scholarly journals Left Ventricular Global Longitudinal Strain Can Reliably Be Measured from a Single Apical Four-Chamber View in Patients with Heart Failure

2019 ◽  
Vol 32 (2) ◽  
pp. 317-318 ◽  
Author(s):  
Fawaz Alenezi ◽  
Andrew P. Ambrosy ◽  
Matthew Phelan ◽  
Karen Chiswell ◽  
Loai Abudaqa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Chamber View ◽  
Patients With Heart Failure

Abstract 16694: Left Ventricular Global Longitudinal Strain Predicts Ventricular Arrhythmias in Patients With Implanted Cardiac Devices

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Zain Ul Abideen Asad ◽  
Brian Kliewer ◽  
Tiffany F Mao ◽  
Isma N Javed ◽  
Abdul Ghani Iqbal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Arrhythmias ◽  
Ischemic Cardiomyopathy ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Cardiac Devices ◽  
Patients With Heart Failure

Introduction: Abnormal left ventricular ejection fraction (LVEF) is the traditional parameter used to assess the risk of sudden cardiac death (SCD), but most SCD events occur in patients with LVEF >40%. Hypothesis: We hypothesized that global longitudinal strain (GLS) can predict SCD in patients with heart failure and implantable cardiac devices. Methods: This was a retrospective cohort study. Device interrogation and chart review was done for demographic, clinical and echocardiographic characteristics and assessment of outcomes; ventricular tachycardia (VT) or ventricular fibrillation (VF), all-cause mortality, cardiac hospitalizations, non-sustained VT and new atrial fibrillation (AF). Cox-regression analysis was performed for the association between GLS, other clinical and echocardiographic parameters and outcomes. Results: A total of 180 patients were included with males 176 (98%), HFrEF (LVEF<40%) 58 (33%), HFmEF (LVEF 40-50%) 37 (21%), HFpEF 83 (46%), ischemic cardiomyopathy 78 (43%) and non-ischemic cardiomyopathy 39 (22%). Over a median follow up of 31 months, 29 (16%) developed sustained VT/VF, 33 (18%) died, 55 (31%) had cardiac hospitalization, 74 (41%) had non-sustained VT and 25 (14%) developed new AF. Abnormal GLS (≥-17%) predicted VT/VF (HR=4.0, 95% CI 1.2 - 13.3, p=0.02) and mortality (HR=4.2, 95% CI 1.5 - 11.9, p=0.008) in the entire population. Notably, in the HFpEF group, abnormal GLS was the only predictor of mortality (HR=3.5, 95% CI 1.1 - 10.8, p=0.02; Figure 1). Conclusions: Abnormal GLS is a predictor of ventricular arrhythmias and mortality in patients with heart failure. In patients with HFpEF, GLS may be used for risk stratification upon further validation in larger studies.

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