scholarly journals Diffusion tensor microscopy data (15.6 μm in-plane) of white matter tracts in the human, pig, and rat spinal cord with corresponding tissue histology

Data in Brief ◽  
2016 ◽  
Vol 9 ◽  
pp. 271-274 ◽  
Author(s):  
Jeremy J. Flint ◽  
Brian Hansen ◽  
Stephen J. Blackband
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Diffusion Tensor ◽  
Rat Spinal Cord ◽  
White Matter Tracts ◽  
Tissue Histology ◽  
Microscopy Data

scholarly journals In vivo DTI evaluation of white matter tracts in rat spinal cord

2006 ◽  
Vol 24 (1) ◽  
pp. 231-234 ◽  
Author(s):  
Jayaroop Gullapalli ◽  
Jaroslaw Krejza ◽  
Eric D. Schwartz
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Rat Spinal Cord ◽  
White Matter Tracts

scholarly journals Longitudinal changes in DTI parameters of specific spinal white matter tracts correlate with behavior following spinal cord injury in monkeys

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Arabinda Mishra ◽  
Feng Wang ◽  
Li Min Chen ◽  
John C. Gore
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Injuries ◽  
Diffusion Tensor ◽  
Cervical Spinal Cord ◽  
Human Subjects ◽  
Realistic Model ◽  
White Matter Tracts ◽  
Injured Side ◽  
Cord Injury

Abstract This study aims to evaluate how parameters derived from diffusion tensor imaging reflect axonal disruption and demyelination in specific white matter tracts within the spinal cord of squirrel monkeys following traumatic injuries, and their relationships to function and behavior. After a unilateral section of the dorsal white matter tract of the cervical spinal cord, we found that both lesioned dorsal and intact lateral tracts on the lesion side exhibited prominent disruptions in fiber orientation, integrity and myelination. The degrees of pathological changes were significantly more severe in segments below the lesion than above. The lateral tract on the opposite (non-injured) side was minimally affected by the injury. Over time, RD, FA, and AD values of the dorsal and lateral tracts on the injured side closely tracked measurements of the behavioral recovery. This unilateral section of the dorsal spinal tract provides a realistic model in which axonal disruption and demyelination occur together in the cord. Our data show that specific tract and segmental FA and RD values are sensitive to the effects of injury and reflect specific behavioral changes, indicating their potential as relevant indicators of recovery or for assessing treatment outcomes. These observations have translational value for guiding future studies of human subjects with spinal cord injuries.

scholarly journals MultiexponentialT2, magnetization transfer, and quantitative histology in white matter tracts of rat spinal cord

2010 ◽  
Vol 63 (4) ◽  
pp. 902-909 ◽  
Author(s):  
Adrienne N. Dula ◽  
Daniel F. Gochberg ◽  
Holly L. Valentine ◽  
William M. Valentine ◽  
Mark D. Does
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Magnetization Transfer ◽  
Rat Spinal Cord ◽  
White Matter Tracts ◽  
Quantitative Histology

Spatial correspondence of spinal cord white matter tracts using diffusion tensor imaging, fibre tractography, and atlas-based segmentation

2021 ◽  
Vol 63 (3) ◽  
pp. 373-380
Author(s):  
Stewart McLachlin ◽  
Jason Leung ◽  
Vignesh Sivan ◽  
Pierre-Olivier Quirion ◽  
Phoenix Wilkie ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Tracts ◽  
Spatial Correspondence

Individual differences in white and grey matter structure associated with verbal habits of thought

2019 ◽  
Author(s):  
Justin C. Hayes ◽  
Katherine L Alfred ◽  
Rachel Pizzie ◽  
Joshua S. Cetron ◽  
David J. M. Kraemer
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Cognitive Processing ◽  
Grey Matter ◽  
Structural Changes ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Self Report ◽  
White Matter Tracts

Modality specific encoding habits account for a significant portion of individual differences reflected in functional activation during cognitive processing. Yet, little is known about how these habits of thought influence long-term structural changes in the brain. Traditionally, habits of thought have been assessed using self-report questionnaires such as the visualizer-verbalizer questionnaire. Here, rather than relying on subjective reports, we measured habits of thought using a novel behavioral task assessing attentional biases toward picture and word stimuli. Hypothesizing that verbal habits of thought are reflected in the structural integrity of white matter tracts and cortical regions of interest, we used diffusion tensor imaging and volumetric analyses to assess this prediction. Using a whole-brain approach, we show that word bias is associated with increased volume in several bilateral language regions, in both white and grey matter parcels. Additionally, connectivity within white matter tracts within an a priori speech production network increased as a function of word bias. These results demonstrate long-term structural and morphological differences associated with verbal habits of thought.

scholarly journals White matter in prolonged glucocorticoid response to psychological stress in schizophrenia

2021 ◽  
Author(s):  
Eric L. Goldwaser ◽  
Joshua Chiappelli ◽  
Mark D. Kvarta ◽  
Xiaoming Du ◽  
Zachary B. Millman ◽  
...  
Keyword(s):  
White Matter ◽  
Psychological Stress ◽  
Stress Responses ◽  
Diffusion Tensor ◽  
Brain Network ◽  
White Matter Tracts ◽  
Cortisol Reactivity ◽  
Cortisol Responses ◽  
Psychological Stressor ◽  
Post Stress

AbstractStress is implicated in psychosis etiology and exacerbation, but pathogenesis toward brain network alterations in schizophrenia remain unclear. White matter connects limbic and prefrontal regions responsible for stress response regulation, and white matter tissues are also vulnerable to glucocorticoid aberrancies. Using a novel psychological stressor task, we studied cortisol stress responses over time and white matter microstructural deficits in schizophrenia spectrum disorder (SSD). Cortisol was measured at baseline, 0-, 20-, and 40-min after distress induction by a psychological stressor task in 121 SSD patients and 117 healthy controls (HC). White matter microstructural integrity was measured by 64-direction diffusion tensor imaging. Fractional anisotropy (FA) in white matter tracts were related to cortisol responses and then compared to general patterns of white matter tract deficits in SSD identified by mega-analysis. Differences between 40-min post-stress and baseline, but not acute reactivity post-stress, was significantly elevated in SSD vs HC, time × diagnosis interaction F2.3,499.9 = 4.1, p = 0.013. All SSD white matter tracts were negatively associated with prolonged cortisol reactivity but all tracts were positively associated with prolonged cortisol reactivity in HC. Individual tracts most strongly associated with prolonged cortisol reactivity were also most impacted in schizophrenia in general as established by the largest schizophrenia white matter study (r = −0.56, p = 0.006). Challenged with psychological stress, SSD and HC mount similar cortisol responses, and impairments arise in the resolution timeframe. Prolonged cortisol elevations are associated with the white matter deficits in SSD, in a pattern previously associated with schizophrenia in general.

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