Pregnant women's cognitive appraisal of a natural disaster affects their children's BMI and central adiposity via DNA methylation: Project Ice Storm

2016 ◽  
Vol 103 ◽  
pp. 189-192 ◽  
Author(s):  
Lei Cao-Lei ◽  
Kelsey N. Dancause ◽  
Guillaume Elgbeili ◽  
David P. Laplante ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Natural Disaster ◽  
Cognitive Appraisal ◽  
Ice Storm ◽  
Central Adiposity

scholarly journals Pregnant women’s cognitive appraisal of a natural disaster affects DNA methylation in their children 13 years later: Project Ice Storm

2015 ◽  
Vol 5 (2) ◽  
pp. e515-e515 ◽  
Author(s):  
L Cao-Lei ◽  
G Elgbeili ◽  
R Massart ◽  
D P Laplante ◽  
M Szyf ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Natural Disaster ◽  
Cognitive Appraisal ◽  
Ice Storm

scholarly journals DNA methylation mediates the effect of maternal cognitive appraisal of a disaster in pregnancy on the child’s C-peptide secretion in adolescence: Project Ice Storm

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192199 ◽  
Author(s):  
Lei Cao-Lei ◽  
Kelsey N. Dancause ◽  
Guillaume Elgbeili ◽  
David P. Laplante ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cognitive Appraisal ◽  
Ice Storm ◽  
C Peptide ◽  
Peptide Secretion ◽  
In Pregnancy

scholarly journals DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 13½ years: Project Ice Storm

Epigenetics ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. 749-761 ◽  
Author(s):  
Lei Cao-Lei ◽  
Kelsey N Dancause ◽  
Guillaume Elgbeili ◽  
Renaud Massart ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Stress ◽  
Ice Storm ◽  
Central Adiposity ◽  
Prenatal Maternal Stress ◽  
The Impact

scholarly journals DNA Methylation Signatures Triggered by Prenatal Maternal Stress Exposure to a Natural Disaster: Project Ice Storm

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107653 ◽  
Author(s):  
Lei Cao-Lei ◽  
Renaud Massart ◽  
Matthew J. Suderman ◽  
Ziv Machnes ◽  
Guillaume Elgbeili ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Natural Disaster ◽  
Maternal Stress ◽  
Ice Storm ◽  
Prenatal Maternal Stress ◽  
Stress Exposure

Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans

2009 ◽  
Vol 21 (2) ◽  
pp. 343-353 ◽  
Author(s):  
Suzanne King ◽  
Adham Mancini-Marïe ◽  
Alain Brunet ◽  
Elaine Walker ◽  
Michael J. Meaney ◽  
...  
Keyword(s):  
Natural Disaster ◽  
Maternal Stress ◽  
Significant Negative Correlation ◽  
Target Group ◽  
Ice Storm ◽  
Prenatal Maternal Stress ◽  
Lower Stress ◽  
The Face ◽  
Normal Controls ◽  
Objective Stress

AbstractDermatoglyphic asymmetry of fingertip ridge counts is more frequent in schizophrenia patients than normal controls, and may reflect disruptions in fetal development during Weeks 14–22 when fingerprints develop. However, there are no data in humans linking specific adverse events at specific times to dermatoglyphic asymmetries. Our objective was to determine whether prenatal exposure to a natural disaster (1998 Quebec ice storm) during Weeks 14–22 would result in increased dermatoglyphic asymmetry in children, and to determine the roles of maternal objective stress exposure, subjective stress reaction, and postdisaster cortisol. Ridge counts for homologous fingers were scored for 77 children (20 target exposed [Weeks 14–22] and 57 nontarget exposed [exposed during other gestation weeks]). Children in the target group had more than 0.50 SD greater asymmetry than the nontarget group. Within the target group, children whose mothers had high subjective ice storm stress had significantly greater asymmetry than those with lower stress mothers, and maternal postdisaster cortisol had a significant negative correlation with the children's dermatoglyphic asymmetry (r = −.56). Prenatal maternal stress during the period of fingerprint development results in greater dermatoglyphic asymmetry in their children, especially in the face of greater maternal distress.

scholarly journals Prenatal Maternal Stress from a Natural Disaster Alters Urinary Metabolomic Profiles in Project Ice Storm Participants

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Eric J. Paxman ◽  
Naveenjyote S. Boora ◽  
Douglas Kiss ◽  
David P. Laplante ◽  
Suzanne King ◽  
...  
Keyword(s):  
Natural Disaster ◽  
Maternal Stress ◽  
Ice Storm ◽  
Prenatal Maternal Stress

scholarly journals Effect of Natural Disaster-Related Prenatal Maternal Stress on Child Development and Health: A Meta-Analytic Review

2021 ◽  
Vol 18 (16) ◽  
pp. 8332
Author(s):  
Sandra Lafortune ◽  
David P. Laplante ◽  
Guillaume Elgbeili ◽  
Xinyuan Li ◽  
Stéphanie Lebel ◽  
...  
Keyword(s):  
Child Development ◽  
Natural Disaster ◽  
Maternal Stress ◽  
Meta Analysis ◽  
Third Party ◽  
Ice Storm ◽  
Prenatal Maternal Stress ◽  
Analytic Review ◽  
Analytical Review ◽  
Meta Analyses

The evidence supporting the idea that natural disaster-related prenatal maternal stress (PNMS) influences the child’s development has been accumulating for several years. We conducted a meta-analytical review to quantify this effect on different spheres of child development: birth outcomes, cognitive, motor, physical, socio-emotional, and behavioral development. We systematically searched the literature for articles on this topic (2756 articles retrieved and 37 articles included in the systematic review), extracted the relevant data to calculate the effect sizes , and then performed a meta-analysis for each category of outcomes (30 articles included across the meta-analyses) and meta-regressions to determine the effect of some factors of interest on the association between PNMS and child development: type of PNMS (objective, psychological, cognitive, diet), type of natural disaster (ice storm, flood/cyclone), type of report (maternal, third-party observer, medical), timing of exposure (preconception exposure included or not) and child age at assessment (under 10 or 10 years and older). We found that PNMS significantly influences all spheres of child development. Higher PNMS levels were associated with longer gestational age, larger newborns, and higher BMI and adiposity levels, as well as worse cognitive, motor, socio-emotional, and behavioral outcomes.

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

Sign in / Sign up

Export Citation Format

Share Document