Increased nuchal translucency and congenital heart disease

2012 ◽  
Vol 88 (5) ◽  
pp. 261-267 ◽  
Author(s):  
Ritu Mogra ◽  
Nasser Alabbad ◽  
Jon Hyett
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Nuchal Translucency ◽  
Increased Nuchal Translucency

Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms

2015 ◽  
Vol 35 (6) ◽  
pp. 517-528 ◽  
Author(s):  
Nicole B. Burger ◽  
Mireille N. Bekker ◽  
Christianne J. M. de Groot ◽  
Vincent M. Christoffels ◽  
Monique C. Haak
Keyword(s):  
Systematic Review ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Nuchal Translucency ◽  
Genetic Mechanisms ◽  
Increased Nuchal Translucency

scholarly journals The link between nuchal translucency and congenital heart disease

2013 ◽  
Vol 19 (4) ◽  
pp. 206-211
Author(s):  
C. Ionescu ◽  
Diana Gheorghiu ◽  
Gabriela Iacob ◽  
H. Haradja
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Nuchal Translucency ◽  
Ductus Venosus ◽  
Flow Profile ◽  
Increased Risk ◽  
And Function ◽  
The Relationship ◽  
Increased Nuchal Translucency

Abstract The nuchal translucency is defined as a transient subcutaneous collection of fluid behind the fetal neck seen on ultrasonography at 11-14 weeks of gestation. In this current overview it was observed the relationship between increased nuchal translucency (NT) and fetal heart structure and function in chromosomally normal fetuses. Fetuses with an increases NT have an increased risk for congenital heart disease (CHD) and the combination between an increases NT, tricuspid regurgitation (TR) and an abnormal ductus venosus (DV) Doppler flow profile is a strong marker for CHD.

Abstract 16738: Association Between First and Second Trimester Maternal Screening Biochemistry, Ultrasound, and Fetal Brain Growth in Presence of Fetal or Maternal Congenital Heart Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Aman Sharma ◽  
Emma Lewis ◽  
Gabrielle Gray ◽  
Jennifer R Maldonado ◽  
Diana L Knoedel ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Brain ◽  
Nuchal Translucency ◽  
Second Trimester ◽  
Fetal Head ◽  
Placental Dysfunction ◽  
Z Scores ◽  
Hormonal Levels

Introduction: Newer research has highlighted significant neurological impairments in children and adults with congenital heart disease (CHD). The more severe the heart defect, the higher the neurologic impairment. Pregnancies complicated by fetal or maternal CHD carry a higher risk of placental abnormalities. We studied the association between pregnancy hormonal levels and fetal head and body growth. Hypothesis: Placental dysfunction in pregnancies with fetal or maternal CHD alters pregnancy hormonal levels affecting fetal brain and somatic growth. Methods: We performed a retrospective case-control study on pregnant women (year 2010-2019) at the University of Iowa. Only women with first and/or second trimester prenatal screening (ultrasound and blood test) were included. Pregnancies with fetal chromosomal abnormalities, multiple gestation, maternal diabetes, smoking, or hypertension were excluded. Pregnancies were either healthy controls (n=36), women with CHD (MCHD; n=26), or fetus with CHD (FCHD; n=23). Pregnancy hormonal levels, ultrasound findings, and fetal/neonatal growth percentiles and/or z-scores data were analyzed. Results: Women with CHD were younger (p=0.004) with increased fetal nuchal translucency (p=0.003) compared to controls. Women in MCHD (p=0.02) and FCHD (p=0.02) group delivered earlier than controls. FCHD had significantly lower pregnancy associated plasma protein-A (PAPP-A) levels than controls (p=0.04). The groups had no difference in the second trimester fetal head circumference (HC) and femur length. FCHD group had significantly smaller HC percentile (p=0.03) and z-scores (p=0.03) at birth than controls. Both FCHD and MCHD had smaller birth weight and length compared to controls. However, only FCHD group demonstrated significantly lower HC to birth weight ratio (p=0.01). The controls had a positive correlation between human chorionic gonadotropin level and head circumference z-score at birth (r=0.34;p=0.053). Conclusions: Pregnant women with CHD have increased fetal nuchal translucency and deliver at earlier gestational age. Women with fetal CHD have smaller neonatal head and body size at birth with associated low PAPP-A level early in their pregnancy probably related to placental dysfunction.

