Small bowel capsule endoscopy for management of Crohn's disease: A retrospective tertiary care centre experience

2013 ◽  
Vol 45 (7) ◽  
pp. 558-561 ◽  
Author(s):  
Catherine Dussault ◽  
Corinne Gower-Rousseau ◽  
Julia Salleron ◽  
Gwénola Vernier-Massouille ◽  
Julien Branche ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

The safety and efficacy of adalimumab in patients with Crohn's disease: the experience of a single Canadian tertiary care centre

2013 ◽  
Vol 49 (3) ◽  
pp. 280-286 ◽  
Author(s):  
Anouar Teriaky ◽  
James Gregor ◽  
Brian Yan ◽  
Terry Ponich ◽  
Nilesh Chande ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Safety And Efficacy

scholarly journals P206 The prevalence of asymptomatic early sacroiliitis in Crohn’s disease patients: The single experience of an Italian tertiary care centre

2018 ◽  
Vol 12 (supplement_1) ◽  
pp. S203-S203
Author(s):  
M Di Girolamo ◽  
F Campomori ◽  
A Spinelli ◽  
A Sartini ◽  
G Sandri ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

scholarly journals Small-Bowel Capsule Endoscopy in Patients with Suspected Crohn's Disease—Diagnostic Value and Complications

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Pedro Figueiredo ◽  
Nuno Almeida ◽  
Sandra Lopes ◽  
Gabriela Duque ◽  
Paulo Freire ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Inflammatory Markers ◽  
Diagnostic Yield ◽  
Villous Atrophy ◽  
Tertiary Care ◽  
Endoscopic Findings ◽  
Capsule Retention

Background. The aim of this work was to assess the value of capsule enteroscopy in the diagnosis of patients with suspected Crohn's Disease (CD). Methods. This was a retrospective study in a single tertiary care centre involving patients undergoing capsule enteroscopy for suspected CD. Patients taking nonsteroidal anti inflammatory drugs during the thirty preceding days or with a follow-up period of less than six months were excluded. Results. Seventy eight patients were included. The endoscopic findings included mucosal breaks in 50%, ulcerated stenosis in 5%, and villous atrophy in 4%. The diagnosis of CD was established in 31 patients. The sensitivity, specificity, positive and negative predictive value of the endoscopic findings were 93%, 80%, 77%, and 94%, respectively. Capsule retention occurred in four patients (5%). The presence of ulcerated stenosis was significantly more frequent in patients with positive inflammatory markers. The diagnostic yield of capsule enteroscopy in patients with negative ileoscopy was 56%, with a diagnostic acuity of 93%. Conclusions. Small bowel capsule endoscopy is a safe and valid technique for assessing patients with suspected CD. Capsule retention is more frequent in patients with positive inflammatory markers. Patients with negative ileoscopy and suspected CD should be submitted to capsule enteroscopy.

Ustekinumab use in Crohn’s disease: a Canadian tertiary care centre experience

2017 ◽  
Vol 52 (12) ◽  
pp. 1354-1359 ◽  
Author(s):  
Astrid-Jane Greenup ◽  
Greg Rosenfeld ◽  
Brian Bressler
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

Clinicopathological and Molecular Characterisation of Crohn’s Disease-associated Small Bowel Adenocarcinomas

2019 ◽  
Vol 14 (3) ◽  
pp. 287-294 ◽  
Author(s):  
Xiaoyan Liao ◽  
Guangyuan Li ◽  
Russel McBride ◽  
Jane Houldsworth ◽  
Noam Harpaz ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Tertiary Care ◽  
Growth Patterns ◽  
Molecular Entity ◽  
Low Grade ◽  
Small Bowel Adenocarcinoma ◽  
Tertiary Care Centre ◽  
Molecular Features

