Expression of estrogen receptor isoforms in liver dendritic cells

2007 ◽  
Vol 39 (3) ◽  
pp. A16-A17
Author(s):  
A. Castellaneta ◽  
N. De Tullio ◽  
F. Gagliardi ◽  
M. Margiotta ◽  
S. Tanzi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Estrogen Receptor ◽  
Receptor Isoforms ◽  
Estrogen Receptor Isoforms

Estrogen Regulation of Adipose Tissue Functions: Involvement of Estrogen Receptor Isoforms

2008 ◽  
Vol 8 (1) ◽  
pp. 52-60 ◽  
Author(s):  
V. Pallottini ◽  
P. Bulzomi ◽  
P. Galluzzo ◽  
C. Martini ◽  
M. Marino
Keyword(s):  
Estrogen Receptor ◽  
Adipose Tissue ◽  
Estrogen Regulation ◽  
Receptor Isoforms ◽  
Estrogen Receptor Isoforms

scholarly journals Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ERα and ERβ) in rat kidney proximal tubule

2015 ◽  
Vol 308 (6) ◽  
pp. F522-F534 ◽  
Author(s):  
Dara Burris ◽  
Rose Webster ◽  
Sulaiman Sheriff ◽  
Rashma Faroqui ◽  
Moshe Levi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Proximal Tubule ◽  
Rat Kidney ◽  
Ovariectomized Rats ◽  
Kidney Cortex ◽  
Kidney Proximal Tubule ◽  
Receptor Isoforms ◽  
Ovx Rats ◽  
Estrogen Receptor Isoforms

We have previously demonstrated that estrogen (E2) downregulates phosphate transporter NaPi-IIa and causes phosphaturia and hypophosphatemia in ovariectomized rats. In the present study, we examined whether E2directly targets NaPi-IIa in the proximal tubule (PT) and studied the respective roles of estrogen receptor isoforms (ERα and ERβ) in the downregulation of NaPi-IIa using both in vivo and an in vitro expression systems. We found that estrogen specifically downregulates NaPi-IIa but not NaPi-IIc or Pit2 in the kidney cortex. Proximal tubules incubated in a “shake” suspension with E2for 24 h exhibited a dose-dependent decrease in NaPi-IIa protein abundance. Results from OVX rats treated with specific agonists for either ERα [4,4′,4″;-(4-propyl-[1 H]-pyrazole-1,3,5-triyl) trisphenol, PPT] or ERβ [4,4′,4″-(4-propyl-[1 H]-pyrazole-1,3,5-triyl) trisphenol, DPN] or both (PPT + DPN), indicated that only the latter caused a sharp downregulation of NaPi-IIa, along with significant phosphaturia and hypophosphatemia. Lastly, heterologous expression studies demonstrated that estrogen downregulated NaPi-IIa only in U20S cells expressing both ERα and ERβ, but not in cells expressing either receptor alone. In conclusion, these studies demonstrate that rat PT cells express both ERα and ERβ and that E2induces phosphaturia by directly and specifically targeting NaPi-IIa in the PT cells. This effect is mediated via a mechanism involving coactivation of both ERα and ERβ, which likely form a functional heterodimer complex in the rat kidney proximal tubule.

scholarly journals Selective Agonists of Estrogen Receptor Isoforms

2006 ◽  
Vol 26 (10) ◽  
pp. 2192-2199 ◽  
Author(s):  
Chiara Bolego ◽  
Elisabetta Vegeto ◽  
Christian Pinna ◽  
Adriana Maggi ◽  
Andrea Cignarella
Keyword(s):  
Estrogen Receptor ◽  
Receptor Isoforms ◽  
Selective Agonists ◽  
Estrogen Receptor Isoforms

scholarly journals Estrogenic Effects of Fluorotelomer Alcohols for Human Estrogen Receptor Isoforms α and β in Vitro

2007 ◽  
Vol 30 (7) ◽  
pp. 1358-1359 ◽  
Author(s):  
Hiroshi Ishibashi ◽  
Haruna Ishida ◽  
Munekazu Matsuoka ◽  
Nobuaki Tominaga ◽  
Koji Arizono
Keyword(s):  
Estrogen Receptor ◽  
Estrogenic Effects ◽  
Receptor Isoforms ◽  
Fluorotelomer Alcohols ◽  
Human Estrogen Receptor ◽  
Estrogen Receptor Isoforms
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