Early onset inflammatory bowel diseases and biological therapy: Results from the Sicilian Network

2017 ◽  
Vol 49 (4) ◽  
pp. e257
Author(s):  
S. Accomando ◽  
M. Citrano ◽  
S. Valenti ◽  
F. Graziano ◽  
C. Romano
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Early Onset ◽  
Biological Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel

INFLAMMATORY BOWEL DISEASES WITH VERY EARLY ONSET

2018 ◽  
Vol 97 (6) ◽  
pp. 141-146 ◽  
Author(s):  
A.E. Shchigoleva ◽  
◽  
P.V. Shumilov ◽  
А.Р. Shumilov ◽  
◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Early Onset ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Different renal manifestations associated with very early onset pediatric inflammatory bowel disease: case report and review of literature

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
A. Angeletti ◽  
S. Arrigo ◽  
A. Madeo ◽  
M. Molteni ◽  
E. Vietti ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Interstitial Nephritis ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Early Onset ◽  
Renal Involvement ◽  
Granulomatous Interstitial Nephritis ◽  
Disease Case ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Abstract Background Inflammatory bowel diseases are characterized by chronic inflammation of the gastrointestinal tract. In particular, Crohn disease and ulcerative colitis represent the two most common types of clinical manifestations. Extraintestinal manifestations of inflammatory bowel diseases represent a common complications, probably reflecting the systemic inflammation. Renal involvement is reported in 4–23% of cases. However, available data are limited to few case series and retrospective analysis, therefore the real impact of renal involvement is not well defined. Case presentation We report the case of a 10-years old male affected by very early onset unclassified-Inflammatory bowel diseases since he was 1-year old, presenting with a flare of inflammatory bowel diseases associated with acute kidney injury due to granulomatous interstitial nephritis. Of interest, at 7-year-old, he was treated for IgA nephropathy. To our knowledge, no previous reports have described a relapse of renal manifestation in inflammatory bowel diseases, characterized by two different clinical and histological phenotypes. Conclusions The link between the onset of kidney injuries with flares of intestinal inflammation suggest that nephritis maybe considered an extra-intestinal manifestation correlated with active inflammatory bowel disease. However, if granulomatous interstitial nephritis represents a cell-mediated hypersensitivity reaction than a true extraintestinal manifestation of inflammatory bowel diseases is still not clarified. We suggest as these renal manifestations here described may be interpreted as extraintestinal disorder and also considered as systemic signal of under treatment of the intestinal disease.

scholarly journals Biological therapy and surgery rates in inflammatory bowel diseases – Data analysis of almost 1000 patients from a Hungarian tertiary IBD center

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200824 ◽  
Author(s):  
Kata Szántó ◽  
Tibor Nyári ◽  
Anita Bálint ◽  
Renáta Bor ◽  
Ágnes Milassin ◽  
...  
Keyword(s):  
Data Analysis ◽  
Inflammatory Bowel Diseases ◽  
Biological Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Surgery Rates

Early onset inflammatory bowel diseases: Prevalence and clinical features

2017 ◽  
Vol 49 (4) ◽  
pp. e258
Author(s):  
M.A. Catena ◽  
V. Dipasquale ◽  
S. Gramaglia ◽  
C. Romano
Keyword(s):  
Clinical Features ◽  
Inflammatory Bowel Diseases ◽  
Early Onset ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Expression of CD44 in Monocyte and Lymphocyte Subpopulations in Patients With Inflammatory Bowel Diseases

2021 ◽  
Author(s):  
Ivana Franić ◽  
Nikolina Režić Mužinić ◽  
Anita Markotić ◽  
Piero Marin Živković ◽  
Marino Vilović ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Bowel Diseases ◽  
Disease Duration ◽  
Biological Therapy ◽  
Cd44 Expression ◽  
Bowel Diseases ◽  
Monocyte Subpopulations ◽  
Inflammatory Bowel ◽  
Lower Expression

Abstract CD44 expressed in monocytes and lymphocytes seems to play a crucial role in gastrointestinal inflammation, such as the one occurring in the context of inflammatory bowel diseases (IBD). Differentially methylated genes are distinctly expressed across monocyte subpopulations related to the state of Crohn's disease. Hence, the aim of this study was to detect CD44 expression at monocyte subpopulations, lymphocytes and granulocytes in relation to the type of IBD, therapy and disease duration. Monocyte subpopulations CD14++CD16−, CD14+CD16++ and CD14+CD16+, as well as other leukocytes, were analyzed for their CD44 expression using flow cytometry in 46 patients with IBD and 48 healthy controls. Patients with Crohn's disease treated with non-biological therapy (NBT) exhibited lower percentage of anti-inflammatory CD14+CD16++ monocytes, whereas NBT-treated patients with ulcerative colitis had lower expression of CD44 on CD14+CD44+ lymphocytes, in comparison to controls, respectively. Conversely, patients with Crohn's disease treated with biological therapy had higher percentage of CD44+ granulocytes, but lower expression of CD44 on anti-inflammatory monocytes compared to controls. Percentage of classical CD14++CD16- monocytes was lower in the <9 years of IBD duration subgroup, compared with the longer disease duration subgroup. The present study addresses the putative role of differentiation and regulation of monocyte and lymphocyte cells in tailoring IBD therapeutic regimes.

Accurate and rapid microfluidic ELISA to monitor Infliximab titers in patients with inflammatory bowel diseases

The Analyst ◽  
2022 ◽  
Author(s):  
Inês Iria ◽  
Ruben R.G. Soares ◽  
Eduardo Brás ◽  
Virginia Chu ◽  
João Gonçalves ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Chronic Inflammation ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Biological Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a term used to describe disorders that involve chronic inflammation in the gastrointestinal tract, affecting more than 6.8 million people worldwide.1 Biological therapy is used...

BIOLOGICAL THERAPY IN INFLAMMATORY BOWEL DISEASES: SAFETY PROFILE

2015 ◽  
Vol 10 (999) ◽  
pp. 1-1
Author(s):  
Antonio Di Sario ◽  
Emanuele Bendia ◽  
Laura Schiadà ◽  
Paola Sassaroli ◽  
Antonio Benedetti
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Safety Profile ◽  
Biological Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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