Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?

2019 ◽  
Vol 135 ◽  
pp. 23-26 ◽  
Author(s):  
Carolina Maia Silva ◽  
Maria Carolina de Moraes Pereira ◽  
Thaís Bernardes de Queiroz ◽  
Lucimara Teixeira das Neves
Keyword(s):  
Risk Factor ◽  
Oral Cleft ◽  
Parental Consanguinity

Screening of the Risk Factors for Congenital Anomalies in Pregnant Women Attending Maternity and Obstetric Hospitals at Mosul City

2021 ◽  
Vol 15 (9) ◽  
pp. 2667-2671
Author(s):  
Enam Abdulmajeed Al Taee ◽  
Salwa Hazim Almukhtar
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Congenital Anomalies ◽  
Maternal Nutrition ◽  
Study Data ◽  
Cross Sectional ◽  
Parental Consanguinity ◽  
Maternal Nutritional Status ◽  
The Social ◽  
Maternity Hospitals

To determine the possible risk factor leading to common congenital anomalies among fetuses and neonatal and assess possibly causes the lead to congenital anomalies A descriptive study (it was cross-sectional) was adopted to achieve the objectives of the current study for the period from October 16 to May 31, 2020. Data were collected from Nineveh Governorate. An objective sample of (120) women who gave birth to children with congenital anomalies in maternity wards was selected in this study. Data were prepared, organized, and entered a computer file; Statistical Package for the Social Science (SPSS, version 26). In a questionnaire for women in maternity wards in maternity hospitals in the city of Mosul, 120 women who gave birth to deformed children were monitored. Most of the risk factors were important in an association between congenital malformations and parental kinship, fever, and maternal nutrition. Malnutrition during pregnancy also shows an association between parental consanguinity and NTD. It was concluded from the available data that there is a significant association between congenital anomalies, parental consanguinity, maternal nutritional status, and high temperature during pregnancy. Support parents who have a deformed baby or are at risk of having a baby with a congenital problem, by doing basic checkups before and during pregnancy to make sure the pregnancy is healthy. Keywords: Risk Factor, Pregnant Woman, Congenital Anomalies.

Birth Prevalence of Oral Clefting in Northern Iran

2007 ◽  
Vol 44 (4) ◽  
pp. 378-380 ◽  
Author(s):  
Mohammad Jafar Golalipour ◽  
Arezo Mirfazeli ◽  
Naser Behnampour
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Birth Date ◽  
Northern Iran ◽  
Oral Clefts ◽  
Oral Cleft ◽  
Birth Prevalence ◽  
Parental Consanguinity ◽  
Live Births ◽  
Isolated Cleft Palate

Objective: To explore the prevalence of oral clefting in northern Iran. Setting: In the Dezyani hospital 37,951 live births from 1998 through 2003 were screened for oral clefts. Clinical and demographic factors of diagnosed cases, including birth date, ethnicity, type of oral cleft, parental consanguinity, and coexisting anomalies, were recorded for analysis. Results: The overall prevalence of oral clefting was 0.97 per 1000 live births. The prevalence of cleft lip with or without cleft palate and isolated cleft palate was 0.60 and 0.37 per 1000, respectively. The prevalence of oral clefting was 1.08 per 1000 male births and 0.86 per 1000 female births. With respect to parental ethnicity, the prevalence of oral clefting was 0.86, 0.88, and 1.47 per 1000 in Fars, Turkman, and Sistani, respectively. Conclusions: The prevalence of oral cleft among live births in the Dezyani hospital is similar to that reported in the previous studies for Iran and whites.

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

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