Nuchal Translucency and the Risk of Congenital Heart Disease

2007 ◽  
Vol 109 (6) ◽  
pp. 1455-1456 ◽  
Author(s):  
Jon Hyett ◽  
Jiri Sonek ◽  
Kypros Nicolaides
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Nuchal Translucency

Nuchal Translucency and the Risk of Congenital Heart Disease

2007 ◽  
Vol 109 (2, Part 1) ◽  
pp. 376-383 ◽  
Author(s):  
Lynn L. Simpson ◽  
Fergal D. Malone ◽  
Diana W. Bianchi ◽  
Robert H. Ball ◽  
David A. Nyberg ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Nuchal Translucency

Nuchal Translucency and the Risk of Congenital Heart Disease

2007 ◽  
Vol 109 (6) ◽  
pp. 1456-1457 ◽  
Author(s):  
Lynn L. Simpson ◽  
Fergal D. Malone ◽  
George R. Saade ◽  
Mary E. D’Alton
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Nuchal Translucency

Abstracts for the British Congenital Cardiac Association Annual Meeting: The Barbican, London, 24–25 November 2005: Poster Presentations: 8 Years of fetal echocardiography in high-risk mothers: The Birmingham Women’s Hospital experience

2006 ◽  
Vol 16 (3) ◽  
pp. 322-323
Author(s):  
S. V. Rasiah ◽  
A. K. Ewer ◽  
P. Miller ◽  
J. G. Wright ◽  
M. D. Kilby
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
High Risk ◽  
Congenital Heart ◽  
Fetal Echocardiography ◽  
Nuchal Translucency ◽  
Initial Screening ◽  
Affected Child ◽  
Cardiac Condition ◽  
Diabetic Mothers

Introduction: Congenital heart disease (CHD) affects 8 per 1000 live births and it is also responsible for 20% of neonatal deaths. Antenatal diagnosis of major CHD allows appropriate counselling and planning for delivery at a neonatal unit with appropriate intensive care and transport facilities. Birmingham Women’s Hospital provides a supra-regional specialist fetal echocardiography in high-risk mothers. Aim: To evaluate fetal echocardiography findings in high-risk mothers over an 8 year period. Method: We undertook a retrospective review of all pregnant women at high-risk of having a baby with congenital heart disease who underwent fetal echocardiography between 01/01/1997 and 31/12/2004 at Birmingham Women’s Hospital. Results: 3,963 mothers were referred for fetal echocardiography and a total of 5,568 fetal echocardiography examinations were carried out during this period. The main reasons for referral were: (i) previously affected child – 27% (ii) abnormal initial screening scan – 20.7% (iii) maternal cardiac condition – 9.5% (iv) infant of diabetic mothers – 8% and (v) increased fetal nuchal translucency – 3%. Seven hundred and twleve (17.9%) echocardiograms were reported as abnormal. The majority of the abnormalities were identified in mothers who had abnormal initial screening scan (62%). In addition, the echocardiogram was also abnormal in 9% of cases with increased fetal nuchal translucency and in 5.7% of infants of diabetic mothers. In those with previously affected child and maternal cardiac condition, the echocardiogram was abnormal in 2.5% and 2.6% respectively. Conclusion: Abnormal initial screening scans and increased nuchal translucency had the highest yield in identifying CHD in high-risk mothers. Infant of diabetic mothers also have an increased risk warranting fetal cardiac screening for CHD. Normal fetal echocardiogram provides reassurance for the remainder of parents.

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