scholarly journals Association between neonatal iron overload and early human brain development in premature infants

2012 ◽  
Vol 88 (8) ◽  
pp. 583-587 ◽  
Author(s):  
Sanjiv B. Amin ◽  
Gary Myers ◽  
Hongyue Wang
Keyword(s):  
Iron Overload ◽  
Human Brain ◽  
Brain Development ◽  
Premature Infants ◽  
Human Brain Development ◽  
Early Human

scholarly journals Exploring early human brain development with structural and physiological neuroimaging

NeuroImage ◽  
2019 ◽  
Vol 187 ◽  
pp. 226-254 ◽  
Author(s):  
Lana Vasung ◽  
Esra Abaci Turk ◽  
Silvina L. Ferradal ◽  
Jason Sutin ◽  
Jeffrey N. Stout ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Early Human

scholarly journals Brain anatomical networks in early human brain development

NeuroImage ◽  
2011 ◽  
Vol 54 (3) ◽  
pp. 1862-1871 ◽  
Author(s):  
Yong Fan ◽  
Feng Shi ◽  
Jeffrey Keith Smith ◽  
Weili Lin ◽  
John H. Gilmore ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Early Human

scholarly journals Early human brain development: insights into macroscale connectome wiring

2018 ◽  
Vol 84 (6) ◽  
pp. 829-836 ◽  
Author(s):  
Kristin Keunen ◽  
Hannelore K. van der Burgh ◽  
Marcel A. de Reus ◽  
Pim Moeskops ◽  
Ruben Schmidt ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Early Human

scholarly journals One-stop Microfluidic Assembly of Human Brain Organoids to Model Prenatal Cannabis Exposure

2020 ◽  
Author(s):  
Zheng Ao ◽  
Hongwei Cai ◽  
Daniel J Havert ◽  
Zhuhao Wu ◽  
Zhiyi Gong ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Developmental Disorders ◽  
Embryonic Stem ◽  
Microfluidic Platform ◽  
Cell Culture Techniques ◽  
Human Brain Development ◽  
One Stop ◽  
On Chip ◽  
Early Human

AbstractPrenatal cannabis exposure (PCE) influences human brain development, but it is challenging to model PCE using animals and current cell culture techniques. Here, we developed a one-stop microfluidic platform to assemble and culture human cerebral organoids from human embryonic stem cells (hESC) to investigate the effect of PCE on early human brain development. By incorporating perfusable culture chambers, air-liquid interface, and one-stop protocol, this microfluidic platform can simplify the fabrication procedure, and produce a large number of organoids (169 organoids per 3.5 cm x 3.5 cm device area) without fusion, as compared with conventional fabrication methods. These one-stop microfluidic assembled cerebral organoids not only recapitulate early human brain structure, biology, and electrophysiology but also have minimal size variation and hypoxia. Under on-chip exposure to the psychoactive cannabinoid, delta-9-tetrahydrocannabinol (THC), cerebral organoids exhibited reduced neuronal maturation, downregulation of cannabinoid receptor type 1 (CB1) receptors, and impaired neurite outgrowth. Moreover, transient on-chip THC treatment also decreased spontaneous firing in microfluidic assembled brain organoids. This one-stop microfluidic technique enables a simple, scalable, and repeatable organoid culture method that can be used not only for human brain organoids, but also for many other human organoids including liver, kidney, retina, and tumor organoids. This technology could be widely used in modeling brain and other organ development, developmental disorders, developmental pharmacology and toxicology, and drug screening.

Ganglioside GM1 and GM3 in early human brain development: An immunocytochemical study

1996 ◽  
Vol 14 (1) ◽  
pp. 35-44 ◽  
Author(s):  
M. Stojiljković ◽  
T. Blagojević ◽  
S. Vukosavić ◽  
N.D. Zvezdina ◽  
S. Peković ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Immunocytochemical Study ◽  
Ganglioside Gm1 ◽  
Human Brain Development ◽  
Early Human

scholarly journals Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems

2020 ◽  
Vol 11 (9) ◽  
Author(s):  
Piyush Joshi ◽  
Caroline Bodnya ◽  
Megan L. Rasmussen ◽  
Alejandra I. Romero-Morales ◽  
Anna Bright ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Neural Development ◽  
Human Cancer ◽  
Model Systems ◽  
Mitochondrial Morphology ◽  
Double Knockout ◽  
Human Brain Development ◽  
Early Human

Abstract Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for BAX and BAK in mitochondrial fission during apoptosis. BAX and BAK function in human brain development remains elusive due to the lack of appropriate model systems. Here, we generated BAX/BAK double knockout human-induced pluripotent stem cells (hiPSCs), hiPSC-derived neural progenitor cells (hNPCs), neural rosettes, and cerebral organoids to uncover the effects of BAX and BAK deletion in an in vitro model of early human brain development. We found that BAX and BAK-deficient cells have abnormal mitochondrial morphology and give rise to aberrant cortical structures. We suggest crucial functions for BAX and BAK during human development, including maintenance of homeostatic mitochondrial morphology, which is crucial for proper development of progenitors and neurons of the cortex. Human pluripotent stem cell-derived systems can be useful platforms to reveal novel functions of the apoptotic machinery in neural development.

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