Acute Effects of Passive Smoking on Left Ventricular Systolic and Diastolic Function in Healthy Volunteers

2011 ◽  
Vol 24 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Ali Dogan ◽  
Mikail Yarlioglues ◽  
Ibrahim Gul ◽  
Mehmet Gungor Kaya ◽  
Ibrahim Ozdogru ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Diastolic Function ◽  
Passive Smoking ◽  
Left Ventricular ◽  
Acute Effects ◽  
Systolic And Diastolic Function

ACUTE EFFECTS OF PASSIVE SMOKING ON SYSTOLIC AND DIASTOLIC FUNCTION IN HEALTHY VOLUNTEERS

2008 ◽  
Vol 9 (1) ◽  
pp. 266
Author(s):  
I. Ozdogru ◽  
I. Gul ◽  
M. Kaya ◽  
A. Dogan ◽  
M. Inanc ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Diastolic Function ◽  
Passive Smoking ◽  
Acute Effects ◽  
Systolic And Diastolic Function

Acute effects of doxorubicin on human left ventricular systolic and diastolic function

1989 ◽  
Vol 118 (5) ◽  
pp. 979-982 ◽  
Author(s):  
Kenneth A Brown ◽  
Alton J Blow ◽  
Robert M Weiss ◽  
James A Stewart
Keyword(s):  
Diastolic Function ◽  
Left Ventricular ◽  
Acute Effects ◽  
Systolic And Diastolic Function

Dose-Dependent Acute Effects of Passive Smoking on Left Ventricular Cardiac Functions in Healthy Volunteers

2012 ◽  
Vol 60 (2) ◽  
pp. 517-522 ◽  
Author(s):  
Mikail Yarlioglues ◽  
Mehmet Gungor Kaya ◽  
Idris Ardic ◽  
Orhan Dogdu ◽  
Hatice Yarlioglues ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Passive Smoking ◽  
Left Ventricular ◽  
Acute Effects ◽  
Cardiac Functions ◽  
Dose Dependent

Abstract 402: Vitamin C Deficiency Impairs Cardiac Function and Post-infarction Survival in the Mouse

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Adolfo G Mauro ◽  
Donatas Kraskauskas ◽  
Bassem M Mohammed ◽  
Bernard J Fisher ◽  
Eleonora Mezzaroma ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cardiac Function ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Coronary Artery Ligation ◽  
Artery Ligation ◽  
Additional Group ◽  
Gulonolactone Oxidase ◽  
Low Levels ◽  
Systolic And Diastolic Function

Introduction: L-gulonolactone oxidase (Gulo) is the rate limiting enzyme for Vitamin C (VitC) biosynthesis. Humans rely on dietary VitC for collagen synthesis, extracellular matrix formation, and tissue regeneration. VitC deficiency is an unrecognized condition and its role in cardiac homeostasis and post-acute myocardial infarction (AMI) remodeling is unknown. Hypothesis: Low levels of VitC impair cardiac function and tissue repair following AMI. Methods: Adult male Gulo -/- knockout mice (C57BL6 background, N=8) and control C57BL (N=8), which are able to synthesize VitC were used. VitC deficiency was maintained supplying low levels of VitC (30mg/l) to Gulo -/- mice in drinking water. Mice underwent M-mode and Doppler echocardiography to measure left ventricular (LV) diameters and wall thicknesses, fractional shortening (FS), E and A waves, E/A ratio, isovolumetric relaxation time (IRT) and myocardial performance index (MPI). Experimental AMI was induced by coronary artery ligation for 7 days. An additional group of Gulo -/- were mice supplemented with physiological levels of VitC (330 mg/l) and underwent AMI. Results: VitC deficient Gulo -/- mice exhibited significantly reduced LV wall thicknesses, reduced FS, and impaired diastolic function, measured as significantly reduced E/A ratio and longer IRT (Panel A, B & C). Following AMI, 100% (8/8) of deficient Gulo -/- mice died within 5 days. Supplementation with physiological levels of VitC significantly improved survival after AMI (Panel D). Conclusion: VitC deficiency impairs systolic and diastolic function. Moreover, VitC is critical for the post-AMI survival.

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