Performance and utility of transient elastography and noninvasive markers of liver fibrosis in primary biliary cirrhosis

2011 ◽  
Author(s):  
Annarosa Floreani ◽  
Nora Cazzagon ◽  
Diego Martines ◽  
Luisa Cavalletto ◽  
Vincenzo Baldo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Transient Elastography ◽  
Biliary Cirrhosis ◽  
Noninvasive Markers

scholarly journals Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis

2018 ◽  
Vol 75 (4) ◽  
pp. 374-379
Author(s):  
Tamara Milovanovic ◽  
Ana Copertino ◽  
Ivan Boricic ◽  
Biljana Milicic ◽  
Aleksandra Pavlovic-Markovic ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Liver Biopsy ◽  
Transient Elastography ◽  
Fibrosis Stage ◽  
Biliary Cirrhosis ◽  
Noninvasive Methods ◽  
Significant Difference ◽  
Apri Score ◽  
Noninvasive Markers

Backgrund/Aim. In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p < 0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures.

OC.11.4 PERFORMANCE OF TRANSIENT ELASTOGRAPHY AND NON INVASIVE MARKERS OF LIVER FIBROSIS IN PRIMARY BILIARY CIRRHOSIS

2010 ◽  
Vol 42 ◽  
pp. S96
Author(s):  
N. Cazzagon ◽  
L. Chemello ◽  
D. Martines ◽  
L. Cavalletto ◽  
V. Baldo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Transient Elastography ◽  
Biliary Cirrhosis ◽  
Non Invasive

F.N.2 PERFORMANCE OF TRANSIENT ELASTOGRAPHY AND NON INVASIVE MARKERS OF LIVER FIBROSIS IN PRIMARY BILIARY CIRRHOSIS

2010 ◽  
Vol 42 ◽  
pp. S33
Author(s):  
N. Cazzagon ◽  
L. Chemello ◽  
D. Martines ◽  
L. Cavalletto ◽  
V. Baldo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Transient Elastography ◽  
Biliary Cirrhosis ◽  
Non Invasive

393 PERFORMANCE OF TRANSIENT ELASTOGRAPHY AND NON INVASIVE MARKERS OF LIVER FIBROSIS IN PRIMARY BILIARY CIRRHOSIS

2010 ◽  
Vol 52 ◽  
pp. S161-S162
Author(s):  
N. Cazzagon ◽  
L. Chemello ◽  
D. Martines ◽  
L. Cavalletto ◽  
V. Baldo ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Transient Elastography ◽  
Biliary Cirrhosis ◽  
Non Invasive

scholarly journals Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay

Hepatology ◽  
2008 ◽  
Vol 48 (5) ◽  
pp. 1549-1557 ◽  
Author(s):  
Marlyn J. Mayo ◽  
Julie Parkes ◽  
Beverley Adams-Huet ◽  
Burton Combes ◽  
A. S. Mills ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Clinical Outcomes ◽  
Biliary Cirrhosis

Biochemical markers of liver fibrosis and lymphocytic piecemeal necrosis in UDCA-treated patients with primary biliary cirrhosis

2004 ◽  
Vol 24 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Christophe Corpechot ◽  
Armelle Poujol-Robert ◽  
Dominique Wendum ◽  
Marie Galotte ◽  
Yves Chretien ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Biochemical Markers ◽  
Biliary Cirrhosis ◽  
Piecemeal Necrosis

Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis

Hepatology ◽  
2012 ◽  
Vol 56 (1) ◽  
pp. 198-208 ◽  
Author(s):  
Christophe Corpechot ◽  
Fabrice Carrat ◽  
Armelle Poujol-Robert ◽  
Farid Gaouar ◽  
Dominique Wendum ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Fibrosis Progression

scholarly journals The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis

Hepatology ◽  
2000 ◽  
Vol 32 (6) ◽  
pp. 1196-1199 ◽  
Author(s):  
Christophe Corpechot ◽  
Fabrice Carrat ◽  
Anne-Marie Bonnand ◽  
Renée Eugénie Poupon ◽  
Raoul Poupon
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Ursodeoxycholic Acid ◽  
Biliary Cirrhosis ◽  
Acid Therapy ◽  
Fibrosis Progression
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