Nonalcoholic fatty liver disease is associated with coronary artery calcification: A systematic review and meta-analysis

2016 ◽  
Vol 48 (12) ◽  
pp. 1410-1417 ◽  
Author(s):  
Veeravich Jaruvongvanich ◽  
Kamonkiat Wirunsawanya ◽  
Anawin Sanguankeo ◽  
Sikarin Upala
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Coronary Artery ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Coronary Artery Calcification ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver

Abstract P215: Nonalcoholic Fatty Liver Disease is Associated with Coronary Artery Calcification: a Systematic Review and Meta-analysis

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Veeravich Jaruvongvanich ◽  
Anawin Sanguankeo ◽  
Kamonkiat Wirunsawanya ◽  
Sikarin Upala
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Coronary Artery ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Surrogate Marker ◽  
Nonalcoholic Fatty Liver ◽  
Asymptomatic Individuals

Background: Whether nonalcoholic fatty liver disease (NAFLD) is related to subclinical artherosclerosis is unclear. Coronary artery calcium scanning (CAC) is the robust predictor of coronary events in the asymptomatic individuals. Several recent studies have investigated the association between NAFLD and this surrogate marker. Thus, we conducted a systematic review and meta-analysis to better characterize the association between NAFLD and CAC. Methods: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through May 2016. The inclusion criterion was the observational studies’ assessment of the association between NAFLD and CAC in adult subjects. Pooled odds ratio (OR) and 95% confidence interval (CI) from multivariate model with confounders adjustment were calculated using a random-effect, generic inverse variance method. The between-study heterogeneity of effect-size was quantified using the Q statistic and I 2 . Results: Data were extracted from 15 studies (all cross-sectional studies) involving 35,409 subjects. NAFLD is significantly associated with CAC > 0 and CAC > 100 with pooled OR of 1.41 (95% CI 1.24-1.61, P heterogeneity = 0.01, I 2 =57%) (Figure 1) and 1.24 (95% CI 1.02-1.52, P heterogeneity = 0.09, I 2 =42%). The association between NAFLD and CAC > 0 was stronger in women than men (P between sex = 0.017). Conclusions: NAFLD is also associated with coronary calcification independent of traditional risk factors, obesity and metabolic syndrome in asymptomatic individuals and this association was appeared to be stronger in women.

A systematic review and a dose–response meta-analysis of coffee dose and nonalcoholic fatty liver disease

2019 ◽  
Vol 38 (6) ◽  
pp. 2552-2557 ◽  
Author(s):  
Yong-Ping Chen ◽  
Feng-Bin Lu ◽  
Yi-Bing Hu ◽  
Lan-Man Xu ◽  
Ming-Hua Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Dose Response ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver
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