Brain functional network connectivity development in very preterm infants: The first six months

2016 ◽  
Vol 98 ◽  
pp. 29-35 ◽  
Author(s):  
Lili He ◽  
Nehal A. Parikh
Keyword(s):  
Preterm Infants ◽  
Network Connectivity ◽  
Functional Network ◽  
Very Preterm Infants ◽  
Functional Network Connectivity ◽  
Very Preterm ◽  
Brain Functional Network

scholarly journals Altered functional network connectivity in preterm infants: antecedents of cognitive and motor impairments?

2018 ◽  
Vol 223 (8) ◽  
pp. 3665-3680 ◽  
Author(s):  
Elveda Gozdas ◽  
Nehal A. Parikh ◽  
Stephanie L. Merhar ◽  
Jean A. Tkach ◽  
Lili He ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Network Connectivity ◽  
Functional Network ◽  
Motor Impairments ◽  
Functional Network Connectivity

scholarly journals Whole-Brain Functional Network Connectivity Abnormalities in Affective and Non-Affective Early Phase Psychosis

2021 ◽  
Vol 15 ◽  
Author(s):  
Zening Fu ◽  
Armin Iraji ◽  
Jing Sui ◽  
Vince D. Calhoun
Keyword(s):  
Early Phase ◽  
Network Connectivity ◽  
Assessment Instrument ◽  
Functional Network ◽  
State Transitions ◽  
Affective Psychosis ◽  
Whole Brain ◽  
Affective Psychoses ◽  
Functional Network Connectivity ◽  
Brain Functional Network

Psychosis disorders share overlapping symptoms and are characterized by a wide-spread breakdown in functional brain integration. Although neuroimaging studies have identified numerous connectivity abnormalities in affective and non-affective psychoses, whether they have specific or unique connectivity abnormalities, especially within the early stage is still poorly understood. The early phase of psychosis is a critical period with fewer chronic confounds and when treatment intervention may be most effective. In this work, we examined whole-brain functional network connectivity (FNC) from both static and dynamic perspectives in patients with affective psychosis (PAP) or with non-affective psychosis (PnAP) and healthy controls (HCs). A fully automated independent component analysis (ICA) pipeline called “Neuromark” was applied to high-quality functional magnetic resonance imaging (fMRI) data with 113 early-phase psychosis patients (32 PAP and 81 PnAP) and 52 HCs. Relative to the HCs, both psychosis groups showed common abnormalities in static FNC (sFNC) between the thalamus and sensorimotor domain, and between subcortical regions and the cerebellum. PAP had specifically decreased sFNC between the superior temporal gyrus and the paracentral lobule, and between the cerebellum and the middle temporal gyrus/inferior parietal lobule. On the other hand, PnAP showed increased sFNC between the fusiform gyrus and the superior medial frontal gyrus. Dynamic FNC (dFNC) was investigated using a combination of a sliding window approach, clustering analysis, and graph analysis. Three reoccurring brain states were identified, among which both psychosis groups had fewer occurrences in one antagonism state (state 2) and showed decreased network efficiency within an intermediate state (state 1). Compared with HCs and PnAP, PAP also showed a significantly increased number of state transitions, indicating more unstable brain connections in affective psychosis. We further found that the identified connectivity features were associated with the overall positive and negative syndrome scale, an assessment instrument for general psychopathology and positive symptoms. Our findings support the view that subcortical-cortical information processing is disrupted within five years of the initial onset of psychosis and provide new evidence that abnormalities in both static and dynamic connectivity consist of shared and unique features for the early affective and non-affective psychoses.

scholarly journals Altered functional network connectivity relates to motor development in children born very preterm

NeuroImage ◽  
2018 ◽  
Vol 183 ◽  
pp. 574-583 ◽  
Author(s):  
M.D. Wheelock ◽  
N.C. Austin ◽  
S. Bora ◽  
A.T. Eggebrecht ◽  
T.R. Melzer ◽  
...  
Keyword(s):  
Motor Development ◽  
Network Connectivity ◽  
Functional Network ◽  
Functional Network Connectivity ◽  
Very Preterm

scholarly journals Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Jingjing Su ◽  
Shiyu Ban ◽  
Mengxing Wang ◽  
Fengchun Hua ◽  
Liang Wang ◽  
...  
Keyword(s):  
Resting State ◽  
Network Connectivity ◽  
Functional Network ◽  
Precentral Gyrus ◽  
Functional Network Connectivity ◽  
Brain Functional Network ◽  
Z Scores ◽  
The Mean ◽  
The Right ◽  
Local Brain

Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive functioning requires the dynamic coordination of neural activity over large-scale networks. It remains unclear whether changes in resting-state brain functional network connectivity and regional homogeneities (ReHos) underly the mechanisms of executive dysfunction evident in CADASIL patients. Methods In this study, 22 CADASIL patients and 44 matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI). Independent component analysis (ICA) was used to measure functional brain network connectivity, and ReHos were calculated to evaluate local brain activities. We used seed-based functional connectivity (FC) analyses to determine whether dysfunctional areas (as defined by ReHos) exhibited abnormal FC with other brain areas. Relationships among the mean intra-network connectivity z-scores of dysfunctional areas within functional networks, and cognitive scores were evaluated using Pearson correlation analyses. Results Compared to the controls, CADASIL patients exhibited decreased intra-network connectivity within the bilateral lingual gyrus (LG) and the right cuneus (CU) (thus within the visual network [VIN)], and within the right precuneus (Pcu), inferior frontal gyrus (IFG), and precentral gyrus (thus within the frontal network [FRN]). Compared to the controls, patients also exhibited significantly lower ReHos in the right precuneus and cuneus (Pcu/CU), visual association cortex, calcarine gyri, posterior cingulate, limbic lobe, and weaker FC between the right Pcu/CU and the bilateral parahippocampal gyrus (PHG), and between the right Pcu/CU and the right postcentral gyrus. Notably, the mean connectivity z-scores of the bilateral LG and the right CU within the VIN were positively associated with compromised attention, calculation and delayed recall as revealed by tests of the various cognitive domains explored by the Mini-Mental State Examination. Conclusions The decreases in intra-network connectivity within the VIN and FRN and reduced local brain activity in the posterior parietal area suggest that patients with CADASIL may exhibit dysfunctional visuomotor behaviors (a hallmark of executive function), and that all visual information processing, visuomotor planning, and movement execution may be affected.

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