The bidirectional association between body weight and mobility disability: A population-based cohort

2016 ◽  
Vol 9 (4) ◽  
pp. 632-637 ◽  
Author(s):  
Jeroen S. de Munter ◽  
Per Tynelius ◽  
Gerd Ahlström ◽  
Finn Rasmussen
Keyword(s):  
Body Weight ◽  
Population Based ◽  
Mobility Disability ◽  
Bidirectional Association

scholarly journals Melanoma is associated with an increased risk of bullous pemphigoid: a large population-based longitudinal study

2021 ◽  
Author(s):  
Khalaf Kridin ◽  
Jennifer E. Hundt ◽  
Ralf J. Ludwig ◽  
Kyle T. Amber ◽  
Dana Tzur Bitan ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Statistical Significance ◽  
Large Population ◽  
Underlying Mechanism ◽  
Population Based ◽  
Control Subjects ◽  
Increased Risk ◽  
Bidirectional Association ◽  
History Of ◽  
Incident Cases

AbstractThe association between bullous pemphigoid (BP) and melanoma is yet to be investigated. We aimed to assess assess the bidirectional association between BP and melanoma and to delineate the epidemiological features of patients with both diagnoses. A population-based cohort study was performed comparing BP patients (n = 3924) with age-, sex- and ethnicity-matched control subjects (n = 19,280) with regard to incident cases of melanoma. A case–control design was additionally adopted to estimate the risk of BP in individuals with a preexisting diagnosis of melanoma. The prevalence of preexisting melanoma was higher in patients with BP than in control subjects (1.5% vs. 1.0%, respectively; P = 0.004). A history of melanoma confers a 50% increase in the risk of subsequent BP (OR 1.53; 95% CI 1.14–2.06). This risk was higher among males (OR 1.66; 95% CI 1.09–2.54) and individuals older than 80 years (OR 1.63; 95% CI 1.11–2.38), and persisted after adjustment for multiple putative confounders including PD-1/PDL-1 antagonists (adjusted OR 1.53; 95% CI 1.14–2.06). Conversely, the risk of melanoma among patients with BP was slightly elevated, but did not reach the level of statistical significance (adjusted HR 1.13; 95% CI 0.73–1.74). Patients with a dual diagnosis of BP and melanoma were older at the onset of BP and had lower body mass index. A history of melanoma is associated with a 50% increase in the incidence of subsequent BP. Physicians managing patients with both conditions should be aware of this association. Further research is warranted to reveal the underlying mechanism of these findings.

The relationship between body weight and drug costs: An Italian population-based study

2006 ◽  
Vol 28 (9) ◽  
pp. 1472-1481 ◽  
Author(s):  
Ezio Degli Esposti ◽  
Alessandra Sturani ◽  
Giorgia Valpiani ◽  
Mirko Di Martino ◽  
Francesco Ziccardi ◽  
...  
Keyword(s):  
Body Weight ◽  
Population Based ◽  
Drug Costs ◽  
Italian Population ◽  
Population Based Study ◽  
The Relationship

scholarly journals Creatinine-to-body weight ratio is a predictor of incident diabetes: a population-based retrospective cohort study

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Jiacheng He
Keyword(s):  
Body Weight ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Proportional Hazards ◽  
Weight Ratio ◽  
Threshold Effect ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Incident Type

Abstract Purpose Creatinine to body weight (Cre/BW) ratio is considered the independent risk factor for incident type 2 diabetes mellitus (T2DM), but research on this relationship is limited. The relationship between the Cre/BW ratio and T2DM among Chinse individuals is still ambiguous. This study aimed to evaluate the correlation between the Cre/BW ratio and the risk of T2DM in the Chinese population. Methods This is a retrospective cohort study from a prospectively collected database. We included a total of 200,658 adults free of T2DM at baseline. The risk of incident T2DM according to Cre/BW ratio was estimated using multivariable Cox proportional hazards models, and a two-piece wise linear regression model was developed to find out the threshold effect. Results With a median follow-up of 3.13 ± 0.94 years, a total of 4001 (1.99%) participants developed T2DM. Overall, there was an L-shaped relation of Cre/BW ratio with the risk of incident T2DM (P for non-linearity < 0.001). When the Cre/BW ratio (× 100) was less than 0.86, the risk of T2DM decreased significantly as the Cre/BW ratio increased [0.01 (0.00, 0.10), P < 0.001]. When the Cre/BW ratio (× 100) was between 0.86 and 1.36, the reduction in the risk of developing T2DM was not as significant as before [0.22 (0.12, 0.38), P < 0.001]. In contrast, when the Cre/BW ratio (× 100) was greater than 1.36, the reduction in T2DM incidence became significantly flatter than before [0.73 (0.29,1.8), P = 0.49]. Conclusion There was an L-shaped relation of Cre/BW ratio with incidence of T2DM in general Chinese adults. A negative curvilinear association between Cre/BW ratio and incident T2DM was present, with a saturation effect predicted at 0.86 and 1.36 of Cre/BW ratio (× 100).

