Patients at High Risk with Atrial Fibrillation: A Prospective and Serial Follow-up During 12 Months with Transesophageal Echocardiography and Cerebral Magnetic Resonance Imaging

2005 ◽  
Vol 18 (9) ◽  
pp. 919-924 ◽  
Author(s):  
Peter Bernhardt ◽  
Harald Schmidt ◽  
Christoph Hammerstingl ◽  
Berndt Lüderitz ◽  
Heyder Omran
Keyword(s):  
Magnetic Resonance Imaging ◽  
Atrial Fibrillation ◽  
High Risk ◽  
Magnetic Resonance ◽  
Transesophageal Echocardiography ◽  
Resonance Imaging ◽  
Cerebral Magnetic Resonance Imaging

scholarly journals Successful treatment of neuro-Behçet’s disease with infliximab: four years follow-up

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Manjinder Kaur ◽  
Emily S. Nia ◽  
Rebecca A. Millius ◽  
Dominick G. Sudano ◽  
Jeffrey R. Lisse
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Conventional Therapy ◽  
Cerebral Vasculitis ◽  
High Morbidity ◽  
Resonance Imaging ◽  
Cerebral Magnetic Resonance Imaging ◽  
Treatment Gaps ◽  
Severe Manifestation

Neuro-Behçet’s disease (NBD) is a rare but severe manifestation of Behçet’s disease. Patients with NBD tend to have high morbidity and mortality. Some patients do not respond adequately to conventional therapy (corticosteroids and immunosuppressants). This has led to treatment gaps in the therapy of NBD. There are reports in the literature of patients with Behçet’s disease responding to anti-TNF therapy. We present a case of a male patient with biopsy proven cerebral vasculitis presenting as NBD who has been in remission with near resolution of cerebral magnetic resonance imaging lesions for 4 years following treatment with infliximab and azathioprine.

scholarly journals Patent Foramen Ovale Closure Decreases the Incidence but Not the Size of New Brain Infarction on Magnetic Resonance Imaging: An Analysis of the REDUCE Trial

Stroke ◽  
2021 ◽  
Author(s):  
Steven R. Messé ◽  
Guray Erus ◽  
Michel Bilello ◽  
Christos Davatzikos ◽  
Grethe Andersen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Atrial Fibrillation ◽  
Magnetic Resonance ◽  
Patent Foramen Ovale ◽  
Infarct Volume ◽  
Brain Infarction ◽  
Foramen Ovale ◽  
Resonance Imaging ◽  
Silent Mri

Background and Purpose: Randomized patent foramen ovale closure trials have used open-label end point ascertainment which increases the risk of bias and undermines confidence in the conclusions. The Gore REDUCE trial prospectively performed baseline and follow-up magnetic resonance imaging (MRIs) for all subjects providing an objective measure of the effectiveness of closure. Methods: We performed blinded evaluations of the presence, location, and volume of new infarct on diffusion-weighted imaging of recurrent clinical stroke or new infarct (>3 mm) on T2/fluid attenuated inversion recovery from baseline to follow-up MRI at 2 years, comparing closure to medical therapy alone. We also examined the effect of shunt size and the development of atrial fibrillation on infarct burden at follow-up. Results: At follow-up, new clinical stroke or silent MRI infarct occurred in 18/383 (4.7%) patients who underwent closure and 19/177 (10.7%) medication-only patients (relative risk, 0.44 [95% CI, 0.24–0.81], P =0.02). Clinical strokes were less common in closure patients compared with medically treated patients, 5 (1.3%) versus 12 (6.8%), P =0.001, while silent MRI infarcts were similar, 13 (3.4%) versus 7 (4.0%), P =0.81. There were no differences in number, volumes, and distribution of new infarct comparing closure patients to those treated with medication alone. There were also no differences of number, volumes, and distribution comparing silent infarcts to clinical strokes. Infarct burden was also similar for patients who developed atrial fibrillation and for those with large shunts. Conclusions: The REDUCE trial demonstrates that patent foramen ovale closure prevents recurrent brain infarction based on the objective outcome of new infarcts on MRI. Only clinical strokes were reduced by closure while silent infarctions were similar between study arms, and there were no differences in infarct volume or location comparing silent infarcts to clinical strokes. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00738894.

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