HFE, TGF-BETA1 and squamous cell carcinoma antigen-1 polymorphisms and liver disease stage in chronic HCV infection

2007 ◽  
Vol 39 (3) ◽  
pp. A27
Author(s):  
C. Turato ◽  
M.G. Ruvoletto ◽  
A. Biasiolo ◽  
S. Quarta ◽  
N. Tono ◽  
...  
2009 ◽  
Vol 41 (3) ◽  
pp. 212-216 ◽  
Author(s):  
C. Turato ◽  
M.G. Ruvoletto ◽  
A. Biasiolo ◽  
S. Quarta ◽  
N. Tono ◽  
...  

2013 ◽  
Vol 85 (6) ◽  
pp. 1005-1008 ◽  
Author(s):  
Alessandra Biasiolo ◽  
Natascia Tono ◽  
Martina Zaninotto ◽  
Carlo Merkel ◽  
Giorgio Fassina ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Marco Cagnin ◽  
Alessandra Biasiolo ◽  
Andrea Martini ◽  
Mariagrazia Ruvoletto ◽  
Santina Quarta ◽  
...  

AbstractComplications of chronic liver diseases – particularly hepatocellular carcinoma (HCC) – are a major cause of mortality worldwide. Several studies have shown that high or increasing levels of serum Squamous Cell Carcinoma Antigen-Immunoglobulin M complex (SCCA-IgM) are associated with development of HCC in patients with advanced liver disease and worse survival in patients with liver cancer. The aim of the present study was to assess, in patients with advanced liver disease, differences in long-term clinical outcomes in relation to baseline levels of serum SCCA-IgM. Ninety one consecutive outpatients with liver cirrhosis of different etiologies, without hepatocellular carcinoma at presentation, were enrolled from April 2007 to October 2012 in a prospective study. For a median time of 127 months, patients were bi-annually re-evaluated. SCCA-IgM complex levels were determined with a validated enzyme-linked immunosorbent assay. The results provided evidence that serum SCCA-IgM is a predictor of overall survival. The best cut-off to discriminate both HCC-free and overall survival rates was 120 AU/mL. Patients with baseline values higher than this threshold showed a substantial increase in both HCC incidence rate and all-cause mortality rate. In conclusion, a single measurement of serum SCCA-IgM helps to identify those patients with liver cirrhosis with increased risks of HCC development and mortality.


2007 ◽  
Vol 25 (2) ◽  
pp. 187-189 ◽  
Author(s):  
Katsunori Kagohashi ◽  
Hiroaki Satoh ◽  
Hiroichi Ishikawa ◽  
Morio Ohtsuka ◽  
Kiyohisa Sekizawa

FEBS Letters ◽  
1995 ◽  
Vol 359 (1) ◽  
pp. 78-80 ◽  
Author(s):  
Atsushi Takeda ◽  
Takako Yamamoto ◽  
Yoshiko Nakamura ◽  
Tadahito Takahashi ◽  
Toshihiko Hibino

2012 ◽  
Vol 26 (5) ◽  
pp. 365-370 ◽  
Author(s):  
Mikio Suzuki ◽  
Zeyi Deng ◽  
Masahiro Hasegawa ◽  
Takayuki Uehara ◽  
Asanori Kiyuna ◽  
...  

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