scholarly journals Growth of Neonatal Hemodynamics Programs and Targeted Neonatal Echocardiography Performed by Neonatologists

2020 ◽  
Vol 33 (10) ◽  
pp. A15-A16
Author(s):  
Patrick McNamara ◽  
Wyman Lai
Author(s):  
A Burman ◽  
S Khan ◽  
A Khushu ◽  
W Kelsall

2019 ◽  
Vol 97 (3) ◽  
pp. 183-186 ◽  
Author(s):  
Ashraf Kharrat ◽  
Patrick J. McNamara ◽  
Dany Weisz ◽  
Amish Jain

In the neonatal setting, point-of-care ultrasound is increasingly being used to help clinicians with the evaluation of heart function. Practices in neonatology, particularly with regard to acute and chronic hemodynamic managements, were traditionally more driven on dogma and predefined thresholds and not always supported by demonstrable physiology. For the first time, targeted neonatal echocardiography (TNE) provided neonatal intensivists with a bedside tool that made real-time assessment of neonatal hemodynamics status feasible in even the tiniest of babies. This opened the door towards more targeted physiological driven practices, allowing us to test historical approaches to clinical problems in a more precise way. Despite the standardization of TNE training and the creation of a formalized curriculum, little attention has been paid to the establishment of an empirical framework to adjudicate scientific investigation. In this position statement, we reflect on the evolution of TNE in Canadian neonatal intensive care units, appraise its strengths and limitations, and suggest guiding principles for clinicians and researchers to consider as they take this field forward.


2013 ◽  
Vol 98 (Suppl 1) ◽  
pp. A41-A42
Author(s):  
V. Shetthalli ◽  
S. Sen ◽  
D. Wilson ◽  
S. Reddy

2015 ◽  
Vol 34 (7) ◽  
pp. 1259-1263 ◽  
Author(s):  
Andrei Harabor ◽  
Amuchou Singh Soraisham

Author(s):  
Margaret M. Vernon ◽  
Mark B. Lewin

2018 ◽  
Vol 38 (8) ◽  
pp. 1039-1045 ◽  
Author(s):  
Ismina Papadhima ◽  
Deepak Louis ◽  
Jyotsna Purna ◽  
Poorva Deshpande ◽  
Yenge Diambomba ◽  
...  

2019 ◽  
Vol 32 (7) ◽  
pp. 895-905.e2 ◽  
Author(s):  
Anne-Sophie Sillesen ◽  
Christian Pihl ◽  
Anna Axelsson Raja ◽  
Agnes S. Davidsen ◽  
Louise E. Lind ◽  
...  

2018 ◽  
Vol 23 (suppl_1) ◽  
pp. e26-e26
Author(s):  
Soume Bhattacharya ◽  
Patrick McNamara ◽  
Regan Giesinger

Abstract BACKGROUND Disseminated Herpes Simplex infection is a severe neonatal illness with high mortality and morbidity. Despite acyclovir treatment, the fulminant disease may be rapidly progressive and treatment is largely supportive. A significant proportion of neonates with this illness require intensive care support for circulatory insufficiency and hypoxic respiratory failure. Extracorporeal membrane oxygenation may be used as rescue therapy, though mortality remains high. The pathophysiological contributors to the disease phenotype, the mechanisms underlying the hemodynamic instability and therapeutic strategies to treat such cardiovascular dysfunction have not been well described. OBJECTIVES To describe patterns of cardiovascular dysfunction using targeted neonatal echocardiography and response to therapy for neonates with disseminated herpes infection in a quaternary neonatal intensive care unit. DESIGN/METHODS A cohort of all neonates with confirmed disseminated herpes simplex virus (HSV) infection admitted over the period of November 2014- April 2017 were included in this study. All neonates were evaluated by comprehensive targeted neonatal echocardiography (TnECHO) assessment within the first 24h of admission. Demographic and clinical features were collected retrospectively from the electronic medical record. All TnECHO measurements were performed by a single expert operator. Ethical approval was obtained from the institutional ethics board. RESULTS Five neonates, 3 with HSV 1 and 2 with HSV 2, were identified during the study period. All had features of profound circulatory insufficiency such as hypotension, metabolic acidosis with high lactate, oliguria/anuria, poor capillary refill etc. Three neonates had severe oxygenation failure. On functional echocardiographic assessment, we found that all cases demonstrated underfilled cardiac chambers and low cardiac outputs suggesting severe vasodilatation and third space losses. These cases were managed by aggressive volume resuscitation and use of peripheral vasoconstrictors such as Vasopressin and Nor-Epinephrine. Primary ventricular dysfunction was identified in 3 neonates, who were treated with dobutamine and/or epinephrine. Significant pulmonary hypertension was detected in three infants which prompted the use of Inhaled Nitric Oxide. Acyclovir was initiated early on. Significant cardiovascular stabilization could be achieved by such targeted hemodynamic therapy. However, in view of extensive neurological and hepatic damage, life sustaining therapy was eventually withdrawn in all of them. CONCLUSION Cardiovascular dysfunction in neonates with disseminated HSV infection may be due to either primary ventricular dysfunction, vasodilatation and third space losses or due to pulmonary hypertension. Early targeted neonatal echocardiography may enhance physiologic definition and facilitate targeted therapy. Mortality from multisystem complications, however, remains universal, which raises the question of the role of ECMO in this population.


2018 ◽  
Vol 28 (9) ◽  
pp. 1172-1174 ◽  
Author(s):  
Seigo Okada ◽  
Jun Muneuchi ◽  
Yuki Iwaya

AbstractHerein, we present the first case of dilated cardiomyopathy due to premature constriction of the ductus arteriosus. A fetal echocardiography showed narrowing in the ductus arteriosus, and colour Doppler flow mapping could not identify blood flow through the ductus. Neonatal echocardiography revealed a left ventricular dilated cardiomyopathy, and the cardiomyopathy had fully resolved at 6 months of age.


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