Real-time myocardial contrast echocardiography for pharmacologic stress testing: is quantitative estimation of myocardial blood flow reserve necessary?

2004 ◽  
Vol 17 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Grigorios Korosoglou ◽  
K.Gaspar C da Silva ◽  
Nino Labadze ◽  
Alain-Eric Dubart ◽  
Alexander Hansen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Real Time ◽  
Stress Testing ◽  
Quantitative Estimation ◽  
Contrast Echocardiography ◽  
Pharmacologic Stress ◽  
Pharmacologic Stress Testing ◽  
Flow Reserve ◽  
Myocardial Blood Flow Reserve

scholarly journals Relationship between HgbA1c and Myocardial Blood Flow Reserve in Patients with Type 2 Diabetes Mellitus: Noninvasive Assessment Using Real-Time Myocardial Perfusion Echocardiography

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Runqing Huang ◽  
Sahar S. Abdelmoneim ◽  
Lara F. Nhola ◽  
Sharon L. Mulvagh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Flow ◽  
Type 2 Diabetes Mellitus ◽  
Myocardial Perfusion ◽  
Myocardial Blood Flow ◽  
Real Time ◽  
Flow Reserve ◽  
Myocardial Blood Flow Reserve

To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE). HgbA1c was measured at time of RTMPE. Microbubble velocity (β min−1), myocardial blood flow (MBF, mL/min/g), and myocardial blood flow reserve (MBFR) were quantified. Quantitative MCE analysis was feasible in all patients (272/384 segments, 71%). Those with HgbA1c > 7.1% had significantly lowerβreserveand MBFR than those with HgbA1c ≤ 7.1%(P<0.05). In patients with suspected CAD, there was a significant inverse correlation between MBFR and HgbA1c (r=-0.279,P=0.01); however, in those with known CAD, this relationship was not significant (r=-0.117,P=0.129). Using a MBFR cutoff value > 2 as normal, HgbA1c > 7.1% significantly increased the risk for abnormal MBFR, (adjusted odds ratio: 1.92, 95% CI: 1.12–3.35,P=0.02). Optimal glycemic control is associated with preservation of MBFR as determined by RTMPE, in T2DM patients at risk for CAD.

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