Islet Neogenesis Associated Protein (INGAP) induces the differentiation of an adult human pancreatic ductal cell line into insulin-expressing cells through stepwise activation of key transcription factors for embryonic beta cell development

2015 ◽  
Vol 90 (4-5) ◽  
pp. 77-90 ◽  
Author(s):  
Béatrice Assouline-Thomas ◽  
Daniel Ellis ◽  
Maria Petropavlovskaia ◽  
Julia Makhlin ◽  
Jieping Ding ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Beta Cell ◽  
Cell Line ◽  
Cell Development ◽  
Islet Neogenesis ◽  
Adult Human ◽  
Ductal Cell ◽  
Beta Cell Development ◽  
Pancreatic Ductal Cell

Mesenchymal Stem Cells Derived From Human Exocrine Pancreas Express Transcription Factors Implicated in Beta-Cell Development

Pancreas ◽  
2008 ◽  
Vol 37 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Reto M. Baertschiger ◽  
Domenico Bosco ◽  
Philippe Morel ◽  
Veronique Serre-Beinier ◽  
Thierry Berney ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Transcription Factors ◽  
Beta Cell ◽  
Exocrine Pancreas ◽  
Cell Development ◽  
Beta Cell Development

scholarly journals Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas

Diabetologia ◽  
2009 ◽  
Vol 53 (4) ◽  
pp. 699-711 ◽  
Author(s):  
M. Al-Masri ◽  
M. Krishnamurthy ◽  
J. Li ◽  
G. F. Fellows ◽  
H. H. Dong ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Development ◽  
Fetal Pancreas ◽  
Forkhead Box ◽  
Human Fetal Pancreas ◽  
Beta Cell Development

scholarly journals The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice

Diabetologia ◽  
2016 ◽  
Vol 59 (5) ◽  
pp. 1007-1011 ◽  
Author(s):  
Yusuf Ali ◽  
Juan Diez ◽  
Lars Selander ◽  
Xiaofeng Zheng ◽  
Helena Edlund ◽  
...  
Keyword(s):  
Beta Cell ◽  
Anterior Chamber ◽  
Cell Development ◽  
Beta Cell Development ◽  
Transplantation Site

scholarly journals The stress of starvation: glucocorticoid restraint of beta cell development

Diabetologia ◽  
2010 ◽  
Vol 54 (2) ◽  
pp. 223-226 ◽  
Author(s):  
L. C. Matthews ◽  
N. A. Hanley
Keyword(s):  
Beta Cell ◽  
Cell Development ◽  
Beta Cell Development

scholarly journals Impairment of Rat Fetal Beta-Cell Development by Maternal Exposure to Dexamethasone during Different Time-Windows

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e25576 ◽  
Author(s):  
Olivier Dumortier ◽  
Nicolas Theys ◽  
Marie-Thérèse Ahn ◽  
Claude Remacle ◽  
Brigitte Reusens
Keyword(s):  
Beta Cell ◽  
Time Windows ◽  
Cell Development ◽  
Maternal Exposure ◽  
Beta Cell Development

scholarly journals PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits

2021 ◽  
Author(s):  
kevin Saitoski ◽  
Maria Ryaboshapkina ◽  
Ghaith Hamza ◽  
Andrew F Jarnuczak ◽  
claire berthault ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Beta Cell ◽  
Pancreatic Islets ◽  
Cell Line ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Pancreatic Beta Cell ◽  
Loss Of Function ◽  
Beta Cell Line ◽  
Gain And Loss

Aims/hypothesis: Proprotein convertase subtilisin/kexin 9 (PCSK9) is involved in the degradation of LDLR. However, PCSK9 can target other proteins in a cell-type specific manner. While PCSK9 has been detected in pancreatic islets, its expression in insulin-producing pancreatic beta cells is debated. Herein, we studied PCSK9 expression, regulation and function in the human pancreatic beta cell line EndoC-βH1. Methods: We assessed PCSK9 expression in mouse and human pancreatic islets, and in the pancreatic beta cell line EndoC-βH1. We also studied PCSK9 regulation by cholesterol, lipoproteins, Mevastatin, and by SREBPs transcription factors. To evaluate PCSK9 function in pancreatic beta cells, we performed PCSK9 gain-and loss-of-function experiments in EndoC-βH1 using siPCSK9 or recombinant PCSK9 treatments, respectively. Results: We demonstrate that PCSK9 is expressed and secreted by pancreatic beta cells. In EndoC-βH1 cells, PCSK9 expression is regulated by cholesterol and by SREBPs transcription factors. Importantly, PCSK9 knockdown results in multiple transcriptome, proteome and secretome deregulations and impaired insulin secretion. By gain- and loss-of- function experiments, we observed that PCSK9 regulates the expression levels of LDLR and VLDLR through an extracellular mechanism while CD36, PD-L1 and HLA-ABC are regulated through an intracellular mechanism. Conclusions/interpretation: Collectively, these results highlight PCSK9 as an important regulator of CD36, PD-L1 and HLA-ABC cell surface expression in pancreatic beta cells. Data availability: RNA-seq data have been deposited to GEO database with accession number GSE182016. Mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the following identifiers: PXD027921, PXD027911 and PXD027913.

scholarly journals A synopsis of factors regulating beta cell development and beta cell mass

2016 ◽  
Vol 73 (19) ◽  
pp. 3623-3637 ◽  
Author(s):  
Krishna Prasadan ◽  
Chiyo Shiota ◽  
Xiao Xiangwei ◽  
David Ricks ◽  
Joseph Fusco ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Cell Development ◽  
Beta Cell Development

scholarly journals Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice

Diabetologia ◽  
2015 ◽  
Vol 59 (1) ◽  
pp. 139-150 ◽  
Author(s):  
Vivian Anastasiou ◽  
Elpiniki Ninou ◽  
Dimitra Alexopoulou ◽  
Julia Stertmann ◽  
Andreas Müller ◽  
...  
Keyword(s):  
Beta Cell ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Cell Development ◽  
Beta Cell Development ◽  
Aldehyde Dehydrogenase Activity
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