Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease

2021 ◽  
Vol 56 (9) ◽  
pp. 1238-1252.e5
Author(s):  
Bo Zhang ◽  
M. Yvonne Kim ◽  
GiNell Elliot ◽  
Yan Zhou ◽  
Guangfeng Zhao ◽  
...  
Keyword(s):  
Placental Disease

scholarly journals Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction

2021 ◽  
Vol 22 (14) ◽  
pp. 7467
Author(s):  
Ciara N. Murphy ◽  
Susan P. Walker ◽  
Teresa M. MacDonald ◽  
Emerson Keenan ◽  
Natalie J. Hannan ◽  
...  
Keyword(s):  
Stem Cells ◽  
First Trimester ◽  
Placental Insufficiency ◽  
Human Trophoblast ◽  
Trophoblast Stem Cells ◽  
Placental Dysfunction ◽  
Foetal Growth Restriction ◽  
Term Delivery ◽  
Placental Disease ◽  
Prospective Cohorts

Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functionally related placental protease inhibitor. This study aimed to characterise SPINT2 expression in placental insufficiency. Circulating SPINT2 was assessed in three prospective cohorts, collected at the following: (1) term delivery (n = 227), (2) 36 weeks (n = 364), and (3) 24–34 weeks’ (n = 294) gestation. SPINT2 was also measured in the plasma and placentas of women with established placental disease at preterm (<34 weeks) delivery. Using first-trimester human trophoblast stem cells, SPINT2 expression was assessed in hypoxia/normoxia (1% vs. 8% O2), and following inflammatory cytokine treatment (TNFa, IL-6). Placental SPINT2 mRNA was measured in a rat model of late-gestational foetal growth restriction. At 36 weeks, circulating SPINT2 was elevated in patients who later developed preeclampsia (p = 0.028; median = 2233 pg/mL vs. controls, median = 1644 pg/mL), or delivered a small-for-gestational-age infant (p = 0.002; median = 2109 pg/mL vs. controls, median = 1614 pg/mL). SPINT2 was elevated in the placentas of patients who required delivery for preterm preeclampsia (p = 0.025). Though inflammatory cytokines had no effect, hypoxia increased SPINT2 in cytotrophoblast stem cells, and its expression was elevated in the placental labyrinth of growth-restricted rats. These findings suggest elevated SPINT2 is associated with placental insufficiency.

Doppler velocimetry and placental disease

1989 ◽  
Vol 161 (2) ◽  
pp. 388-393 ◽  
Author(s):  
Luis A. Bracero ◽  
Debra Beneck ◽  
Nancy Kirshenbaum ◽  
Marianne Peiffer ◽  
Patricia Stalter ◽  
...  
Keyword(s):  
Doppler Velocimetry ◽  
Placental Disease

scholarly journals 266: Invasive placental disease: the impact of a multi-disciplinary approach to management

2016 ◽  
Vol 214 (1) ◽  
pp. S156
Author(s):  
John C. Smulian ◽  
Ana-Liza Pascual ◽  
Helai Hesham ◽  
Emma Qureshey ◽  
M Bijoy Thomas ◽  
...  
Keyword(s):  
Placental Disease ◽  
The Impact

scholarly journals Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term

2002 ◽  
pp. 785-793 ◽  
Author(s):  
NA Bersinger ◽  
N Groome ◽  
S Muttukrishna
Keyword(s):  
Pregnant Women ◽  
Protein A ◽  
Placental Tissue ◽  
Serum Levels ◽  
Activin A ◽  
Placental Lactogen ◽  
Compensatory Mechanism ◽  
Protein Markers ◽  
Inhibin A ◽  
Placental Disease

OBJECTIVE: Pre-eclampsia is a placental disease of unknown cause. Maternal circulating concentrations of a number of protein markers are altered (mainly increased) in pre-eclampsia in comparison with controls of matched gestational age. Inhibin A and activin A were found to be elevated even before the onset of the disease. The aim of this study was to compare the levels of inhibin A, activin A: follistatin ratio, leptin, pregnancy-associated plasma protein-A (PAPP-A), human placental lactogen (HPL), placenta growth factor (PLGF) and pregnancy-specific beta1-glycoprotein (SP1) in placental extracts of normal pregnant women and pre-eclampsia patients at term. METHODS: Placental tissue from normal pregnancies (n=14) and patients with pre-eclampsia (n=13) were collected at term (> or =37 weeks of gestation) and stored at -80 degrees C. The frozen tissue pieces were homogenised and the above-mentioned proteins were measured by specific enzyme-linked immunosorbent assays. RESULTS: Placental contents of inhibin A and PAPP-A were significantly higher (P<0.05) in pre-eclampsia placental extracts compared with the controls. Activin A:follistatin ratio was higher (23) in pre-eclampsia extracts than in the controls (15). Leptin, PLGF, SP1 and HPL levels were not altered in the term pre-eclampsia placenta. Inhibin A and PAPP-A contents were increased in the placental extracts of pre-eclampsia patients. CONCLUSION: Our data suggest that the placenta, possibly by a compensatory mechanism, is at least in part responsible for the altered serum levels observed in pre-eclampsia.

Hereditary thrombophilia and recurrence of ischemic placental disease

2010 ◽  
Vol 202 (1) ◽  
pp. 54.e1-54.e5 ◽  
Author(s):  
Eric Verspyck ◽  
Jeanne-Yvonne Borg ◽  
Horace Roman ◽  
Bernard Thobois ◽  
Patrick Pia ◽  
...  
Keyword(s):  
Hereditary Thrombophilia ◽  
Placental Disease

scholarly journals Risk of ischemic placental disease in fresh and frozen embryo transfer cycles

2019 ◽  
Vol 111 (4) ◽  
pp. 714-721 ◽  
Author(s):  
Katherine M. Johnson ◽  
Michele R. Hacker ◽  
Nina Resetkova ◽  
Barbara O'Brien ◽  
Anna M. Modest
Keyword(s):  
Embryo Transfer ◽  
Frozen Embryo Transfer ◽  
Placental Disease

First-trimester maternal serum alpha fetoprotein is associated with ischemic placental disease

2020 ◽  
Vol 222 (5) ◽  
pp. 499.e1-499.e6
Author(s):  
Cheryl Dinglas ◽  
Nur Afsar ◽  
Elizabeth Cochrane ◽  
Jay Davis ◽  
Sara Kim ◽  
...  
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Placental Disease ◽  
Serum Alpha Fetoprotein
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