scholarly journals Data generated from three quantitative mass spectral methods for the analysis of trivalent influenza vaccine antigens are compared

Data in Brief ◽  
2016 ◽  
Vol 9 ◽  
pp. 169-176
Author(s):  
Daryl G.S. Smith ◽  
Geneviève Gingras ◽  
Yves Aubin ◽  
Terry D. Cyr
Keyword(s):  
Influenza Vaccine ◽  
Spectral Methods ◽  
Mass Spectral ◽  
Trivalent Influenza Vaccine ◽  
Vaccine Antigens

An Elegant Synthetic Route to 3-Cyano-5,6-dihydro-2-ethoxy-4-phenyl-pyrido[2,3-a]carbazoles

2004 ◽  
Vol 59 (1) ◽  
pp. 106-108 ◽  
Author(s):  
Isravel A. Danish ◽  
Karnam J. R. Prasad
Keyword(s):  
Elemental Analysis ◽  
Spectral Methods ◽  
Title Compound ◽  
Sodium Hydride ◽  
Synthetic Route ◽  
Mass Spectral ◽  
Plausible Mechanism

Abstract 2-Benzylidene-1-oxo-1,2,3,4-tetrahydrocarbazoles (1a - e) obtained from the corresponding 1- oxo-1,2,3,4-tetrahydrocarbazoles on reaction with malononitrile in dry benzene with sodium hydride afforded 3-cyano-5,6-dihydro-2-ethoxy-4-phenyl-pyrido[2,3-a]carbazoles (2a - e) in good yields. A plausible mechanism for the formation of the title compound has been proposed and all the compounds were characterised by IR, NMR, mass spectral methods and elemental analysis.

Immunogenicity of trivalent influenza vaccine in children with acute lymphoblastic leukemia during maintenance therapy

2010 ◽  
Vol 54 (5) ◽  
pp. 716-720 ◽  
Author(s):  
Elham Shahgholi ◽  
Mohammad Ali Ehsani ◽  
Payman Salamati ◽  
Alipasha Maysamie ◽  
Kambiz Sotoudeh ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Influenza Vaccine ◽  
Maintenance Therapy ◽  
Lymphoblastic Leukemia ◽  
Trivalent Influenza Vaccine

Biosynthetic studies on gliotoxin using stable isotopes and mass spectral methods

1968 ◽  
Vol 90 (4) ◽  
pp. 1038-1041 ◽  
Author(s):  
Ajay K. Bose ◽  
K. Ganesh. Das ◽  
Phillip T. Funke ◽  
Irene. Kugajevsky ◽  
O. P. Shukla ◽  
...  
Keyword(s):  
Stable Isotopes ◽  
Spectral Methods ◽  
Mass Spectral ◽  
Biosynthetic Studies

Influenza Vaccination in Adults with Asthma: Safety of an Inactivated Trivalent Influenza Vaccine

2007 ◽  
Vol 44 (10) ◽  
pp. 817-822 ◽  
Author(s):  
T. Kmiecik ◽  
Sabine Arnoux ◽  
Aleksandra Kobryn ◽  
Pawel Gorski
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Trivalent Influenza Vaccine

scholarly journals Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans

2019 ◽  
Vol 94 (4) ◽  
Author(s):  
Pramila Rijal ◽  
Bei Bei Wang ◽  
Tiong Kit Tan ◽  
Lisa Schimanski ◽  
Philipp Janesch ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Influenza Vaccine ◽  
Time Window ◽  
Wide Spectrum ◽  
Influenza Viruses ◽  
Human Mabs ◽  
Human Antibodies ◽  
Trivalent Influenza Vaccine ◽  
H5n1 Influenza ◽  
H7n9 Infection

ABSTRACT The majority of antibodies induced by influenza neuraminidase (NA), like those against hemagglutinin (HA), are relatively specific to viruses isolated within a limited time window, as seen in serological studies and the analysis of many murine monoclonal antibodies (MAbs). We report three broadly reactive human MAbs targeting N1 NA. Two were isolated from a young adult vaccinated with trivalent influenza vaccine (TIV), which inhibited N1 NA from viruses isolated from humans over a period of a hundred years. The third antibody, isolated from a child with acute mild H7N9 infection, inhibited both group 1 N1 and group 2 N9 NAs. In addition, the antibodies cross-inhibited the N1 NAs of highly pathogenic avian H5N1 influenza viruses. These antibodies are protective in prophylaxis against seasonal H1N1 viruses in mice. This study demonstrates that human antibodies to N1 NA with exceptional cross-reactivity can be recalled by vaccination and highlights the importance of standardizing the NA antigen in seasonal vaccines to offer optimal protection. IMPORTANCE Antibodies to the influenza virus NA can provide protection against influenza disease. Analysis of human antibodies to NA lags behind that of antibodies to HA. We show that human monoclonal antibodies against NA induced by vaccination and infection can be very broadly reactive, with the ability to inhibit a wide spectrum of N1 NAs on viruses isolated between 1918 and 2018. This suggests that antibodies to NA may be a useful therapy and that the efficacy of influenza vaccines could be enhanced by ensuring the appropriate content of NA antigen.

scholarly journals Vaccine effectiveness for influenza in the elderly in welfare nursing homes during an influenza A (H3N2) epidemic

2000 ◽  
Vol 125 (2) ◽  
pp. 393-397 ◽  
Author(s):  
Y. DEGUCHI ◽  
Y. TAKASUGI ◽  
K. NISHIMURA
Keyword(s):  
Nursing Homes ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Hospital Admissions ◽  
Influenza Virus Infection ◽  
Severe Infection ◽  
The Elderly ◽  
Trivalent Influenza Vaccine ◽  
Homes For The Elderly ◽  
Vaccine Effect

Influenza vaccine effect on the occurrence and severity of influenza virus infection in a population residing in nursing homes for the elderly was studied as a cohort study during an influenza A (H3N2) epidemic in Japan. Of 22462 individuals living in 301 welfare nursing homes, 10739 voluntarily received inactivated, sub-unit trivalent influenza vaccine in a programme supported by the Osaka Prefectural Government. There were statistically significantly fewer cases of influenza, hospital admissions due to severe infection, and deaths due to influenza in the vaccinated cohort compared to the unvaccinated controls. No serious adverse reactions to vaccination were recorded. Thus influenza vaccination is effective for preventing influenza disease in persons aged 65 years and over, and should be an integral part of the care of this population residing in nursing homes.

scholarly journals Cost-effectiveness of introducing an MF59-adjuvanted trivalent influenza vaccine for older adults in Argentina

Vaccine ◽  
2020 ◽  
Vol 38 (20) ◽  
pp. 3682-3689 ◽  
Author(s):  
Van Hung Nguyen ◽  
Carla Vizzotti ◽  
Analia Uruena ◽  
Norberto Giglio ◽  
Cecilia Magneres ◽  
...  
Keyword(s):  
Older Adults ◽  
Cost Effectiveness ◽  
Influenza Vaccine ◽  
Trivalent Influenza Vaccine
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