Impact of Type 2 Diabetes Mellitus on Aortic Elastic Properties in Normotensive Diabetes: Doppler Tissue Imaging Study

2006 ◽  
Vol 19 (12) ◽  
pp. 1471-1481 ◽  
Author(s):  
Hala Mahfouz Badran ◽  
Mohamed Elnoamany
Author(s):  
M. Reijrink ◽  
S. A. de Boer ◽  
C. A. te Velde-Keyzer ◽  
J. K. E. Sluiter ◽  
R. A. Pol ◽  
...  

Abstract Background While [18F]-fluordeoxyglucose ([18F]FDG) uptake is associated with arterial inflammation, [18F]-sodium fluoride ([18F]NaF) is a marker for arterial micro-calcification. We aimed to investigate the prospective correlation between both PET markers over time and whether they are prospectively ([18F]FDG) and retrospectively ([18F]NaF) related to progression of systemic arterial disease in a longitudinal study in patients with type 2 diabetes mellitus (T2DM). Methods Baseline [18F]FDG PET/Low Dose (LD) Computed Tomography (CT) scans of ten patients with early T2DM without cardiovascular history (70% men, median age 63 years) were compared with five-year follow-up [18F]NaF/LDCT scans. Systemic activity was expressed as mean target-to-background ratio (meanTBR) by dividing the maximal standardized uptake value (SUVmax) of ten arteries by SUVmean of the caval vein. CT-assessed macro-calcifications were scored visually and expressed as calcified plaque (CP) score. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV). Five-year changes were expressed absolutely with delta (Δ) and relatively with %change. Results Baseline meanTBR[18F]FDG was strongly correlated with five-year follow-up meanTBR[18F]NaF (r = 0.709, P = .022). meanTBR[18F]NaF correlated positively with ΔCPscore, CPscore at baseline, and follow-up (r = 0.845, P = .002 and r = 0.855, P = .002, respectively), but not with %change in CPscore and PWV. Conclusion This proof-of-concept study demonstrated that systemic arterial inflammation is an important pathogenetic factor in systemic arterial micro-calcification development.


2010 ◽  
Vol 23 (12) ◽  
pp. 1266-1272 ◽  
Author(s):  
Laura Ernande ◽  
Ernst R. Rietzschel ◽  
Cyrille Bergerot ◽  
Marc L. De Buyzere ◽  
Frédéric Schnell ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 461-P
Author(s):  
GERASIMOS SIASOS ◽  
PANAGIOTA K. STAMPOULOGLOU ◽  
EVANTHIA BLETSA ◽  
KONSTANTINOS BATZIAS ◽  
STAVROULA A. PASCHOU ◽  
...  

2007 ◽  
Vol 20 (5) ◽  
pp. 548-555 ◽  
Author(s):  
M GALDERISI ◽  
G DESIMONE ◽  
P INNELLI ◽  
A TURCO ◽  
S TURCO ◽  
...  

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