Liver stiffness measurement (LSM) by transient elastography (TE) predicts hepatic venous congestions and liver dysfunction but not liver fibrosis in children after Fontan procedure

2017 ◽  
Vol 49 (4) ◽  
pp. e249
Author(s):  
K. Abukasm ◽  
A. Fournier ◽  
J. Mirò ◽  
D. Dal Soglio ◽  
C. Vincent ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Dysfunction ◽  
Transient Elastography ◽  
Fontan Procedure ◽  
Liver Stiffness ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement

scholarly journals Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jamrus Pongpit ◽  
Saneerat Porntharukchareon ◽  
Piyaporn Kaewduang ◽  
Kwannapa Promson ◽  
Wasana Stitchantrakul ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Liver Fibrosis ◽  
Associated Factors ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Liver Stiffness Measurement ◽  
Nonalcoholic Fatty Liver ◽  
Stiffness Measurement ◽  
Significant Liver Fibrosis

Background. An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over 7 kPa and its associated factors in psoriatic patients. Methods. Subjects underwent TE and ultrasonography. Univariate and multivariate analysis were performed for the associated factors. Results. One hundred and sixty-eight patients were recruited. Three patients were excluded due to TE failure. Mean BMI was 24.8±4.7 kg/m2. NAFLD, metabolic syndrome, and diabetes were seen in 105 (63.6%), 83 (50.3%), and 31 (18.8%) patients. The total cumulative dose of methotrexate over 1.5 g was seen in 39 (23.6%) patients. Mean LSM was 5.3±2.9 kPa. High LSM was found in 18 (11.0%) patients. Waist circumference (OR: 1.24; 95% CI: 1.11–1.38; P=0.0002), diabetes (OR: 12.70; 95% CI: 1.84–87.70; P=0.010), and AST (OR: 1.08; 95% CI: 1.02–1.16; P=0.017) were associated with high LSM. Conclusion. 11% of psoriatic patients had significant liver fibrosis by high LSM. Waist circumference, diabetes, and AST level were the independent predictors.

scholarly journals Liver stiffness in chronic hepatitis C virus infection

2019 ◽  
Vol 57 (2) ◽  
pp. 85-98
Author(s):  
Romeo-Gabriel Mihăilă
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Esophageal Varices ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Stiffness Measurement ◽  
A Value

Abstract Introduction. The severity of liver fibrosis can be assessed noninvasively today by liver stiffness measurements. Vibration-controlled transient elastography, shear wave elastography or magnetic resonance elastography are techniques increasingly used for this purpose. Methods. This article presents the recent advances in the use of new techniques for liver fibrosis assessment in chronic hepatitis C: the correlation between liver stiffness values and liver fibrosis estimated by liver biopsies, the prognosis role of liver stiffness values, their usefulness in monitoring the treatment response, in assessing the severity of portal hypertension and in estimating the presence of esophageal varices. Scientific articles from January 2017 to January 2018 were searched in PubMed and PubMed Central databases, using the terms “liver stiffness” and “hepatitis C”. Results. The median liver stiffness values measured with different techniques are not identical, so that FibroScan thresholds cannot be used on any other elastographic machine. The higher the liver’s stiffness measurement, the higher the liver-related events in patients with chronic hepatitis C. A liver stiffness measurement over 17 kPa could be an independent predictor for the presence of esophageal varices as well as a spleen with a longitudinal span ≥ 15 cm for patients with a value of liver stiffness < 17 kPa. A progressive and persistent decrease in liver stiffness is dependent on sustained virological response achievement. The lack of liver stiffness decrease has been associated with relapsers and a low value of liver stiffness at baseline. Conclusion. Liver stiffness provides clues about the severity and evolution of liver disease.

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