Real-time 3-dimensional echocardiography for quantification of the difference in left ventricular versus right ventricular stroke volume in a chronic animal model study: Improved results using C-scans for quantifying aortic regurgitation

2004 ◽  
Vol 17 (8) ◽  
pp. 870-875 ◽  
Author(s):  
Xiaokui Li ◽  
Michael Jones ◽  
Timothy Irvine ◽  
Rosemary A Rusk ◽  
Yoshiki Mori ◽  
...  
Keyword(s):  
Animal Model ◽  
Stroke Volume ◽  
Right Ventricular ◽  
Left Ventricular ◽  
3 Dimensional ◽  
Model Study ◽  
Animal Model Study ◽  
The Difference ◽  
Dimensional Echocardiography ◽  
Right Ventricular Stroke Volume

Is Left Ventricular Diastolic Thickening Documented During Dobutamine and Pacing Stress Echocardiography Related to Myocardial Ischemia? An Animal Model Study

2002 ◽  
Vol 19 (1) ◽  
pp. 7-13
Author(s):  
Andre Schmidt ◽  
Oswaldo Cesar de Almeida Filho ◽  
Elias Mello Ayres-Neto ◽  
Joao Jose Carneiro ◽  
Jose Antonio Marin-Neto ◽  
...  
Keyword(s):  
Animal Model ◽  
Myocardial Ischemia ◽  
Stress Echocardiography ◽  
Left Ventricular ◽  
Model Study ◽  
Animal Model Study

Limitations and pitfalls in measurements of right ventricular stroke volume in an animal model of right heart failure

2015 ◽  
Vol 36 (5) ◽  
pp. 925-937 ◽  
Author(s):  
Mads Dam Vildbrad ◽  
Asger Andersen ◽  
Thomas Krarup Andersen ◽  
Sofie Axelgaard ◽  
Sarah Holmboe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Animal Model ◽  
Stroke Volume ◽  
Right Ventricular ◽  
Right Heart Failure ◽  
Right Heart ◽  
Ventricular Stroke Volume ◽  
Right Ventricular Stroke Volume

Abstract 13613: Feasibility of Single Beat Three-dimensional Echocardiography for Analysis of Right Ventricular Systolic Function in Neonatal Heart

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ikuo Hashimoto ◽  
Kazuhiro Watanabe ◽  
Keijirou Ibuki ◽  
Fukiko Ichida
Keyword(s):  
Stroke Volume ◽  
Right Ventricular ◽  
Complex Geometry ◽  
Systolic Function ◽  
Volume Data ◽  
Ecg Gating ◽  
3 Dimensional ◽  
2D Echocardiography ◽  
Dimensional Echocardiography ◽  
Full Volume

Background: The function of the right ventricle (RV) is difficult to evaluate by 2-dimensional echocardiography because it has more complex geometry and function than the left ventricle. The aim of our study was to evaluate right ventricular (RV) systolic function in the neonate using newly developed single beat 3-dimensional echocardiography (sb3DE). Method and Results: We enrolled 15 healthy or premature neonates (0 to 53 days after birth). We scanned one beat full volume using Siemens ACUSON SC2000 (Siemens AG) echocardiography with 4Z1c Full Volume transducer without ECG-gating. RV end-diastolic (RVEDV) and systolic volume (RVESV) were computed with special software dedicated to analysis for RV volume. RV ejection fraction (RVEF) and RV stroke volume (3D-RVSV) were also calculated. While RV stroke volume was also determined from the recordings of ejection blood flow velocity and diameter at the level of the pulmonary orifice in the RV outflow tract (Doppler-RVSV). Tricuspid annular plane systolic excursion (TAPSE) was also measured by 2D echocardiography. Results: It took 15 minutes for total acquisition of echo data including one beat full volume and 4 - 5 minutes to compute for RVEDV and RVESV. Full volume data were obtained successfully in all cases with average volume rate of 60 volumes / sec. RVEDV ranged from 5.1 to 10.7 ml (average 7.5 ml), RVESV ranged from 2.3 to 5.8 ml (average 3.9 ml). There was a good correlation between 3D-RVSV and Doppler-RVSV (r = 0.77). Bland-Altman plots revealed that 3D-RVSV was underestimated by an average of 1.78 ml compared to Doppler-RVSV. TAPSE positively correlated with 3D-RVEF (r = 0.58, P = 0.038). Conclusions: Newly developed sb3DE enables us to perform 3-dimensional acquisition of RV volume without ECG-gating even in neonate. However, 3D-RVSV currently tends to be underestimated in the neonatal measurement.

Recent advances in animal model experimentation in autism research

2013 ◽  
Vol 26 (5) ◽  
pp. 264-271 ◽  
Author(s):  
Mousumi Tania ◽  
Md. Asaduzzaman Khan ◽  
Kun Xia
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Human Condition ◽  
Behavioral Alterations ◽  
Important Place ◽  
Adult Mice ◽  
Recent Advances ◽  
Model Study ◽  
Disease Biology ◽  
Animal Model Study

ObjectiveAutism, a lifelong neuro-developmental disorder is a uniquely human condition. Animal models are not the perfect tools for the full understanding of human development and behavior, but they can be an important place to start. This review focused on the recent updates of animal model research in autism.MethodsWe have reviewed the publications over the last three decades, which are related to animal model study in autism.ResultsAnimal models are important because they allow researchers to study the underlying neurobiology in a way that is not possible in humans. Improving the availability of better animal models will help the field to increase the development of medicines that can relieve disabling symptoms. Results from the therapeutic approaches are encouraging remarkably, since some behavioral alterations could be reversed even when treatment was performed on adult mice. Finding an animal model system with similar behavioral tendencies as humans is thus vital for understanding the brain mechanisms, supporting social motivation and attention, and the manner in which these mechanisms break down in autism. The ongoing studies should therefore increase the understanding of the biological alterations associated with autism as well as the development of knowledge-based treatments therapy for those struggling with autism.ConclusionIn this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals.

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