The significance of under- or overweight during childhood as a risk factor for hypertensive diseases in pregnancy

2006 ◽  
Vol 82 (10) ◽  
pp. 663-668 ◽  
Author(s):  
Brigitte Leeners ◽  
Werner Rath ◽  
Sabine Kuse ◽  
Claudia Irawan ◽  
Peruka Neumaier-Wagner
2006 ◽  
Vol 111 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Brigitte Leeners ◽  
Werner Rath ◽  
Sabine Kuse ◽  
Claudia Irawan ◽  
Bruno Imthurn ◽  
...  

HDP (hypertensive diseases in pregnancy) are one of the leading causes of maternal and fetal mortality and morbidity. BMI (body mass index) is an established risk factor for pre-eclampsia, but its role in HELLP syndrome is unknown. We therefore investigated BMI as a risk factor in the development of HELLP syndrome. At the beginning of pregnancy, BMI was measured in 1067 women with a history of HDP and 1063 controls. Diagnoses of HDP were classified according to ISSHP (International Society for the Study of Hypertension in Pregnancy) and BMI according to WHO (World Health Organization) criteria. After verification of exclusion criteria and matching for confounders, 687 women with hypertensive diseases in pregnancy and 601 controls remained for statistical evaluation by χ2 test and multiple logistic regressions. As a continuous variable, the increase in BMI was associated with an increase in the development of gestational hypertension {OR (odds ratio), 1.1 [95% CI (confidence interval) 1.062–1.197]} and pre-eclampsia [OR, 1.1 (95% CI, 1.055–1.144)]}, but not for HELLP syndrome. According to WHO definitions, overweight women (BMI ≥25 and <30 kg/m2) had a 2-fold (95% CI, 1.365–2.983) risk and obese women (BMI ≥30 kg/m2) had a 3.2-fold (95% CI, 1.7–5.909) risk of developing pre-eclampsia when compared with women of normal weight (BMI ≥15.5 and <25 kg/m2). Being overweight or having obesity had no effect on the risk of HELLP syndrome. As an increased BMI is correlated with the risk of developing pre-eclampsia but not HELLP syndrome, both diseases have a different risk profile. This finding supports that underlying physiological mechanisms in pre-eclampsia vary from those in HELLP syndrome.


2014 ◽  
Vol 28 (6) ◽  
pp. 649-653 ◽  
Author(s):  
Brigitte Leeners ◽  
Werner Rath ◽  
Sabine Kuse ◽  
Sibil Tschudin

2018 ◽  
Vol 111 (2) ◽  
pp. 62-69 ◽  
Author(s):  
Romy van de Putte ◽  
Ivo de Blaauw ◽  
Rianne Boenink ◽  
Monique H.E. Reijers ◽  
Paul M.A. Broens ◽  
...  

2017 ◽  
Vol 129 ◽  
pp. S128 ◽  
Author(s):  
Pritha Workman ◽  
Daniel Spinosa ◽  
Hui-Chun Su ◽  
Hilary Roeder

2008 ◽  
Vol 24 (4) ◽  
pp. 324-330 ◽  
Author(s):  
Carlos Antonio Negrato ◽  
Lois Jovanovic ◽  
Marcos Antonio Tambascia ◽  
Iracema de Mattos Paranhos Calderon ◽  
Bruno Geloneze ◽  
...  

Author(s):  
Shamantha Reddy ◽  
Yelena Spitzer

This chapter is a problem based learning discussion about the hypertensive diseases in pregnancy and describes incidence, risk factors, etiology, prevention and treatment of the disease. The chapter discusses risk factors for preeclampsia, the etiology and pathogenesis of preeclampsia; prevention of preeclampsia; management of preeclamptic patients; treatment of hypertension in pregnancy; eclampsia prevention and treatment; anesthetic management, including general anesthesia, of the preeclamptic patient; invasive monitoring in the preeclamptic patient; and management of HELLP syndrome. The chapter uses the case study of a 32-year-old woman at 39 weeks gestation who presents to the labor floor with headache, blurry vision, and abdominal pain for 1 day.


2010 ◽  
Vol 92 (7) ◽  
pp. e10-e11 ◽  
Author(s):  
BM Dent ◽  
A Al Samaraee ◽  
PE Coyne ◽  
C Nice ◽  
M Katory

Pregnancy is a recognised risk factor for the development of inguinal hernias due to an increase in intra-abdominal pressure. Whilst often managed conservatively until after the pregnancy, if the hernia presents acutely as a painful or tender groin lump, urgent or emergency repair may be required. Many clinicians rely heavily on clinical examination alone in order to diagnose the presence of such a hernia. In pregnancy, however, in order to prevent unnecessary surgery, the use of ultrasound has a more important role to play in reaching this diagnosis. We report a cautionary case that highlights the need for ultrasound evaluation of all painful groin lumps in pregnant women prior to considering surgery.


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