scholarly journals The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis

2009 ◽  
Vol 77 (5) ◽  
pp. 492-504 ◽  
Author(s):  
Morgan Salmon ◽  
Zendra E. Zehner
Keyword(s):  
Transcriptional Repressor ◽  
Down Regulation ◽  
Vimentin Gene

Down-regulation of vimentin gene expression during myogenesis is controlled by a 5′-flanking sequence

Gene ◽  
1989 ◽  
Vol 78 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Christina M. Sax ◽  
Francis X. Farrell ◽  
Zendra E. Zehner
Keyword(s):  
Gene Expression ◽  
Flanking Sequence ◽  
Down Regulation ◽  
Vimentin Gene

scholarly journals Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua

2016 ◽  
Vol 113 (38) ◽  
pp. 10583-10588 ◽  
Author(s):  
Liu Yang ◽  
Sayantanee Paul ◽  
Kenneth G. Trieu ◽  
Lucas G. Dent ◽  
Francesca Froldi ◽  
...  
Keyword(s):  
Transcriptional Repressor ◽  
Adaptor Protein ◽  
Down Regulation ◽  
Organ Growth ◽  
Extracellular Signal Regulated Kinase ◽  
Multiple Organs ◽  
Tissue Patterning ◽  
Extracellular Signal ◽  
Control Organ ◽  
The Brain

The transcriptional repressor Capicua (Cic) controls tissue patterning and restricts organ growth, and has been recently implicated in several cancers. Cic has emerged as a primary sensor of signaling downstream of the receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase (ERK) pathway, but how Cic activity is regulated in different cellular contexts remains poorly understood. We found that the kinase Minibrain (Mnb, ortholog of mammalian DYRK1A), acting through the adaptor protein Wings apart (Wap), physically interacts with and phosphorylates the Cic protein. Mnb and Wap inhibit Cic function by limiting its transcriptional repressor activity. Down-regulation of Cic by Mnb/Wap is necessary for promoting the growth of multiple organs, including the wings, eyes, and the brain, and for proper tissue patterning in the wing. We have thus uncovered a previously unknown mechanism of down-regulation of Cic activity by Mnb and Wap, which operates independently from the ERK-mediated control of Cic. Therefore, Cic functions as an integrator of upstream signals that are essential for tissue patterning and organ growth. Finally, because DYRK1A and CIC exhibit, respectively, prooncogenic vs. tumor suppressor activities in human oligodendroglioma, our results raise the possibility that DYRK1A may also down-regulate CIC in human cells.

scholarly journals Wnt-mediated Down-regulation of Sp1 Target Genes by a Transcriptional Repressor Sp5

2006 ◽  
Vol 282 (2) ◽  
pp. 1225-1237 ◽  
Author(s):  
Naoko Fujimura ◽  
Tomas Vacik ◽  
Ondrej Machon ◽  
Cestmir Vlcek ◽  
Simone Scalabrin ◽  
...  
Keyword(s):  
Target Genes ◽  
Transcriptional Repressor ◽  
Down Regulation
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