0.001). Both in-hospital mortality (46% vs 17%, p=0.015) and 90-day all-cause mortality were significantly increased in those who develop a rEF (72% vs 29%, p=0.007). Overall, there was a 36.8% 90-day mortality rate for all those presenting with an initially normal EF. Conclusions: Patients with ICI-myocarditis can still have a fulminant course despite initial echocardiogram revealing EF>50%. In our database, 18% go on to develop new rEF and 73% die in the following 90 days. Decreased BP and troponin on presentation may identify patients at risk of subsequent rEF and fulminant course.

scholarly journals Natural History of Very Severe Aortic Stenosis

Circulation ◽  
2010 ◽  
Vol 121 (1) ◽  
pp. 151-156 ◽  
Author(s):  
Raphael Rosenhek ◽  
Robert Zilberszac ◽  
Michael Schemper ◽  
Martin Czerny ◽  
Gerald Mundigler ◽  
...  
Keyword(s):  
Natural History ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
History Of

33. NATURAL HISTORY OF CONGENITAL AORTIC STENOSIS

1970 ◽  
Vol 59 (s206) ◽  
pp. 51-52 ◽  
Author(s):  
LEENA TUUTERI ◽  
B. LANDTMAN
Keyword(s):  
Natural History ◽  
Aortic Stenosis ◽  
Congenital Aortic Stenosis ◽  
History Of

scholarly journals Natural history of valvular aortic stenosis.

Heart ◽  
1973 ◽  
Vol 35 (1) ◽  
pp. 41-46 ◽  
Author(s):  
S Frank ◽  
A Johnson ◽  
J Ross
Keyword(s):  
Natural History ◽  
Aortic Stenosis ◽  
Valvular Aortic Stenosis ◽  
History Of
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