Sex-Specific Association Between Antidepressant Use and Body Weight in a Population-Based Study in Older Adults

2015 ◽  
Vol 76 (06) ◽  
pp. e745-e751 ◽  
Author(s):  
Raymond Noordam ◽  
Nikkie Aarts ◽  
Henning Tiemeier ◽  
Albert Hofman ◽  
Bruno H. Stricker ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Weight ◽  
Population Based ◽  
Population Based Study ◽  
Antidepressant Use ◽  
Specific Association

Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study

2020 ◽  
Vol 91 (8) ◽  
pp. 867-875 ◽  
Author(s):  
Mark R Janse van Mantgem ◽  
Ruben P A van Eijk ◽  
Hannelore K van der Burgh ◽  
Harold H G Tan ◽  
Henk-Jan Westeneng ◽  
...  
Keyword(s):  
Weight Loss ◽  
Amyotrophic Lateral Sclerosis ◽  
Body Weight ◽  
Prognostic Value ◽  
Population Based ◽  
Data Set ◽  
Population Based Study ◽  
Risk Of Death ◽  
Lateral Sclerosis

ObjectiveTo determine the prevalence and prognostic value of weight loss (WL) prior to diagnosis in patients with amyotrophic lateral sclerosis (ALS).MethodsWe enrolled patients diagnosed with ALS between 2010 and 2018 in a population-based setting. At diagnosis, detailed information was obtained regarding the patient’s disease characteristics, anthropological changes, ALS-related genotypes and cognitive functioning. Complete survival data were obtained. Cox proportional hazard models were used to assess the association between WL and the risk of death during follow-up.ResultsThe data set comprised 2420 patients of whom 67.5% reported WL at diagnosis. WL occurred in 71.8% of the bulbar-onset and in 64.2% of the spinal-onset patients; the mean loss of body weight was 6.9% (95% CI 6.8 to 6.9) and 5.5% (95% CI 5.5 to 5.6), respectively (p<0.001). WL occurred in 35.1% of the patients without any symptom of dysphagia. WL is a strong independent predictor of survival, with a dose response relationship between the amount of WL and the risk of death: the risk of death during follow-up increased by 23% for every 10% increase in WL relative to body weight (HR 1.23, 95% CI 1.13 to 1.51, p<0.001).ConclusionsThis population-based study shows that two-thirds of the patients with ALS have WL at diagnosis, which also occurs independent of dysphagia, and is related to survival. Our results suggest that WL is a multifactorial process that may differ from patient to patient. Gaining further insight in its underlying factors could prove essential for future therapeutic measures.

scholarly journals Trends in excess weight and thinness among Spanish schoolchildren in the period 1992–2004: the Cuenca study

2009 ◽  
Vol 12 (7) ◽  
pp. 1015-1018 ◽  
Author(s):  
Vicente Martínez-Vizcaíno ◽  
Mairena Sánchez López ◽  
Pablo Moya Martínez ◽  
Montserrat Solera Martinez ◽  
Blanca Notario Pacheco ◽  
...  
Keyword(s):  
Body Weight ◽  
Childhood Obesity ◽  
Developed Countries ◽  
Population Based ◽  
Cross Sectional ◽  
Old Spanish ◽  
Trained Personnel ◽  
Dual Burden ◽  
Cross Sectional Studies ◽  
Frequent Problem

AbstractBackgroundIn developed countries, there is abundant information on the epidemic of childhood obesity, but only a few studies on trends in the dual burden of body weight (overweight and thinness).ObjectiveTo examine trends in overweight and thinness among 9–10-year-old Spanish children in the last decade.MethodsData were taken from cross-sectional studies on schoolchildren in Cuenca (Spain), conducted in 1992, 1996, 1998 and 2004 with similar methods. Weight and height were measured by trained personnel with standardized procedures. Overweight (including obesity) and thinness were defined according with the International Obesity Taskforce BMI cut-offs.ResultsThe overall prevalence of overweight increased from 24·4 % in 1992 to 30·9 % in 2004 (P = 0·07), rising from 21·2 % in 1992 to 32·0 % in 2004 (P = 0·03) among boys and from 27·7 % to 29·8 % (P = 0·67) among girls. The overall prevalence of thinness was 2·7 % in 1992 and 9·2 % in 2004 (P < 0·001); in the same period, thinness prevalence rose from 1·9 % to 9·0 % (P = 0·10) among boys and from 3·7 % to 9·5 % (P < 0·01) among girls.ConclusionsThe dual burden of body weight has increased among children in Cuenca in the last decade. Population-based policies addressing childhood obesity, which is the most frequent problem, should not increase the risk of thinness.

scholarly journals Body Weight Variability Increases Dementia Risk Among Older Adults: A Nationwide Population-Based Cohort Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Eun Roh ◽  
Soon Young Hwang ◽  
Jung A. Kim ◽  
You-Bin Lee ◽  
So-hyeon Hong ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Weight ◽  
Cohort Study ◽  
Population Based ◽  
Dementia Risk
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