Abstract Background and Aims Small bowel adenocarcinoma [SBA] is a recognised complication of Crohn’s disease [CD], but its low absolute prevalence limits opportunities for clinicopathological characterisation. Methods We compared the clinical, pathological, and molecular features of 48 SBA from patients with CD [CDSBA] and 29 SBAs from patients without CD [NSBA] who underwent treatment at our tertiary care centre between 2000 and 2018. Results Patients with CDSBA were younger than those with NSBA [mean age, 56 vs 64; p = 0.02]. Males predominated in both groups. Most CDSBA [69%] occurred in the ileum, whereas most NSBA occurred in the duodenum [38%] and jejunum [31%; p < 0.001]. Stage I tumours were more prevalent in the CDSBA [33% vs 3%; p = 0.002], although the rates of Stage IV disease and disease-specific mortality were similar in both groups. CDSBA were less likely to present a discrete mass [35% vs 93%; p < 0.001] and were more often stricturing or fistulising [75% vs 10%, respectively, p < 0.001] than NSBA. Microscopically, CDSBA were relatively heterogeneous, exhibiting at least three distinct growth patterns in 39% compared with 1% of NSBA [p = 0.01]. Low-grade tubuloglandular adenocarcinoma was the predominant pattern in 19% of CDSBA compared with 0% of NSBA [p = 0.003]. CDSBA were more frequently DNA mismatch repair proficient [90% vs 62%; p = 0.04] and exhibited profiles of frequently mutated genes similar to those of NSBA, except for IDH1 [18%] and SMAD4 [12%] mutations that occurred uniquely in CDSBA. Conclusions These observations, based on the largest single-centre series described hitherto, establish that CDSBA is a distinct clinical, pathological, and molecular entity.

scholarly journals A129 VIDEOCAPSULE ENDOSCOPY RETENTION: WHAT ARE THE RISK FACTORS?

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 112-113
Author(s):  
S Li Fraine ◽  
C Langevin ◽  
N Mahdi ◽  
M Bouin
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Abdominal Surgery ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Iron Deficient ◽  
Increased Risk ◽  
Videocapsule Endoscopy

Abstract Background The most feared complication of videocapsule endoscopy (VCE) is retention in the intestine. It is estimated to occur in 1.4% of cases but the risk factors are not well known. Aims To determine the prevalence of VCE retention at a tertiary care centre as well the associated risk factors. Methods Retrospective study between 2016 and 2019. All patients at a tertiary care centre undergoing VCE were recruited. The patients with an incomplete endoscopy report or who were unable to complete VCE were excluded. Clinical and endoscopic information was compiled from patients’ medical charts as well as the indications and results of the endoscopic procedure. VCE retention, evaluated by radiography or CT scan, was defined as persistence of the videocapsule in the gastrointestinal tract for ≥14 days or the need for an intervention for removal. Results In total, 126 patients underwent VCE (average age: 66±16, 52% female). There was 6% of patients with Crohn’s disease, and 40% of patients had a previous abdominal surgery. The indications for endoscopy were: iron deficient anemia (48%), gastrointestinal bleeding (32%), suspicion/follow up of IBD (10%), and other (11%). The VCE findings (n=146) were: angiodysplasia (30%), inflammation (30%), normal (20%), polyp (5%), and other (15%). 77% of results were not previously found by conventional endoscopy or imaging. The prevalence of VCE retention was 1.6%. The patient risk factors for retention were Crohn’s disease (OR 19.67; 95CI 1.09–354.11; p<0.05) and corticosteroid use in the previous 2 weeks (OR 19.67; 95CI 1.09–354.11; p<0.05). There was no risk of retention associated with ulcerative colitis, sex, abdominal surgery, or opioid use. The finding of stenosis on VCE was associated with an increased risk of retention (OR 123; 95% CI 4.11-3683.43; p<0.01). Conclusions VCE retention remains a rare complication. There is increased risk of retention in patients with known Crohn’s disease or recent use of corticosteroids. Funding Agencies None

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