scholarly journals Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells

Data in Brief ◽  
2016 ◽  
Vol 6 ◽  
pp. 1023-1027 ◽  
Author(s):  
Vanessa Lopes-Rodrigues ◽  
Alessio Di Luca ◽  
Diana Sousa ◽  
Hugo Seca ◽  
Paula Meleady ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Multidrug Resistant ◽  
Tumour Cells

scholarly journals Bacterial Membrane Vesicles in Pneumonia: From Mediators of Virulence to Innovative Vaccine Candidates

2021 ◽  
Vol 22 (8) ◽  
pp. 3858
Author(s):  
Felix Behrens ◽  
Teresa C. Funk-Hilsdorf ◽  
Wolfgang M. Kuebler ◽  
Szandor Simmons
Keyword(s):  
Extracellular Vesicles ◽  
Inflammatory Responses ◽  
Significant Proportion ◽  
Treatment Strategies ◽  
Membrane Vesicles ◽  
Multidrug Resistant ◽  
Biochemical Properties ◽  
Outer Membrane Vesicles ◽  
Vaccine Candidates ◽  
Treatment Regimens

Pneumonia due to respiratory infection with most prominently bacteria, but also viruses, fungi, or parasites is the leading cause of death worldwide among all infectious disease in both adults and infants. The introduction of modern antibiotic treatment regimens and vaccine strategies has helped to lower the burden of bacterial pneumonia, yet due to the unavailability or refusal of vaccines and antimicrobials in parts of the global population, the rise of multidrug resistant pathogens, and high fatality rates even in patients treated with appropriate antibiotics pneumonia remains a global threat. As such, a better understanding of pathogen virulence on the one, and the development of innovative vaccine strategies on the other hand are once again in dire need in the perennial fight of men against microbes. Recent data show that the secretome of bacteria consists not only of soluble mediators of virulence but also to a significant proportion of extracellular vesicles—lipid bilayer-delimited particles that form integral mediators of intercellular communication. Extracellular vesicles are released from cells of all kinds of organisms, including both Gram-negative and Gram-positive bacteria in which case they are commonly termed outer membrane vesicles (OMVs) and membrane vesicles (MVs), respectively. (O)MVs can trigger inflammatory responses to specific pathogens including S. pneumonia, P. aeruginosa, and L. pneumophila and as such, mediate bacterial virulence in pneumonia by challenging the host respiratory epithelium and cellular and humoral immunity. In parallel, however, (O)MVs have recently emerged as auspicious vaccine candidates due to their natural antigenicity and favorable biochemical properties. First studies highlight the efficacy of such vaccines in animal models exposed to (O)MVs from B. pertussis, S. pneumoniae, A. baumannii, and K. pneumoniae. An advanced and balanced recognition of both the detrimental effects of (O)MVs and their immunogenic potential could pave the way to novel treatment strategies in pneumonia and effective preventive approaches.

scholarly journals Selective modulation of vinblastine sensitivity by 1,9-dideoxyforskolin and related diterpenes in multidrug resistant tumour cells

1993 ◽  
Vol 67 (3) ◽  
pp. 471-479 ◽  
Author(s):  
DR Shalinsky ◽  
DD Heath ◽  
AP Jekunen ◽  
JE Alcaraz ◽  
SB Howell
Keyword(s):  
Multidrug Resistant ◽  
Tumour Cells ◽  
Selective Modulation

scholarly journals Circulating biomarkers in patients with glioblastoma

2019 ◽  
Vol 122 (3) ◽  
pp. 295-305 ◽  
Author(s):  
Juliana Müller Bark ◽  
Arutha Kulasinghe ◽  
Benjamin Chua ◽  
Bryan W. Day ◽  
Chamindie Punyadeera
Keyword(s):  
Extracellular Vesicles ◽  
Tumour Progression ◽  
Imaging Techniques ◽  
Therapy Response ◽  
Invasive Procedure ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Circulating Biomarkers ◽  
Liquid Biopsies ◽  
The Central Nervous System

Abstract Gliomas are the most common tumours of the central nervous system and the most aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival remains low. GBM diagnosis typically relies on imaging techniques and postoperative pathological diagnosis; however, both procedures have their inherent limitations. Imaging modalities cannot differentiate tumour progression from treatment-related changes that mimic progression, known as pseudoprogression, which might lead to misinterpretation of therapy response and delay clinical interventions. In addition to imaging limitations, tissue biopsies are invasive and most of the time cannot be performed over the course of treatment to evaluate ‘real-time’ tumour dynamics. In an attempt to address these limitations, liquid biopsies have been proposed in the field. Blood sampling is a minimally invasive procedure for a patient to endure and could provide tumoural information to guide therapy. Tumours shed tumoural content, such as circulating tumour cells, cell-free nucleic acids, proteins and extracellular vesicles, into the circulation, and these biomarkers are reported to cross the blood–brain barrier. The use of liquid biopsies is emerging in the field of GBM. In this review, we aim to summarise the current literature on circulating biomarkers, namely circulating tumour cells, circulating tumour DNA and extracellular vesicles as potential non-invasively sampled biomarkers to manage the treatment of patients with GBM.

Saturable Function of P-Glycoprotein as a Drug-efflux Pump in Multidrug-resistant Tumour Cells

1996 ◽  
Vol 48 (5) ◽  
pp. 522-525 ◽  
Author(s):  
KEN-ICHI MIYAMOTO ◽  
KEIKO KOGA-TAKEDA ◽  
KENJIRO KOGA ◽  
TAEYUKI OHSHIMA ◽  
MASAAKI NOMURA
Keyword(s):  
Efflux Pump ◽  
Multidrug Resistant ◽  
Tumour Cells ◽  
Drug Efflux ◽  
P Glycoprotein ◽  
Drug Efflux Pump

scholarly journals Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells

1993 ◽  
Vol 68 (5) ◽  
pp. 939-946 ◽  
Author(s):  
CHM Versantvoort ◽  
GJ Schuurhuis ◽  
HM Pinedo ◽  
CA Eekman ◽  
CM Kuiper ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Tumour Cells ◽  
Drug Accumulation ◽  
P Glycoprotein

scholarly journals Year of Expanding into Circulating Biomarkers

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Shidong Jia ◽  
Winston Patrick Kuo
Keyword(s):  
Extracellular Vesicles ◽  
Tumour Cells ◽  
Circulating Dna ◽  
Circulating Tumour Cells ◽  
Protein Markers ◽  
Circulating Biomarkers ◽  
High Quality ◽  
Private Funding ◽  
Strategic Approach ◽  
Free Circulating Dna

This editorial article summarizes the achievements and current challenges for the Journal of Circulating Biomarkers (JCB) regarding a more strategic approach to branding and attracting a high quality variety of articles. More emphasis is placed on fostering engagement with academic and industry sources operating at the cutting-edge of translational technologies applied to the field of circulating biomarkers (interface between extracellular vesicles including exosomes and microvesicles, circulating tumour cells, cell-free circulating DNA and circulating protein markers) and with those in the investment arena seeking and providing private funding for this area of research.

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