scholarly journals The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish

2010 ◽  
Vol 19 (5) ◽  
pp. 740-752 ◽  
Author(s):  
Marion Ségalen ◽  
Christopher A. Johnston ◽  
Charlotte A. Martin ◽  
Julien G. Dumortier ◽  
Kenneth E. Prehoda ◽  
...  
eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Yuwei Li ◽  
Ang Li ◽  
Jason Junge ◽  
Marianne Bronner

Both oriented cell divisions and cell rearrangements are critical for proper embryogenesis and organogenesis. However, little is known about how these two cellular events are integrated. Here we examine the linkage between these processes in chick limb cartilage. By combining retroviral-based multicolor clonal analysis with live imaging, the results show that single chondrocyte precursors can generate both single-column and multi-column clones through oriented division followed by cell rearrangements. Focusing on single column formation, we show that this stereotypical tissue architecture is established by a pivot-like process between sister cells. After mediolateral cell division, N-cadherin is enriched in the post-cleavage furrow; then one cell pivots around the other, resulting in stacking into a column. Perturbation analyses demonstrate that planar cell polarity signaling enables cells to pivot in the direction of limb elongation via this N-cadherin-mediated coupling. Our work provides new insights into the mechanisms generating appropriate tissue architecture of limb skeleton.


2008 ◽  
Vol 13 (9) ◽  
pp. 965-975 ◽  
Author(s):  
Yosuke Funato ◽  
Tatsuo Michiue ◽  
Takeshi Terabayashi ◽  
Akira Yukita ◽  
Hiroki Danno ◽  
...  

2019 ◽  
Vol 138 (4) ◽  
pp. 363-374 ◽  
Author(s):  
Marie Beaumont ◽  
Linda Akloul ◽  
Wilfrid Carré ◽  
Chloé Quélin ◽  
Hubert Journel ◽  
...  

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