Racecadotril directly induces ion absorption under basal condition and inhibits rotavirus chloride secretion in human enterocytes

2008 ◽  
Vol 40 (10) ◽  
pp. A74-A75
Author(s):  
C. Armellino ◽  
V. Buccigrossi ◽  
M. Penza ◽  
I. Bracale ◽  
M. Oliva ◽  
...  
Keyword(s):  
Chloride Secretion ◽  
Ion Absorption

scholarly journals Ion Absorption in Atriplex Leaf Tissue III. Site of Metabolic Control of Light-Dependent Chloride Secretion to Epidermal Bladders

1970 ◽  
Vol 23 (1) ◽  
pp. 17 ◽  
Author(s):  
U Lüttge ◽  
CB Osmond
Keyword(s):  
Metabolic Control ◽  
Active Transport ◽  
Chloride Transport ◽  
Leaf Tissue ◽  
Chloride Secretion ◽  
Ion Absorption

The nature and location of the light-stimulated active transport of chloride to the epidermal bladders of A. 8pongio8a leaves was examined. Chloride transport to the bladder vacuole was found to have properties similar to those for light-dependent

Endothelin stimulates chloride secretion across canine tracheal epithelium

1991 ◽  
Vol 261 (2) ◽  
pp. L188-L194 ◽  
Author(s):  
P. I. Plews ◽  
Z. A. Abdel-Malek ◽  
C. A. Doupnik ◽  
G. D. Leikauf
Keyword(s):  
Epithelial Cells ◽  
Short Circuit ◽  
Second Messengers ◽  
Short Circuit Current ◽  
Chloride Secretion ◽  
Tracheal Epithelium ◽  
Membrane Phospholipids ◽  
Cl Secretion ◽  
Tracheal Epithelial Cells ◽  
Tracheal Epithelial

The endothelins (ET) are a group of isopeptides produced by a number of cells, including canine tracheal epithelial cells. Because these compounds are endogenous peptides that may activate eicosanoid metabolism, we investigated the effects of ET on Cl secretion in canine tracheal epithelium. Endothelin 1 (ET-1) was found to produce a dose-dependent change in short-circuit current (Isc) that increased slowly and reached a maximal value within 10-15 min. When isopeptides of ET were compared, 300 nM ET-1 and ET-2 produced comparable maximal increases in Isc, whereas ET-3 produced smaller changes in Isc (half-maximal concentrations of 2.2, 7.2, and 10.4 nM, respectively). Ionic substitution of Cl with nontransported anions, iodide and gluconate, reduced ET-1-induced changes in Isc. Furthermore, the response was inhibited by the NaCl cotransport inhibitor, furosemide. In paired tissues, ET-1 significantly increased mucosal net 36Cl flux without significant effect on 22Na flux. The increase in Isc induced by ET was diminished by pretreatment with indomethacin. The second messengers mediating the increase in Isc were investigated in cultured canine tracheal epithelial cells. ET-1 stimulated the release of [3H]arachidonate from membrane phospholipids, increased intracellular Ca2+ (occasionally producing oscillations), and increased adenosine 3',5'-cyclic monophosphate accumulation. The latter was diminished by indomethacin. Thus ET is a potent agonist of Cl secretion (with the isopeptides having the following potency: ET-1 greater than or equal to ET-2 greater than ET-3) and acts, in part, through a cyclooxygenase-dependent mechanism.

Chloride secretion and conductance of teleost opercular membrane: effects of prolactin

1982 ◽  
Vol 242 (3) ◽  
pp. R380-R389 ◽  
Author(s):  
J. K. Foskett ◽  
T. E. Machen ◽  
H. A. Bern
Keyword(s):  
Active Transport ◽  
Short Circuit ◽  
Chloride Secretion ◽  
Alternative Interpretation ◽  
Chloride Cells ◽  
Dependent Manner ◽  
Transport Pathway ◽  
Accurate Analysis ◽  
Equivalent Circuit Analysis ◽  
Fish Yield

Effects of prolactin on transport properties of opercular membranes from seawater-adapted tilapia, Sarotherodon mossambicus, have been examined. These membranes are high conductance (average Gt approximately 4 mS.cm-2) tissues with short-circuit currents (I) equal to net chloride secretion. Despite high Gt, nonlinear current-voltage relationships suggest that opercular membranes cannot be classified as "leaky" tissues. Variability among membranes is reflected in a linear relationship between I and Gt with a slope equal to 26 mV and the zero-current Gt intercept equal to 0.45 mS.cm-2. Prolactin injections decrease I and Gt in a dose-dependent manner. Phosphodiesterase inhibition, without effect on I in untreated fish, often partially reverses these prolactin effects. Gt-I data from prolactin-treated fish yield a slope of 18 mV and a Gt intercept of 0.10 mS.cm-2. The effects of prolactin are discussed in terms of conventional equivalent circuit analysis. Discrepancies between predictions based on this model and the actual data indicate that an alternative interpretation, based on a heterogeneous cell population, is more accurate. Analysis of this circuit suggests that the ratio of paracellular to active transport pathway conductances associated with chloride cells is constant and that differences in Gt and I are due to parallel changes in these conductances. Prolactin may effectively "remove" chloride cells from these membranes as well as inhibit (reversible by elevated cellular cAMP levels) active transport pathway conductance of remaining cells.

Ion absorption by leaves

1967 ◽  
Vol 54 (14) ◽  
pp. 373-373 ◽  
Author(s):  
S. Kannan ◽  
S. H. Wittwer
Keyword(s):  
Ion Absorption

scholarly journals Ion Absorption by Shoot Tissue: Technique and First Findings with Excised Leaf Tissue of Corn

1964 ◽  
Vol 39 (3) ◽  
pp. 338-341 ◽  
Author(s):  
Richard C. Smith ◽  
Emanuel Epstein
Keyword(s):  
Leaf Tissue ◽  
Shoot Tissue ◽  
Ion Absorption
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