scholarly journals Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells

2019 ◽  
Vol 49 (3) ◽  
pp. 444-460.e9 ◽  
Author(s):  
Ashwathi S. Mohan ◽  
Kevin M. Dean ◽  
Tadamoto Isogai ◽  
Stacy Y. Kasitinon ◽  
Vasanth S. Murali ◽  
...  
Keyword(s):  
Network Formation ◽  
Melanoma Cells ◽  
Actin Network

scholarly journals miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Benoît Chevalier ◽  
Anna Adamiok ◽  
Olivier Mercey ◽  
Diego R. Revinski ◽  
Laure-Emmanuelle Zaragosi ◽  
...  
Keyword(s):  
Network Formation ◽  
Small Gtpase ◽  
Actin Network

F-actin network formation in tethers and in pseudopods stimulated by chemoattractant

1996 ◽  
Vol 35 (4) ◽  
pp. 331-344 ◽  
Author(s):  
Doncho V. Zhelev ◽  
Abdullatif M. Alteraifi ◽  
Robert M. Hochmuth
Keyword(s):  
Network Formation ◽  
Actin Network

Effects of Angiogenesis Inhibitors on Vascular Network Formation by Human Endothelial and Melanoma Cells

2004 ◽  
Vol 96 (19) ◽  
pp. 1473-1477 ◽  
Author(s):  
D. W. J. van der Schaft ◽  
R. E. B. Seftor ◽  
E. A. Seftor ◽  
A. R. Hess ◽  
L. M. Gruman ◽  
...  
Keyword(s):  
Network Formation ◽  
Angiogenesis Inhibitors ◽  
Melanoma Cells ◽  
Vascular Network

Actin Network Formation by Unidirectional Polycation Diffusion

Langmuir ◽  
2007 ◽  
Vol 23 (11) ◽  
pp. 6257-6262 ◽  
Author(s):  
Hyuck Joon Kwon ◽  
Akira Kakugo ◽  
Takehiro Ura ◽  
Takaharu Okajima ◽  
Yoshimi Tanaka ◽  
...  
Keyword(s):  
Network Formation ◽  
Actin Network

scholarly journals Actin network architecture and elasticity in lamellipodia of melanoma cells

2007 ◽  
Vol 9 (11) ◽  
pp. 420-420 ◽  
Author(s):  
Frank Fleischer ◽  
Revathi Ananthakrishnan ◽  
Stefanie Eckel ◽  
Hendrik Schmidt ◽  
Josef Käs ◽  
...  
Keyword(s):  
Network Architecture ◽  
Melanoma Cells ◽  
Actin Network

scholarly journals Mechanisms for Dendritic Actin Network Formation, Distributed Turnover, and Structural Remodeling

2019 ◽  
Vol 116 (3) ◽  
pp. 456a
Author(s):  
Danielle Holz ◽  
Aaron Hall ◽  
Dimitrios Vavylonis
Keyword(s):  
Network Formation ◽  
Actin Network ◽  
Structural Remodeling

scholarly journals Hydraulic resistance induces cell phenotypic transition in confinement

2021 ◽  
Vol 7 (17) ◽  
pp. eabg4934
Author(s):  
Runchen Zhao ◽  
Siqi Cui ◽  
Zhuoxu Ge ◽  
Yuqi Zhang ◽  
Kaustav Bera ◽  
...  
Keyword(s):  
Hydraulic Resistance ◽  
Focal Adhesion ◽  
Actin Filaments ◽  
Fluorescence Recovery After Photobleaching ◽  
Network Formation ◽  
Calcium Oscillations ◽  
Cell Phenotype ◽  
Actin Network ◽  
Mesenchymal Transition ◽  
Phenotypic Transition

Cells penetrating into confinement undergo mesenchymal-to-amoeboid transition. The topographical features of the microenvironment expose cells to different hydraulic resistance levels. How cells respond to hydraulic resistance is unknown. We show that the cell phenotype shifts from amoeboid to mesenchymal upon increasing resistance. By combining automated morphological tracking and wavelet analysis along with fluorescence recovery after photobleaching (FRAP), we found an oscillatory phenotypic transition that cycles from blebbing to short, medium, and long actin network formation, and back to blebbing. Elevated hydraulic resistance promotes focal adhesion maturation and long actin filaments, thereby reducing the period required for amoeboid-to-mesenchymal transition. The period becomes independent of resistance upon blocking the mechanosensor TRPM7. Mathematical modeling links intracellular calcium oscillations with actomyosin turnover and force generation and recapitulates experimental data. We identify hydraulic resistance as a critical physical cue controlling cell phenotype and present an approach for connecting fluorescent signal fluctuations to morphological oscillations.

Sign in / Sign up

Export Citation Format

Share Document